Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.

Abstract:

:Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Askanas V,Alvarez RB,Mirabella M,Engel WK

doi

10.1002/ana.410390318

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

389-91

issue

3

eissn

0364-5134

issn

1531-8249

journal_volume

39

pub_type

杂志文章
  • Epilepsy in adults.

    abstract::The past decade has seen advances in the management of patients with epilepsy. The development of practical long-term electroencephalographic techniques, with or without simultaneous video recording, has increased the accuracy of diagnosis of seizure types. The technique also provides clinicians and investigators with...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审

    doi:10.1002/ana.410090103

    authors: So EL,Penry JK

    更新日期:1981-01-01 00:00:00

  • A peek behind the curtain: peer review and editorial decision making at Stroke.

    abstract:OBJECTIVE:A better understanding of the manuscript peer-review process could improve the likelihood that research of the highest quality is funded and published. To this end, we aimed to assess consistency across reviewers' recommendations, agreement between reviewers' recommendations and editors' final decisions, and ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.24218

    authors: Sposato LA,Ovbiagele B,Johnston SC,Fisher M,Saposnik G,Stroke Outcome Research Working Group (www.sorcan.ca).

    更新日期:2014-08-01 00:00:00

  • A disconnection account of Gerstmann syndrome: functional neuroanatomy evidence.

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    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21776

    authors: Rusconi E,Pinel P,Eger E,LeBihan D,Thirion B,Dehaene S,Kleinschmidt A

    更新日期:2009-11-01 00:00:00

  • Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies.

    abstract:OBJECTIVE:Blunted tachycardia during hypotension is a characteristic feature of patients with autonomic failure, but the range has not been defined. This study reports the range of orthostatic heart rate (HR) changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. METHODS:Patients eva...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25170

    authors: Norcliffe-Kaufmann L,Kaufmann H,Palma JA,Shibao CA,Biaggioni I,Peltier AC,Singer W,Low PA,Goldstein DS,Gibbons CH,Freeman R,Robertson D,Autonomic Disorders Consortium.

    更新日期:2018-03-01 00:00:00

  • Sensory nerve pathology in multifocal motor neuropathy.

    abstract::The nosological status of multifocal motor neuropathy remains controversial. The clinical and electrodiagnostic hallmarks suggest selective motor fiber involvement. In this study, we asked to what extent sensory nerves might be involved pathologically in multifocal motor neuropathy. Examination of sensory nerve biopsy...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410390308

    authors: Corse AM,Chaudhry V,Crawford TO,Cornblath DR,Kuncl RW,Griffin JW

    更新日期:1996-03-01 00:00:00

  • Congenital muscular dystrophy with primary laminin alpha2 (merosin) deficiency presenting as inflammatory myopathy.

    abstract::Ten laminin alpha2-deficient patients were identified by both immunofluorescence and immunoblotting (30% of congenital muscular dystrophy patients tested). Three of the laminin alpha2-deficient patients were carrying a diagnosis of infantile polymyositis prior to immunostaining studies. The clinical features in the 10...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410400515

    authors: Pegoraro E,Mancias P,Swerdlow SH,Raikow RB,Garcia C,Marks H,Crawford T,Carver V,Di Cianno B,Hoffman EP

    更新日期:1996-11-01 00:00:00

  • Sensory discrimination capabilities in patients with focal hand dystonia.

    abstract::To explore the concept that dystonia may result from dysfunction of the sensory system, 14 patients with focal hand dystonia were tested during two somatosensory discrimination tasks. Compared with controls, patients had a higher threshold in a task involving discrimination of two electric stimuli closely related temp...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:

    authors: Bara-Jimenez W,Shelton P,Sanger TD,Hallett M

    更新日期:2000-03-01 00:00:00

  • The pressure difference between eye and brain changes with posture.

    abstract:OBJECTIVE:The discovery of a posture-dependent effect on the difference between intraocular pressure (IOP) and intracranial pressure (ICP) at the level of lamina cribrosa could have important implications for understanding glaucoma and idiopathic intracranial hypertension and could help explain visual impairments in as...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.24713

    authors: Eklund A,Jóhannesson G,Johansson E,Holmlund P,Qvarlander S,Ambarki K,Wåhlin A,Koskinen LO,Malm J

