Abstract：
BACKGROUND:We explored health-related quality of life (HRQoL) and psychosocial aspects in a cohort of patients with a history of longstanding benign MS (BMS). METHODS:Patients with BMS (EDSS≤3 after 20 years disease duration) were re-assessed 25-30 years post-MS symptom onset for: EDSS, HRQoL (MSQoL-54), depression (Beck Depression Inventory-II), and fatigue (Modified Fatigue Impact Scale). Associations between these measures and patient characteristics (age, disease duration, 'benign status' [remained benign (EDSS≤3) vs no longer benign (EDSS>3)]) were examined. RESULTS:Of the 61 patients included, 36 (49%) remained benign and 25 (41%) progressed (EDSS>3). Overall, physical and mental HRQoL scores were positively associated with each other (r=0.63; p<0.0001) and both negatively correlated with fatigue (r=-0.76 and -0.44, respectively; p<0.0005) and depression (r=-0.55 and -0.77; p<0.0001). Patients who remained benign reported better physical HRQoL vs those no longer benign (mean (SD)=67.3±18.1 vs 50.7±19.9, p=0.001), but not mental health (mean (SD)=67.4±19.3 vs 65.0±20.6, p=0.639). Generally, neither age nor disease duration was strongly associated with HRQoL (r<0.35). CONCLUSION:Lower self-reported physical or mental HRQoL was associated with worsening fatigue and depression. However, EDSS progression was associated with the physical, but not mental aspects of HRQoL. Patient-reported HRQoL in 'benign MS' provides insight on the impact of MS beyond EDSS alone.
journal_name
Mult Scler Relat Disordjournal_title
Multiple sclerosis and related disordersauthors
Bueno AM,Sayao AL,Yousefi M,Devonshire V,Traboulsee A,Tremlett Hdoi
10.1016/j.msard.2014.09.211subject
Has Abstractpub_date
2015-01-01 00:00:00pages
31-8issue
1eissn
2211-0348issn
2211-0356pii
S2211-0348(14)00315-0journal_volume
4pub_type
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journal_title：Multiple sclerosis and related disorders
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journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章,评审
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journal_title：Multiple sclerosis and related disorders
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journal_title：Multiple sclerosis and related disorders
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journal_title：Multiple sclerosis and related disorders
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journal_title：Multiple sclerosis and related disorders
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journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章
doi：10.1016/j.msard.2016.10.009
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journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章,评审
doi：10.1016/j.msard.2017.01.010
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journal_title：Multiple sclerosis and related disorders
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pub_type： 杂志文章,评审
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journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章
doi：10.1016/j.msard.2012.02.004
更新日期：2012-07-01 00:00:00
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journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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doi：10.1016/j.msard.2020.102182
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abstract：BACKGROUND:Impairments in long-term and working memory are widespread in Multiple Sclerosis (MS), setting on in early disease stages. These memory impairments may limit patients' ability to take informed and competent medical decisions, too. In healthy populations, memory abilities predict decision quality across a wid...
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Cognitive dysfunctions are very frequent in people living with multiple sclerosis (MS). Several studies have previously indicated grey matter (GM) atrophy as useful predictor of patients' cognitive impairment. However, considerable uncertainty exists about the possible impact of deep grey matter volumes on c...
journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章
doi：10.1016/j.msard.2020.102351
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abstract：BACKGROUND:Cerebrospinal fluid (CSF) levels of neurofilament light (NFL), a biomarker of axonal damage, and CXCL13, a chemokine involved in B-cell regulation, are both associated with disease activity in multiple sclerosis (MS). OBJECTIVE:To explore the potential of NFL and CXCL13 to detect residual disease activity i...
journal_title：Multiple sclerosis and related disorders
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更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Multiple Sclerosis (MS) is a degenerative disease of central nervous system caused by an immune response against the myelin. About half of MS patients suffers from sleep disturbances. The circadian clock genes such as PER3 controls circadian rhythm and sleep. Due to the role of PER3 in sleep disturbances and...
journal_title：Multiple sclerosis and related disorders
pub_type： 杂志文章
doi：10.1016/j.msard.2017.07.005
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abstract：BACKGROUND:Balance impairment is common and a risk factor of falls in people with multiple sclerosis (MS). The purpose of this study was to evaluate the relative importance between vision and proprioception in maintaining standing body balance among individuals with MS compared with healthy individuals. METHODS:Thirty...
journal_title：Multiple sclerosis and related disorders
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