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Clinical decision-making in multiple sclerosis: Challenges reported internationally with emerging treatment complexity.

Abstract：

INTRODUCTION:The introduction of several new disease-modifying therapies (DMTs) to the field of Multiple Sclerosis (MS) treatment requires that MS healthcare providers have a comprehensive understanding of the implications of each new treatment option in order to select the treatment that best suits their patient. An international study was conducted in 6 countries to obtain a better understanding of the issues and challenges experienced by Neurologists and Nurses in the treatment and management of their patients with MS. The goal of this research was to obtain evidence to inform future Continuing Medical Education (CME) initiatives and health policies that promote knowledge translation to clinical practice. This article focuses on challenges reported in relation to the use of newly approved therapies, in light of the risks of these new treatments, as well as screening and monitoring precautions that must be taken. MATERIALS AND METHODS:An exploratory study and literature review informed the design of an IRB-approved online survey deployed to MS Neurologists and Nurses practicing in 6 countries (Germany, France, Italy, Spain, UK, USA). RESULTS:The sample consisted of actively practicing Neurologists (n=156) and Nurses (n=153). Substantive challenges were reported in participant's knowledge of and confidence in three categories: i) safety profile of newly approved therapies, ii) screening patients for treatment with newly approved therapies, and iii) monitoring for serious adverse events. DISCUSSION AND CONCLUSION:Findings indicate that, internationally, healthcare providers report substantive challenges integrating newly approved therapies into their clinical decision-making. This study highlights potential factors underlying the challenges, and identifies important targets for CME interventions and policymakers to enhance clinical decision-making amongst MS providers.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Ng P,Murray S,Hayes SM

doi

10.1016/j.msard.2015.05.008

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

320-8

issue

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(15)00068-1

journal_volume

pub_type

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Clinical decision-making in multiple sclerosis: Challenges reported internationally with emerging treatment complexity.