当前位置： SCI文献检索 > Multiple Sclerosis and Related Disorders期刊下所有文献 > The impact of deep grey matter volume on cognition in multiple sclerosis.

The impact of deep grey matter volume on cognition in multiple sclerosis.

Abstract：

BACKGROUND:Cognitive dysfunctions are very frequent in people living with multiple sclerosis (MS). Several studies have previously indicated grey matter (GM) atrophy as useful predictor of patients' cognitive impairment. However, considerable uncertainty exists about the possible impact of deep grey matter volumes on cognition. This study aimed to evaluate the relationship of the subcortical (sc) GM volumes with the presence and severity of global and selective cognitive impairment in MS. METHODS:A group of MS patients with relapsing remitting course were enrolled. Patients underwent a neuropsychological evaluation by using the Brief Repeatable Battery of Neuropsychological Tests (BRBN) and the Delis-Kaplan Executive Function System Sorting Test (D-KEFST); z scores were estimated and items with z score below 2 standard deviation were considered failed. Thus, brain MRIs images were acquired and measurements of whole brain (WB), white matter (WM), and cortical grey matter (GM) were obtained by SIENAX. After FIRST tool segmentation, volumes of subcortical GM structures were also estimated. RESULTS:The sample included 50 MS patients, of which 16/50 (32%) subjects were cognitively impaired. Multiple regression analyses found a significant association of severity of cognitive impairment, defined as number of failed neuropsychological tests, with lower volumes of cortex (p=0.003), thalamus (p=0.009), caudate (p=0.011), putamen (p=0.020), pallidus (p=0.012) and hippocampus (p=0.045), independently from other MS features. In addition, an association between accumbens volume and D-KEFS ST FSC and D-KEFS ST FSD z scores was observed (p<0.03). CONCLUSIONS:Our results indicated that volumes of several scGM structures, and in particular of thalamus, contribute to determine cognitive dysfunctions in MS, mainly influencing the executive functioning. Further investigations in larger MS cohorts with cognitive impairment are necessary to better understand the structural brain damage underlying this "invisible disability".

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Lorefice L,Carta E,Frau J,Contu F,Casaglia E,Coghe G,Barracciu MA,Cocco E,Fenu G

doi

10.1016/j.msard.2020.102351

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

102351

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(20)30426-0

journal_volume

45

pub_type

杂志文章

相关文献

Multiple Sclerosis and Related Disorders文献大全
  • Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis.

    abstract：BACKGROUND:Numerous factors can affect multiple sclerosis (MS) patients' quality of life (QoL). We investigated how physical impairment, upper extremity function, cognitive impairment, cognitive reserve, symptoms of psychological distress, depression, fatigue as well as age and disease duration contribute to patient-re...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.049

    authors： Yalachkov Y,Soydaş D,Bergmann J,Frisch S,Behrens M,Foerch C,Gehrig J

    更新日期：2019-05-01 00:00:00

  • Weight status and disability in multiple sclerosis: An examination of bi-directional associations over a 24-month period.

    abstract：BACKGROUND:Natural history studies have typically focused on non-modifiable factors as predictors of disability progression in multiple sclerosis (MS). Weight status has emerged as a correlate of disability status in cross-sectional studies of persons with MS and represents a possible modifiable predictor of disability...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2012.02.004

    authors： Pilutti LA,McAuley E,Motl RW

    更新日期：2012-07-01 00:00:00

  • Robot-guided ankle sensorimotor rehabilitation of patients with multiple sclerosis.

    abstract：BACKGROUND:People with multiple sclerosis (MS) often develop symptoms including muscle weakness, spasticity, imbalance, and sensory loss in the lower limbs, especially at the ankle, which result in impaired balance and locomotion and increased risk of falls. Rehabilitation strategies that improve ankle function may imp...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.12.006

    authors： Lee Y,Chen K,Ren Y,Son J,Cohen BA,Sliwa JA,Zhang LQ

    更新日期：2017-01-01 00:00:00

  • Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools.