    更新日期:2016-08-01 00:00:00

  • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions.

    abstract::Orally administered levodopa remains the most effective symptomatic treatment for Parkinson's disease (PD). The introduction of levodopa therapy is often delayed, however, because of the fear that it might be toxic for the remaining dopaminergic neurons and, thus, accelerate the deterioration of patients. However, in ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410430504

    authors: Murer MG,Dziewczapolski G,Menalled LB,García MC,Agid Y,Gershanik O,Raisman-Vozari R

    更新日期:1998-05-01 00:00:00

  • Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis.

    abstract::Magnetic resonance imaging (MRI) provides a powerful tool for assessing disease activity in multiple sclerosis (MS), and its role as a surrogate marker for monitoring treatment efficacy is now becoming established. The most commonly used MRI parameters in treatment trials are (1) monthly gadolinium-enhanced MRI, with ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审

    doi:10.1002/ana.410430311

    authors: Molyneux PD,Filippi M,Barkhof F,Gasperini C,Yousry TA,Truyen L,Lai HM,Rocca MA,Moseley IF,Miller DH

    更新日期:1998-03-01 00:00:00

  • A Trial of Sertraline or Cognitive Behavior Therapy for Depression in Epilepsy.

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    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ana.25561

    authors: Gilliam FG,Black KJ,Carter J,Freedland KE,Sheline YI,Tsai WY,Lustman PJ

    更新日期:2019-10-01 00:00:00

  • DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.

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    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.24656

    authors: Bettencourt C,Hensman-Moss D,Flower M,Wiethoff S,Brice A,Goizet C,Stevanin G,Koutsis G,Karadima G,Panas M,Yescas-Gómez P,García-Velázquez LE,Alonso-Vilatela ME,Lima M,Raposo M,Traynor B,Sweeney M,Wood N,Giunti P,SPA

    更新日期:2016-06-01 00:00:00

  • Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.

    abstract::We previously reported a marked increase of a 20,000 molecular weight (MW) protein, P20, in some neuronal fractions and whole cortical homogenates isolated from affected cortex in Alzheimer disease; P20 comigrated electrophoretically with an unidentified, major 20,000 MW protein present in human neurofilament (NF) fra...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410100505

    authors: Selkoe DJ,Brown BA,Salazar FJ,Marotta CA

    更新日期:1981-11-01 00:00:00

  • The first decade of molecular genetics in neurology: changing clinical thought and practice.

    abstract::Molecular genetics has had a powerful impact on clinical neurology. Definitions of disease are changing from clinical criteria to DNA analysis, resolving questions about the nature of clinically similar but not identical diseases. Genetic counseling is more reliable. Concepts of mendelian inheritance are being tested ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审

    doi:10.1002/ana.410320213

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  • Imaging correlates of axonal swelling in chronic multiple sclerosis brains.

    abstract:OBJECTIVE:T2-weighted magnetic resonance imaging is a sensitive tool for monitoring progression of multiple sclerosis, but it does not provide information on the severity of the underlying tissue damage. Measurement of T1 hypointensities and magnetization transfer ratio (MTR) can potentially distinguish lesions with mo...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21113

    authors: Fisher E,Chang A,Fox RJ,Tkach JA,Svarovsky T,Nakamura K,Rudick RA,Trapp BD

    更新日期:2007-09-01 00:00:00

  • Stimulus rate determines regional brain blood flow in striate cortex.

    abstract::Intravenous bolus administration of oxygen 15-labeled water and positron emission tomography were used to measure changes in brain blood flow induced by two modes of photic stimuli over a wide range of repetition rates. These stimuli (patterned-flash and reversing checkerboard) were chosen in order to determine whethe...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410170315

    authors: Fox PT,Raichle ME

    更新日期:1985-03-01 00:00:00

  • MELAS: clinical features, biochemistry, and molecular genetics.

