Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.

Abstract:

:Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Askanas V,Alvarez RB,Mirabella M,Engel WK

doi

10.1002/ana.410390318

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

389-91

issue

3

eissn

0364-5134

issn

1531-8249

journal_volume

39

pub_type

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