    abstract：:Multiple sclerosis (MS) is a complex chronic immune disease in the central nervous system, causing neurological disability among young and middle-aged adults. Impaired cognition is now emerging as a major clinical symptom being present in more than 50% of MS patients. Recent data support that neuroinflammation mediate...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2020.102622

    authors： Barros C,Fernandes A

    更新日期：2020-11-14 00:00:00

  • Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review.

    abstract：INTRODUCTION:Natalizumab break exposes multiple sclerosis (MS) patients to a high risk of disease reactivation or rebound, whose prevention and treatment constitute a clinical challenge. CASE PRESENTATION:We describe a dramatic case of MS rebound, characterized by the development of severe neurological and psychiatric...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2019.03.002

    authors： Federle L,Puthenparampil M,Stenta G,Paolo G,Francesco P

    更新日期：2019-05-01 00:00:00

  • Pain-related illness intrusiveness is associated with lower activity engagement among persons with multiple sclerosis.

    abstract：BACKGROUND:Pain can interfere with the daily functioning of persons with multiple sclerosis (PwMS). Furthermore, beliefs about pain and activity engagement are reliably associated with persons' experience of chronic pain. This study aimed to explore the extent to which different aspects of PwMS' activity engagement is ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.101882

    authors： Gromisch ES,Kerns RD,Beauvais J

    更新日期：2020-02-01 00:00:00

  • Under-treated depression negatively impacts lifestyle behaviors, participation and health-related quality of life among older people with multiple sclerosis.

    abstract：PURPOSE:To what extent depression may negatively impact successful aging with multiple sclerosis (MS) is not known. We examined the impact of depression/depressive symptoms on lifestyle choices (diet, exercise, smoking and alcohol), participation and health-related quality of life (HRQoL) among older people living with...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.msard.2019.101919

    authors： Ploughman M,Wallack EM,Chatterjee T,Kirkland MC,Curtis ME,Health Lifestyle and Aging with MS Consortium.

    更新日期：2020-05-01 00:00:00

  • A review of the ethics of the use of placebo in clinical trials for relapsing-remitting multiple sclerosis therapeutics.

    abstract：:Randomized placebo-controlled clinical trials have been considered the most rigorous method of evaluating the efficacy of novel treatment interventions. The first effective disease-modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) were approved in the 1990s after a number of pivotal placebo-...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2016.03.019

    authors： Solomon AJ,Bernat JL

    更新日期：2016-05-01 00:00:00

  • Update on the cardiovascular profile of fingolimod in the therapy of relapsing-remitting multiple sclerosis (MS).

    abstract：BACKGROUND:Fingolimod (FTY720) has been approved as the first oral representative of the class of sphingosine-1-phosphate (S1P) receptor modulators for the treatment of relapsing-remitting multiple sclerosis (MS). Besides inducing vaso-relaxation, fingolimod can also influence electrical conduction in the myocardium an...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2016.04.002

    authors： Meissner A,Limmroth V

    更新日期：2016-07-01 00:00:00

  • Treating acute ischemic stroke in a patient with multiple sclerosis: A challenging issue.

    abstract：:Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination and neurodegeneration in the central nervous system. Recent studies suggested that patients with MS might have a greater risk of ischaemic stroke (IS). IS treatment with intravenous alteplase (IVA) in MS has rarely been reported....

    journal_title：Multiple sclerosis and related disorders

    pub_type：

    doi：10.1016/j.msard.2020.101962

    authors： de Falco A,De Simone M,d'Onofrio F,Spitaleri D,de Falco FA

    更新日期：2020-05-01 00:00:00

  • Capillary leak syndrome in neuromyelitis optica treated with rituximab.

    abstract：:61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. W...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.06.001

    authors： Fuentes Fernandez I,Hernandez-Clares R,Carreón Guarnizo E,Meca Lallana JE

    更新日期：2017-08-01 00:00:00

  • Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

    abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.msard.2018.12.011

    authors： Mealy MA,Mossburg SE,Kim SH,Messina S,Borisow N,Lopez-Gonzalez R,Ospina JP,Scheel M,Yeshokumar AK,Awad A,Leite MI,Arango JJ,Paul F,Palace J,Kim HJ,Levy M

