Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.


:Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.


Ann Neurol


Annals of neurology


Askanas V,Alvarez RB,Mirabella M,Engel WK




Has Abstract


1996-03-01 00:00:00












  • Quantitative cerebrospinal fluid cytology in patients receiving intracavitary chemotherapy.

    abstract::Cytological evaluation of cerebrospinal fluid (CSF) is an important means of following response to intracavitary chemotherapy for leptomeningeal malignancy. We studied the feasibility of quantitative cytological evaluation by retrospective analysis of serial CSF specimens from 7 patients receiving phase I intracavitar...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Russack V,Kim S,Chamberlain MC

    更新日期:1993-07-01 00:00:00

  • Human leukocyte antigen studies in multiple sclerosis.

    abstract::Multiple sclerosis (MS) has been associated with HLA-DR2 for more than 20 years, and a large number of studies have addressed the relation between MS and the HLA class II genes, which are our major immune-response genes. This has produced a complex and confusing picture that is difficult to interpret. With the advent ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Hillert J

    更新日期:1994-01-01 00:00:00

  • Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease.

    abstract::To determine whether the association of the very low density lipoprotein receptor (VLDL-R) gene with Alzheimer's disease (AD), which has recently been identified in Japanese AD patients, is commonly observed in AD patients of other ethnic backgrounds, we have investigated the allele frequency of the polymorphic CGG re...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Okuizumi K,Onodera O,Seki K,Tanaka H,Namba Y,Ikeda K,Saunders AM,Pericak-Vance MA,Roses AD,Tsuji S

    更新日期:1996-08-01 00:00:00

  • Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis.

    abstract:OBJECTIVE:Cortical spreading depolarizations (CSDs) are intense and ubiquitous depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs disrupt the blood-brain barrier (BBB), but the mechanisms are unknown. METHODS:A total of six CSDs were evoked over 1 hour by topical application of 30...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sadeghian H,Lacoste B,Qin T,Toussay X,Rosa R,Oka F,Chung DY,Takizawa T,Gu C,Ayata C

    更新日期:2018-09-01 00:00:00

  • Electrophysiology in Guillain-Barré syndrome.

    abstract::Clinical electrophysiological studies are important in the evaluation of patients with Guillain-Barré syndrome. Physiological evidence of demyelination occurs in almost all patients with Guillain-Barré syndrome, especially if serial studies are performed. Criteria for demyelination are proposed. Prognostic information...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Cornblath DR

    更新日期:1990-01-01 00:00:00

  • Mitochondrial dysfunction in Parkinson's disease.

    abstract::This review discusses the etiology and pathogenesis of Parkinson's disease (PD). Mitochondrial respiratory failure and oxidative stress appear to be two major contributors to nigral neuronal death in PD. Complex I deficiency has been reported by several groups and appears to be one of the basic abnormalities responsib...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Mizuno Y,Yoshino H,Ikebe S,Hattori N,Kobayashi T,Shimoda-Matsubayashi S,Matsumine H,Kondo T

    更新日期:1998-09-01 00:00:00

  • Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.

    abstract::We previously reported a marked increase of a 20,000 molecular weight (MW) protein, P20, in some neuronal fractions and whole cortical homogenates isolated from affected cortex in Alzheimer disease; P20 comigrated electrophoretically with an unidentified, major 20,000 MW protein present in human neurofilament (NF) fra...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Selkoe DJ,Brown BA,Salazar FJ,Marotta CA

    更新日期:1981-11-01 00:00:00

  • Genetic evidence for the involvement of tau in progressive supranuclear palsy.

    abstract::A dinucleotide repeat polymorphism in a tau intron was identified and used in a case-control study to analyze the genetic association of tau with several neurodegenerative diseases with tau pathology. Subjects with the homozygous tau AO alleles were excessively represented in the progressive supranuclear palsy (PSP) g...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Conrad C,Andreadis A,Trojanowski JQ,Dickson DW,Kang D,Chen X,Wiederholt W,Hansen L,Masliah E,Thal LJ,Katzman R,Xia Y,Saitoh T

    更新日期:1997-02-01 00:00:00

  • Primary central nervous system lymphoma in a patient treated with natalizumab.

    abstract::A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy. PCNSL is a disease of the elderly, with the majority of patients being diagnosed in the 7th to 8th decade of life. Immunodeficiency, ia...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Schweikert A,Kremer M,Ringel F,Liebig T,Duyster J,Stüve O,Hemmer B,Berthele A

    更新日期:2009-09-01 00:00:00

  • Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system.

    abstract::A 42-year-old homosexual man without evidence of immune deficiency developed cerebral granulomatous angiitis in association with the isolation of human T-lymphotropic virus type III (HTLV-III) from brain tissue and cerebrospinal fluid. This syndrome may be an additional neurological sequela of HTLV-III infection. ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Yankner BA,Skolnik PR,Shoukimas GM,Gabuzda DH,Sobel RA,Ho DD

