Use of anti-neurofilament antibody to identify paired-helical filaments in inclusion-body myositis.


:Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates diagnosis of IBM.


Ann Neurol


Annals of neurology


Askanas V,Alvarez RB,Mirabella M,Engel WK




Has Abstract


1996-03-01 00:00:00












  • Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.

    abstract:OBJECTIVE:Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families remain genetically unsolved, and the underlying molecular mechan...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Dazzo E,Rehberg K,Michelucci R,Passarelli D,Boniver C,Vianello Dri V,Striano P,Striano S,Pasterkamp RJ,Nobile C

    更新日期:2018-03-01 00:00:00

  • Phenotypic expression of the DYT1 mutation: a family with writer's cramp of juvenile onset.

    abstract::Recently, the mutation causing early-onset generalized torsion dystonia has been identified as a GAG deletion in the gene for an adenosine triphosphate-binding protein named torsinA. We describe a German family with 5 clinically affected individuals carrying this mutation. In at least 4 of the 5 patients, the disease ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Gasser T,Windgassen K,Bereznai B,Kabus C,Ludolph AC

    更新日期:1998-07-01 00:00:00

  • Apolipoprotein E and alpha1-antichymotrypsin polymorphism in Alzheimer's disease.

    abstract::A recent observation has shown that a common polymorphism in the alpha1-antichymotrypsin (ACT) gene modifies the apolipoprotein E (ApoE) epsilon4-associated Alzheimer's disease (AD) risk identifying the combination of the ACT/AA and ApoE epsilon4/epsilon4 genotypes as a potential susceptibility marker for AD. We analy...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Nacmias B,Tedde A,Latorraca S,Piacentini S,Bracco L,Amaducci L,Guarnieri BM,Petruzzi C,Ortenzi L,Sorbi S

    更新日期:1996-10-01 00:00:00

  • Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging.

    abstract:OBJECTIVE:Predicting hemorrhagic transformation (HT) is critical in the setting of recanalization therapy for acute stroke. Dedicated magnetic resonance imaging (MRI) sequences for detection of increased blood-brain barrier (BBB) permeability recently have been developed. We evaluated the ability of a novel MRI permeab...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bang OY,Buck BH,Saver JL,Alger JR,Yoon SR,Starkman S,Ovbiagele B,Kim D,Ali LK,Sanossian N,Jahan R,Duckwiler GR,Viñuela F,Salamon N,Villablanca JP,Liebeskind DS

    更新日期:2007-08-01 00:00:00

  • Glutamate receptor-mediated ischemic injury of premyelinated central axons.

    abstract:OBJECTIVE:Ischemic injury of axons is a feature of periventricular leukomalacia, a pathological correlate of cerebral palsy. Recent evidence suggests that axons are damaged before they receive the first layer of compact myelin. Here we examine the cellular mechanisms underlying ischemic-type injury of premyelinated cen...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Alix JJ,Fern R

    更新日期:2009-11-01 00:00:00

  • Chronic opioid therapy as alternative treatment for post-herpetic neuralgia.

    abstract::Neurosurgical procedures such as the dorsal root entry zone operation, ganglionectomy, and spinal-cord stimulation have been offered to patients with intractable post-herpetic neuralgia (PHN). Poor efficacy or high morbidity have limited the overall usefulness of these procedures. We recently conducted a preliminary o...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Pappagallo M,Campbell JN

    更新日期:1994-01-01 00:00:00

  • Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b.

    abstract::We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar-binding lectin suggested that the epitope in the patient's M-IgM involved the Gal(beta 1-3) GalNAc moiety. Immunohistological techniques demonstrate...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Nardelli E,Steck AJ,Barkas T,Schluep M,Jerusalem F

    更新日期:1988-05-01 00:00:00

  • Corticostriatal plasticity is restricted by myelin-associated neurite growth inhibitors in the adult rat.

    abstract::After unilateral cortical lesions in neonatal rats, the spared unablated hemisphere is known to demonstrate remarkable neuroanatomical plasticity in corticofugal connectivity. This same type of structural plasticity is not seen after similar lesions in adult rats. One possibility for the lack of such a plastic respons...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kartje GL,Schulz MK,Lopez-Yunez A,Schnell L,Schwab ME

    更新日期:1999-06-01 00:00:00

  • Cerebrospinal fluid vasopressin and increased intracranial pressure.

    abstract::Cerebrospinal fluid and plasma vasopressin were measured in patients with cerebral disorders associated with varying levels of elevated intracranial pressure. The mean cerebrospinal fluid vasopressin concentration was significantly increased in patients with pseudotumor cerebri (2.0 +/- 0.2 [SEM] pg/ml), intracranial ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Sørensen PS,Gjerris F,Hammer M