    更新日期：2019-02-01 00:00:00

  • An extremely aggressive case of Marburg's disease treated with high dose cyclophosphamide. A case report.

    abstract：BACKGROUND:The acute, fulminant type of Multiple Sclerosis (MS), known as Marburg Disease, has been shown to have poor response to conventional acute treatments typically used for demyelinating diseases. METHODS:We report a 20 y/o postpartum female who was consulted to the Neurology service given findings of subacute ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.03.014

    authors： Avila-Ornelas J,Labat E,Alfonso G,Serrano C,Fiorito F

    更新日期：2019-06-01 00:00:00

  • Spatio-temporal gait parameters change differently according to speed instructions and walking history in MS patients with different ambulatory dysfunction.

    abstract：BACKGROUND:Different walking capacity test formats are applied, but their impact on the gait pattern in persons with MS (pwMS) has not yet been investigated according to baseline velocity performance. OBJECTIVE:To assess, in pwMS with different ambulation dysfunction, the impact of speed instructions and previous walk...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2013.01.004

    authors： Feys P,Severijns D,Vantenderloo S,Knuts K,Hannes D,Gijbels D,Wens I

    更新日期：2013-07-01 00:00:00

  • The 20-year history: Change of multiple sclerosis patient profile over 20 years.

    abstract：BACKGROUND:Patients attending multiple sclerosis (MS) clinics experience less disability compared to previous years. OBJECTIVE:This study was conducted retrospectively examining the patient records of our MS Clinic. The patient records in 1996 were compared to those in 2016. METHODS:Demographic data, duration of dise...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.05.002

    authors： Ozakbas S,Cinar BP,Kahraman T,Multiple Sclerosis Research Group.

    更新日期：2019-08-01 00:00:00

  • Fatigue, depression, and physical activity in relapsing-remitting multiple sclerosis: Results from a prospective, 18-month study.

    abstract：BACKGROUND:Fatigue, depression, and physical inactivity are common in multiple sclerosis (MS), but there is limited information on the bi-directional associations among those variables over a long period of time. OBJECTIVE:This study examined the hypothesis that fatigue and depression would predict change in physical ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2011.08.003

    authors： Motl RW,Suh Y,Weikert M,Dlugonski D,Balantrapu S,Sandroff B

    更新日期：2012-01-01 00:00:00

  • Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support.

    abstract：BACKGROUND:Social support has been identified as a buffering or intervening variable in stressful life events. Research has demonstrated that greater social support is associated with better mental health in multiple sclerosis (MS), but little is known about its links to specific aspects of mental health. We therefore ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.09.039

    authors： Henry A,Tourbah A,Camus G,Deschamps R,Mailhan L,Castex C,Gout O,Montreuil M

    更新日期：2019-01-01 00:00:00

  • The long-term impact of multiple sclerosis on the risk of divorce.

    abstract：BACKGROUND:Several studies have investigated the impact of multiple sclerosis (MS) on the risk of divorce. However, current evidence is inconclusive and limited by e.g. small sample populations, short follow-up, and/or lack of a control group. The objective of this retrospective, observational study was to estimate the...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.07.002

    authors： Landfeldt E,Castelo-Branco A,Svedbom A,Löfroth E,Kavaliunas A,Hillert J

    更新日期：2018-08-01 00:00:00

  • Lack of magnetic resonance imaging lesion activity as a treatment target in multiple sclerosis: An evaluation using electronically collected outcomes.

    abstract：BACKGROUND:The appropriate treatment target in multiple sclerosis (MS) is unclear. Lack of magnetic resonance imaging (MRI) lesion activity, a component of the no evidence of disease activity concept, has been proposed as a treatment target in MS. We used our MS database to investigate whether aggressively pursuing MRI...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.07.017

    authors： Conway DS,Thompson NR,Cohen JA

    更新日期：2016-09-01 00:00:00

  • Unmet needs of multiple sclerosis patients in the community.