    更新日期:1986-09-01 00:00:00

  • Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging.

    abstract:OBJECTIVE:Predicting hemorrhagic transformation (HT) is critical in the setting of recanalization therapy for acute stroke. Dedicated magnetic resonance imaging (MRI) sequences for detection of increased blood-brain barrier (BBB) permeability recently have been developed. We evaluated the ability of a novel MRI permeab...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bang OY,Buck BH,Saver JL,Alger JR,Yoon SR,Starkman S,Ovbiagele B,Kim D,Ali LK,Sanossian N,Jahan R,Duckwiler GR,Viñuela F,Salamon N,Villablanca JP,Liebeskind DS

    更新日期:2007-08-01 00:00:00

  • Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells.

    abstract::Spinal muscular atrophy (SMA) is a motor neuron disease caused by dysfunction of the survival motor neuron (SMN) gene. Human SMN gene is present in duplicated copies: SMN1 and SMN2. More than 95% of patients with SMA lack a functional SMN1 but retain at least one copy of SMN2. Unlike SMN1, SMN2 is primarily transcribe...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Grzeschik SM,Ganta M,Prior TW,Heavlin WD,Wang CH

    更新日期:2005-08-01 00:00:00

  • Elevated basic fibroblast growth factor in the serum of patients with Duchenne muscular dystrophy.

    abstract::The mechanism whereby dystrophin deficiency leads to excessive fibrosis and muscle degeneration is not known. The absence of dystrophin in skeletal muscle is associated with reduced plasma membrane stability as evidenced by elevated serum levels of the cytoplasmic enzyme creatine kinase. Basic fibroblast growth factor...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: D'Amore PA,Brown RH Jr,Ku PT,Hoffman EP,Watanabe H,Arahata K,Ishihara T,Folkman J

    更新日期:1994-03-01 00:00:00

  • A Trial of Sertraline or Cognitive Behavior Therapy for Depression in Epilepsy.

    abstract:OBJECTIVE:Limited evidence is available to guide treatment of depression for persons with epilepsy. We evaluated the comparative effectiveness of sertraline and cognitive behavior therapy (CBT) for depression, quality of life, seizures, and adverse treatment effects. METHODS:We randomly assigned 140 adult outpatients ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验


    authors: Gilliam FG,Black KJ,Carter J,Freedland KE,Sheline YI,Tsai WY,Lustman PJ

    更新日期:2019-10-01 00:00:00

  • Stroke prevention in nonvalvular atrial fibrillation: a review of prospective randomized trials.

    abstract::Patients with atrial fibrillation are at risk for cerebral embolism; however, the roles of chronic anticoagulation or antiplatelet therapy for stroke prevention in patients with nonvalvular atrial fibrillation have been controversial. Recently, the results of three large prospective randomized trials that examined the...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Albers GW,Sherman DG,Gress DR,Paulseth JE,Petersen P

    更新日期:1991-10-01 00:00:00

  • Reduced threshold for cortical spreading depression in female mice.

    abstract::The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C5...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Brennan KC,Romero Reyes M,López Valdés HE,Arnold AP,Charles AC

    更新日期:2007-06-01 00:00:00

  • Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids.

    abstract:OBJECTIVE:To clarify the histopathological alterations of microglia in the brains of patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS) caused by mutations of the gene encoding the colony stimulating factor-1 receptor (CSF-1R). METHODS:We examined 5 autopsied brains and 1 biopsy specimen from a...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Tada M,Konno T,Tada M,Tezuka T,Miura T,Mezaki N,Okazaki K,Arakawa M,Itoh K,Yamamoto T,Yokoo H,Yoshikura N,Ishihara K,Horie M,Takebayashi H,Toyoshima Y,Naito M,Onodera O,Nishizawa M,Takahashi H,Ikeuchi T,Kakita A

    更新日期:2016-10-01 00:00:00

  • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis.

    abstract::Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. This report describes abnormalities in excitatory amino acids in the central nervous system of 18 patients with amyotrophic lateral scleros...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Rothstein JD,Tsai G,Kuncl RW,Clawson L,Cornblath DR,Drachman DB,Pestronk A,Stauch BL,Coyle JT

    更新日期:1990-07-01 00:00:00

  • Early seizures after temporal lobectomy predict subsequent seizure recurrence.

    abstract::Patients are understandably anxious if seizures occur immediately after temporal lobectomy. Such "neighborhood" seizures are commonly regarded as irrelevant to seizure outcome and discounted in outcome measurement. We conducted an in-depth examination of early postoperative seizures (<28 days) and outcome. The risk of...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: McIntosh AM,Kalnins RM,Mitchell LA,Berkovic SF

    更新日期:2005-02-01 00:00:00

  • Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses.

    abstract:OBJECTIVE:Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Arngrim N,Hougaard A,Ahmadi K,Vestergaard MB,Schytz HW,Amin FM,Larsson HBW,Olesen J,Hoffmann MB,Ashina M