    更新日期:1984-05-01 00:00:00

  • The effect of metrizamide on the electroencephalogram: a prospective study in 61 patients.

    abstract::A prospective study was made of changes in the electroencephalogram after the use of metrizamide for myelography and posterior fossa cisternography in 61 patients (62 studies). The EEG changed in 21 patients (34%); 3 of these had had previously abnormal records, and the abnormalities were accentuated on the second rec...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Ropper AH,Chiappa KH,Young RR

    更新日期:1979-09-01 00:00:00

  • Seizures during barbiturate withdrawal: relation to blood level.

    abstract::We studied 21 patients with complex partial seizures during phenobarbital (PB) or primidone withdrawal. Blood levels were measured daily, and seizure frequency was monitored by nursing staff and EEG-video telemetry. Patients were monitored for one week of baseline and for five weeks after PB tapering was initiated (wi...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Theodore WH,Porter RJ,Raubertas RF

    更新日期:1987-11-01 00:00:00

  • Multiple sclerosis and viruses.

    abstract::Discussing the problem of multiple sclerosis and viruses should not be limited to reviewing the epidemiological evidence in favor, or against, a particular candidate, such as Epstein-Barr virus or human herpes virus 6. In this text, I discuss the difficulty of going from association to causation in human epidemiology;...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Brahic M

    更新日期:2010-07-01 00:00:00

  • Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction.

    abstract::Disorders of neuronal migration in cerebral cortex are associated with neurological impairments, including mental retardation and epilepsy. Their causes and pathophysiology remain largely unknown, however. In patients with Zellweger disease, a lethal panperoxisomal disorder, and in mice lacking the Pxr1 import recepto...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Gressens P,Baes M,Leroux P,Lombet A,Van Veldhoven P,Janssen A,Vamecq J,Marret S,Evrard P

    更新日期:2000-09-01 00:00:00

  • Conjugal multiple sclerosis: population-based prevalence and recurrence risks in offspring. Canadian Collaborative Study Group.

    abstract::From a population-based sample of 15,504 patients attending Canadian multiple sclerosis (MS) clinics, we have determined the frequency of conjugal MS and have estimated the recurrence risk in offspring of such matings. Twenty-three MS cases were found among 13,550 spouses of study probands for a crude conjugal rate of...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Ebers GC,Yee IM,Sadovnick AD,Duquette P

    更新日期:2000-12-01 00:00:00

  • Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.

    abstract:OBJECTIVE:Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an elect...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Piallat B,Polosan M,Fraix V,Goetz L,David O,Fenoy A,Torres N,Quesada JL,Seigneuret E,Pollak P,Krack P,Bougerol T,Benabid AL,Chabardès S

    更新日期:2011-05-01 00:00:00

  • Passive joint position sense after total hip replacement surgery.

    abstract::Passive joint position sense was tested in 10 subjects after unilateral total hip replacement surgery (which included capsulectomy). Varied initial limb position, amplitude, and velocity of movement were used. The unoperated side was used as a control. Statistically barely significant errors (p less than 0.025) on the...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Karanjia PN,Ferguson JH

    更新日期:1983-06-01 00:00:00

  • Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.

    abstract::Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Sriram S,Steiner I

    更新日期:2005-12-01 00:00:00

  • Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates.

    abstract::To examine the antiparkinsonian effects of blocking glycineB receptors, we designed a pilot study testing the potent and selective antagonist, PAMQX, in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. PAMQX had no intrinsic effects but markedly potentiated the antiparkinsonian action of levodopa. In a d...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Papa SM,Auberson YP,Greenamyre JT

    更新日期:2004-11-01 00:00:00

  • B-cell Therapy for Multiple Sclerosis: Entering an era.

    abstract::Monoclonal antibodies that target CD20 expressing B cells represent an important new treatment option for patients with multiple sclerosis (MS). B-cell-depleting therapy is highly effective against relapsing forms of the disease and is also the first treatment approach proven to protect against disability worsening in...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Greenfield AL,Hauser SL

    更新日期:2018-01-01 00:00:00

  • The response to levodopa in Parkinson's disease: imposing pharmacological law and order.

    abstract::The seemingly unpredictable response to levodopa in patients with Parkinson's disease can be understood as an interaction between several distinct pharmacological effects of levodopa. The most important are a short-duration response with a half-life of minutes to hours and a long-duration response with a half-life of ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Nutt JG,Holford NH

    更新日期:1996-05-01 00:00:00

  • Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.

    abstract:OBJECTIVE:Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system. Although the clinical impact of gray matter pathology in MS brains is unknown, 30 to 40% of MS patients demonstrate memory impairment. The molecular basis of this memory dysfunction has not yet been investiga...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Dutta R,Chang A,Doud MK,Kidd GJ,Ribaudo MV,Young EA,Fox RJ,Staugaitis SM,Trapp BD

