Abstract:
BACKGROUND:Functional electrical stimulation (FES) is commonly used to ameliorate gait deficits in patients with multiple sclerosis (PwMS). This review critically evaluates the literature describing the orthotic and therapeutic effects of FES on gait in PwMS. METHODS:The PubMed, CINAHL, and ProQuest databases were searched. Included were studies that evaluated therapeutic and/or orthotic effects of FES in PwMS with at least one outcome measure related to gait. Methodology was assessed using the Downs and Black checklist. RESULTS:Twelve relevant studies were reviewed. Their methodological quality ranged from 14 to 21 of 28. Eleven studies reported the effects of peroneal stimulation. Most found a significant orthotic effect (measured during stimulation), mainly on walking speed. Only three assessed the therapeutic effect (carry-over), which was not significant. CONCLUSIONS:The evidence presented in this review suggests that FES has a positive orthotic effect on walking in PwMS. Yet, more robust trials are needed to substantiate this finding. Therapeutic efficacy of FES was not demonstrated, and almost all studies tested a single channel peroneal stimulator. Future studies involving FES technological innovations with advanced clinical approaches might contribute to a carry-over effect from FES and increase the percentage of PwMS who benefit from this technology.
journal_name
Mult Scler Relat Disordjournal_title
Multiple sclerosis and related disordersauthors
Springer S,Khamis Sdoi
10.1016/j.msard.2017.01.010subject
Has Abstractpub_date
2017-04-01 00:00:00pages
4-12eissn
2211-0348issn
2211-0356pii
S2211-0348(17)30011-1journal_volume
13pub_type
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.msard.2018.09.014
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.09.039
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2020.102131
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2019.101901
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.07.002
更新日期:2018-08-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 信件
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2013.09.004
更新日期:2014-03-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2016.12.009
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2019.06.026
更新日期:2019-09-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2019.101433
更新日期:2020-01-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2017.06.001
更新日期:2017-08-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2019.04.001
更新日期:2019-06-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.06.003
更新日期:2018-08-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2017.02.016
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Fingolimod (FTY720) has been approved as the first oral representative of the class of sphingosine-1-phosphate (S1P) receptor modulators for the treatment of relapsing-remitting multiple sclerosis (MS). Besides inducing vaso-relaxation, fingolimod can also influence electrical conduction in the myocardium an...
journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
doi:10.1016/j.msard.2016.04.002
更新日期:2016-07-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
doi:10.1016/j.msard.2019.101452
更新日期:2020-01-01 00:00:00
abstract::Fingolimod, taken orally once per day, is approved for the treatment of relapsing-remitting multiple sclerosis (MS). It should be stopped at least two months before conception as it is not considered safe during pregnancy or when breast feeding. In vitro and animal studies have found a possibly increased risk of conge...
journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.02.015
更新日期:2018-04-01 00:00:00