    更新日期:2017-12-01 00:00:00

  • Exercise intolerance due to a nonsense mutation in the mtDNA ND4 gene.

    abstract::We report the first molecular defect in an NADH-dehydrogenase gene presenting as isolated myopathy. The proband had lifelong exercise intolerance but no weakness. A muscle biopsy showed cytochrome c oxidase (COX)-positive ragged-red fibers (RRFs), and analysis of the mitochondrial enzymes revealed complex I deficiency...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Andreu AL,Tanji K,Bruno C,Hadjigeorgiou GM,Sue CM,Jay C,Ohnishi T,Shanske S,Bonilla E,DiMauro S

    更新日期:1999-06-01 00:00:00

  • McArdle's disease: biochemical and molecular genetic studies.

    abstract::We have analyzed muscle biopsy specimens from 48 patients with biochemically proven phosphorylase deficiency (McArdle's disease) by sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting, and immunotitration (enzyme-linked immunosorbent assay [ELISA]). Thirty-five of the 42 patients studi...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Servidei S,Shanske S,Zeviani M,Lebo R,Fletterick R,DiMauro S

    更新日期:1988-12-01 00:00:00

  • Recovery of hypermetria after a cerebellar stroke occurs as a multistage process.

    abstract::In a prospective study, we repeatedly recorded fast goal-directed wrist movements of 8 patients who had experienced an acute cerebellar hypermetria due to a stroke and who had subsequently recovered clinically. Movements and the associated agonist and antagonist electromyographic (EMG) activities were recorded before ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Manto M,Jacquy J,Hildebrand J,Godaux E

    更新日期:1995-09-01 00:00:00

  • Principles and pitfalls of nerve conduction studies.

    abstract::This report reviews the fundamental principles and the changing concepts of nerve stimulation techniques, and discusses the proper application of these techniques in the differential diagnosis of peripheral nerve disorders. Nerve conduction studies help delineate the extent and distribution of the neural lesion and di...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kimura J

    更新日期:1984-10-01 00:00:00

  • Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord.

    abstract::Mutations of copper,zinc-superoxide dismutase (cu,zn SOD) are found in patients with a familial form of amyotrophic lateral sclerosis. When expressed in transgenic mice, mutant human cu,zn SOD causes progressive loss of motor neurons with consequent paralysis and death. Expression profiling of gene expression in SOD1-...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Olsen MK,Roberds SL,Ellerbrock BR,Fleck TJ,McKinley DK,Gurney ME

    更新日期:2001-12-01 00:00:00

  • Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates.

    abstract::To examine the antiparkinsonian effects of blocking glycineB receptors, we designed a pilot study testing the potent and selective antagonist, PAMQX, in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. PAMQX had no intrinsic effects but markedly potentiated the antiparkinsonian action of levodopa. In a d...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Papa SM,Auberson YP,Greenamyre JT

    更新日期:2004-11-01 00:00:00

  • Aging, energy, and oxidative stress in neurodegenerative diseases.

    abstract::The etiology of neurodegenerative diseases remains enigmatic; however, evidence for defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly compelling. It is likely that there is a complex interplay between these mechanisms. A defect in energy metabolism may lead to neuronal depolarizati...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Beal MF

    更新日期:1995-09-01 00:00:00

  • Association of IgM type anti-GM1 antibodies and muscle strength in chronic acquired demyelinating polyneuropathy.

    abstract::The pathogenetic role of anti-GM1 in chronic acquired demyelinating polyneuropathy (CADP) is uncertain. An association between antibodies and disease activity has not yet been established. In 8 patients with CADP followed longitudinally, anti-GM1 antibodies were monitored with a standardized enzyme-linked immunosorben...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bech E,Andersen H,Orntoft TF,Jakobsen J

    更新日期:1998-01-01 00:00:00

  • A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.

    abstract::Mutations in AbetaPP cause deposition of Abeta amyloid fibrils in brain parenchyma and cerebral vessels, resulting in Alzheimer's disease (AD) and/or cerebral amyloid angiopathy (CAA). We report a novel mutation (L705V) within the Abeta sequence of AbetaPP in a family with autosomal dominant, recurrent intracerebral h...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Obici L,Demarchi A,de Rosa G,Bellotti V,Marciano S,Donadei S,Arbustini E,Palladini G,Diegoli M,Genovese E,Ferrari G,Coverlizza S,Merlini G

    更新日期:2005-10-01 00:00:00

  • Botulism, type A, and treatment with guanidine.

    abstract::In a double-blind crossover study in which patients received placebo or active drug for varying periods, we evaluated the ability of guanidine hydrochloride (20 to 35 mg/kg per day perorally) to improve the rate of recovery in patients with moderate or severe botulism, type A, intoxication. Among 14 patients who recei...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章


    authors: Kaplan JE,Davis LE,Narayan V,Koster J,Katzenstein D

    更新日期:1979-07-01 00:00:00