    更新日期:2011-03-01 00:00:00

  • The initial diagnosis of multiple sclerosis: clinical impact of magnetic resonance imaging.

    abstract::Thirty patients in whom the initial diagnosis of multiple sclerosis was clinically entertained underwent cranial magnetic resonance imaging (MRI) in close temporal relationship to cranial x-ray computed tomography (CT), electrodiagnostic studies (visual evoked responses, brainstem auditory evoked responses, and somato...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Gebarski SS,Gabrielsen TO,Gilman S,Knake JE,Latack JT,Aisen AM

    更新日期:1985-05-01 00:00:00

  • Familial myoclonic dementia masquerading as Creutzfeldt-Jakob disease.

    abstract::We describe a kindred with 7 confirmed and 2 probable cases of subacute dementia accompanied by myoclonus. The inheritance pattern is consistent with autosomal dominance and shows anticipation. The pathological changes involve marked gliosis with neuronal loss of the dorsomedial and midline thalamic nuclei, with lesse...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Little BW,Brown PW,Rodgers-Johnson P,Perl DP,Gajdusek DC

    更新日期:1986-08-01 00:00:00

  • Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis.

    abstract::Recently, variant mRNA transcripts for the astroglial glutamate transporter EAAT2 have been detected in brain tissues of 60% of patients with sporadic amyotrophic lateral sclerosis (SALS). We have tested the hypothesis that the gene for EAAT2 may be defective in some ALS cases. In 16 familial ALS (FALS) pedigrees with...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Aoki M,Lin CL,Rothstein JD,Geller BA,Hosler BA,Munsat TL,Horvitz HR,Brown RH Jr

    更新日期:1998-05-01 00:00:00

  • Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis.

    abstract::Magnetic resonance imaging is a highly sensitive method for the detection of the lesions of multiple sclerosis and renders possible the study and the evolution of early lesions. Previous reports on magnetic resonance imaging following gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) injection demonstrated that...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Katz D,Taubenberger JK,Cannella B,McFarlin DE,Raine CS,McFarland HF

    更新日期:1993-11-01 00:00:00

  • Dysferlin overexpression in skeletal muscle produces a progressive myopathy.

    abstract:OBJECTIVE:The dose-response effects of dysferlin transgenesis were analyzed to determine if the dysferlin-deficient myopathies are good candidates for gene replacement therapy. METHODS:We have generated 3 lines of transgenic mice, expressing low, mid, and high levels of full-length human dysferlin from a muscle-specif...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Glover LE,Newton K,Krishnan G,Bronson R,Boyle A,Krivickas LS,Brown RH Jr

    更新日期:2010-03-01 00:00:00

  • Free amino acid levels in amyotrophic lateral sclerosis.

    abstract::To evaluate reports of abnormal levels of free amino acids (AA) in patients with amyotrophic lateral sclerosis (ALS), we studied serum, cerebrospinal fluid, and urine AA in 12 patients with ALS and 12 controls matched for age, sex, and severity of disability. ALS patients had statistically significant elevations in se...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Patten BM,Harati Y,Acosta L,Jung SS,Felmus MT

    更新日期:1978-04-01 00:00:00

  • Adrenoleukodystrophy: a correlation between saturated very long-chain fatty acids in mononuclear cells and phenotype.

    abstract::Saturated very long-chain fatty acids in erythrocyte membranes, blood plasma, and mononuclear cells were studied in 4 patients with childhood-adolescent adrenoleukodystrophy and 4 patients with adult adrenoleukodystrophy and 19 normal control subjects by using high-performance liquid chromatography. Ratios of C26:0 to...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Antoku Y,Koike F,Ohtsuka Y,Sakai T,Tsukamoto K,Nagara H,Iwashita H,Goto I

    更新日期:1991-07-01 00:00:00

  • IgG production within the central nervous system: a critical review of proposed formulae.

    abstract::Demonstration of intrathecal IgG production is employed in the diagnosis of various neurological disorders. This pathological IgG fraction in cerebrospinal fluid (CSF) can be visualized directly as oligoclonal bands by electrophoresis or isoelectric focusing or can be calculated as "excess" or "synthesized" IgG accord...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Lefvert AK,Link H

    更新日期:1985-01-01 00:00:00

  • Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.

    abstract::To identify those factors associated with cerebral hemorrhage among brains with cerebral amyloid angiopathy (CAA), we undertook a comparative postmortem histopathological study of amyloid-containing vessels in the brains of patients with and without hemorrhage. Those without hemorrhage were represented by the followin...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Vonsattel JP,Myers RH,Hedley-Whyte ET,Ropper AH,Bird ED,Richardson EP Jr

    更新日期:1991-11-01 00:00:00