    abstract::We studied 23 patients with clinically defined mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), 25 oligosymptomatic or asymptomatic maternal relatives, and 50 mitochondrial disease control subjects for the presence of a previously reported heteroplasmic point mutation at nt 3,243 in ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410310408

    authors: Ciafaloni E,Ricci E,Shanske S,Moraes CT,Silvestri G,Hirano M,Simonetti S,Angelini C,Donati MA,Garcia C

    更新日期:1992-04-01 00:00:00

  • Failure of chronic dorsal column stimulation in multiple sclerosis.

    abstract::In view of the favorable claims of Cook and others, an open trial of chronic dorsal column stimulation was undertaken in 9 patients who had moderately advanced multiple sclerosis (MS) but were still ambulatory. No objective improvement was noted by either author during the postoperative observation period of 6 to 37 m...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410060115

    authors: Rosen JA,Barsoum AH

    更新日期:1979-07-01 00:00:00

  • Site of autonomic deficit in harlequin syndrome: local autonomic failure affecting the arm and the face.

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    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410340610

    authors: Drummond PD,Lance JW

    更新日期:1993-12-01 00:00:00

  • Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants.

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    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ana.21766

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    更新日期:2009-11-01 00:00:00

  • Positron emission tomography studies on the dopaminergic system and striatal opioid binding in the olivopontocerebellar atrophy variant of multiple system atrophy.

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    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410370505

    authors: Rinne JO,Burn DJ,Mathias CJ,Quinn NP,Marsden CD,Brooks DJ

    更新日期:1995-05-01 00:00:00

  • Phenobarbital modifies seizure-related brain injury in the developing brain.

    abstract::To investigate the potential role of drug therapy in preventing or exacerbating seizure-related brain injury in the prepubescent brain, we administered kainic acid to rats at postnatal day 35. Therapy with daily phenobarbital was started directly before or 1 day after kainic acid was administered, and was continued th...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410360314

    authors: Mikati MA,Holmes GL,Chronopoulos A,Hyde P,Thurber S,Gatt A,Liu Z,Werner S,Stafstrom CE

    更新日期:1994-09-01 00:00:00

  • Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.

    abstract::Increased glutamatergic transmission in the basal ganglia is implicated in the pathophysiology of Parkinson's disease. However, the mechanisms by which activation of glutamate receptors produce parkinsonism are unknown. Therefore, we examined whether the glutamate agonists N-methyl-D-aspartate (NMDA), alpha-amino-3-hy...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410340413

    authors: Klockgether T,Turski L

    更新日期:1993-10-01 00:00:00

  • Prevention of experimental allergic encephalomyelitis in Lewis rats with peptide 68-88 of guinea pig myelin basic protein.

    abstract::The highly encephalitogenic guinea pig peptide 68-88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmol of the peptide in complete Fre...

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    pub_type: 杂志文章

    doi:10.1002/ana.410070409

    authors: Chou FC,Chou CH,Fritz RB,Kibler RF

    更新日期:1980-04-01 00:00:00

  • Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51.

    abstract::We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA-B51 in common. This finding suggests that there may be a genetic predisposition for "idiopathic" childhood stroke, and host factors, possibly in concert with environmental f...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410310618

    authors: Mintz M,Epstein LG,Koenigsberger MR

    更新日期:1992-06-01 00:00:00

  • Serological alpha 1-antichymotrypsin in Down's syndrome and Alzheimer's disease.

    abstract::alpha 1-Antichymotrypsin (ACT) is a serine protease inhibitor that is markedly elevated in the serum and cerebrospinal fluid of patients with Alzheimer's disease (AD). Patients with Down's syndrome are known to develop neuropathological changes of AD by age 40 years and many become demented. Therefore, in the present ...

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    pub_type: 杂志文章

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    更新日期:1992-08-01 00:00:00

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    authors: Nazeri A,Roostaei T,Sadaghiani S,Chakravarty MM,Eberly S,Lang AE,Voineskos AN

    更新日期:2015-11-01 00:00:00

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    pub_type: 杂志文章

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    authors: Panayiotopoulos CP,Obeid T,Waheed G

    更新日期:1989-04-01 00:00:00