Abstract:
OBJECTIVE:Guillain-Barré syndrome (GBS) is an acute postinfectious immune-mediated polyneuropathy. Although preceding respiratory tract infections with Mycoplasma pneumoniae have been reported in some cases, the role of M. pneumoniae in the pathogenesis of GBS remains unclear. We here cultured, for the first time, M. pneumoniae from a GBS patient with antibodies against galactocerebroside (GalC), which cross-reacted with the isolate. This case prompted us to unravel the role of M. pneumoniae in GBS in a case-control study. METHODS:We included 189 adults and 24 children with GBS and compared them to control cohorts for analysis of serum antibodies against M. pneumoniae (n = 479) and GalC (n = 198). RESULTS:Anti-M. pneumoniae immunoglobulin (Ig) M antibodies were detected in GBS patients and healthy controls in 3% and 0% of adults (p = 0.16) and 21% and 7% of children (p = 0.03), respectively. Anti-GalC antibodies (IgM and/or IgG) were found in 4% of adults and 25% of children with GBS (p = 0.001). Anti-GalC-positive patients showed more-frequent preceding respiratory symptoms, cranial nerve involvement, and a better outcome. Anti-GalC antibodies correlated with anti-M. pneumoniae antibodies (p < 0.001) and cross-reacted with different M. pneumoniae strains. Anti-GalC IgM antibodies were not only found in GBS patients with M. pneumoniae infection, but also in patients without neurological disease (8% vs 9%; p = 0.87), whereas anti-GalC IgG was exclusively found in patients with GBS (9% vs 0%; p = 0.006). INTERPRETATION:M. pneumoniae infection is associated with GBS, more frequently in children than adults, and elicits anti-GalC antibodies, of which specifically anti-GalC IgG may contribute to the pathogenesis of GBS. Ann Neurol 2016;80:566-580.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Meyer Sauteur PM,Huizinga R,Tio-Gillen AP,Roodbol J,Hoogenboezem T,Jacobs E,van Rijn M,van der Eijk AA,Vink C,de Wit MC,van Rossum AM,Jacobs BCdoi
10.1002/ana.24755subject
Has Abstractpub_date
2016-10-01 00:00:00pages
566-80issue
4eissn
0364-5134issn
1531-8249journal_volume
80pub_type
杂志文章abstract::Human immunodeficiency viruses from the brain can be distinguished from peripheral blood isolates by their ability to infect established human cell lines and their sensitivity to serum neutralization. Isolates from the brain and lymph nodes obtained from the same person displayed similar host range tropism and suscept...
journal_title:Annals of neurology
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doi:10.1002/ana.410230716
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doi:10.1002/ana.24946
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journal_title:Annals of neurology
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doi:10.1002/ana.410380204
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doi:10.1002/ana.410360704
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abstract:OBJECTIVES:African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non-Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social and environmental factors may increase the risk of AD dementia. This paper (1) assesses neuroimagin...
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journal_title:Annals of neurology
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doi:10.1002/ana.410390318
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abstract::A novel mitochondrial DNA transfer RNA mutation at position 5549 was identified in a patient with dementia, chorea, cerebellar ataxia, deafness, and peripheral neuropathy in the absence of clinical myopathy. Muscle biopsy specimens showed ragged red and cytochrome oxidase-negative fibers, and reduced complex I activit...
journal_title:Annals of neurology
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doi:10.1002/ana.410370317
更新日期:1995-03-01 00:00:00
abstract::Eighty-three patients with epidural spinal cord compression, from metastatic cancer were treated with high-dose adrenocorticosteroids and a new radiation fractionation protocol. Only those patients were included who had complete or almost complete block on myelography and who had not received prior radiation therapy t...
journal_title:Annals of neurology
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doi:10.1002/ana.410080404
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journal_title:Annals of neurology
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doi:10.1002/ana.410250511
更新日期:1989-05-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410100512
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更新日期:2020-01-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410400109
更新日期:1996-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410180306
更新日期:1985-09-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410400310
更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410160102
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pub_type: 杂志文章
doi:10.1002/ana.410260603
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journal_title:Annals of neurology
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doi:10.1002/ana.410320502
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journal_title:Annals of neurology
pub_type: 杂志文章,评审
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更新日期:2009-10-01 00:00:00
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doi:10.1002/ana.21339
更新日期:2008-04-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410200209
更新日期:1986-08-01 00:00:00
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更新日期:2021-01-06 00:00:00