    abstract：BACKGROUND:There is no evidence that disease modifying therapies (DMTs) are beneficial in progressive (non-relapsing) MS. However, these patients may benefit from multidiscipliniary interventions, and require financial and community support. Non-pharmacological needs of MS patients may be overlooked during fund allocat...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.msard.2015.01.003

    authors： Lonergan R,Kinsella K,Fitzpatrick P,Duggan M,Jordan S,Bradley D,Hutchinson M,Tubridy N

    更新日期：2015-03-01 00:00:00

  • MSer - A new, neutral descriptor for someone with multiple sclerosis.

    abstract：:Lay-members of the public are often involved in grant and ethics review panels. Furthermore grant applications/reports all require some form of lay summary. In response to critical remarks from people with multiple sclerosis (MS) about using the term 'sufferer' as a descriptor, a series of surveys using the internet/s...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2013.06.010

    authors： Baker D,Pepper G,Yauner F,Giovannoni G

    更新日期：2014-01-01 00:00:00

  • Coexistent MOG, NMDAR, CASPR2 antibody positivity: Triumph over the triumvirate.

    abstract：:Myelin oligodendrocyte glycoprotein (MOG) antibody (MOG -Ab) positive cases can have a focal encephalitis like presentation. Many reports of anti N-methyl-D-aspartate receptor (NMDAR) encephalitis have documented simultaneous coexistence of MOG-Ab which is explained by the coexpression of NMDA receptors and MOG on oli...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 信件

    doi：10.1016/j.msard.2020.102468

    authors： Cherian A,Divya KP,Shetty SC,Kannoth S,Thomas B

    更新日期：2020-11-01 00:00:00

  • Cognitive and neuropsychiatric disorders among multiple sclerosis patients from Latin America: Results of the RELACCEM study.

    abstract：BACKGROUND:Cognitive impairment and psychiatric symptoms impact many aspects of the lives of people with multiple sclerosis [MS]. This literature is based largely on North American and Western European samples, and little is known about these aspects of MS disability in Latin America. OBJECTIVE:RELACCEM is a longitudi...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2013.10.007

    authors： Caceres F,Vanotti S,Benedict RH,RELACCEM Work Group.

    更新日期：2014-05-01 00:00:00

  • 2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

    abstract：BACKGROUND:McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. OBJECTIVE:Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). METHODS:We retrospectively identified pat...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.008

    authors： Gobbin F,Zanoni M,Marangi A,Orlandi R,Crestani L,Benedetti MD,Gajofatto A

    更新日期：2019-04-01 00:00:00

  • Favorable outcome of interferon-beta associated thrombotic microangiopathy following treatment with corticosteroids, plasma exchange and rituximab: A case report.

    abstract：:Thrombotic microangiopathy (TMA) is a rare but increasingly recognized complication of interferon-beta therapy, which can be associated with serious sequelae. We report on a 53-year-old woman with a longstanding history of relapsing-remitting multiple sclerosis, who developed TMA after 15 years of high-dose treatment ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.09.002

    authors： Gerischer LM,Siebert E,Janke O,Jungehuelsing GJ,Ruprecht K

    更新日期：2016-11-01 00:00:00

  • Chronic lung disease and multiple sclerosis: Incidence, prevalence, and temporal trends.

    abstract：OBJECTIVES:We aimed to estimate the incidence and prevalence of chronic lung disease (CLD), including asthma and chronic obstructive pulmonary disease, in the MS population versus a matched cohort from the general population. METHODS:We used population-based administrative data from four Canadian provinces to identify...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.05.009

    authors： Marrie RA,Patten S,Tremlett H,Svenson LW,Wolfson C,Yu BN,Elliott L,Profetto-McGrath J,Warren S,Leung S,Jette N,Bhan V,Fisk JD

    更新日期：2016-07-01 00:00:00

  • Five year iron changes in relapsing-remitting multiple sclerosis deep gray matter compared to healthy controls.

    abstract：BACKGROUND:Relapsing-Remitting MS (RRMS) Deep Grey Matter (DGM) 5 year changes were examined using MRI measures of volume, transverse relaxation rate (R2*) and quantitative magnetic susceptibility (QS). By applying Discriminative Analysis of Regional Evolution (DARE), R2* and QS changes from iron and non-iron sources w...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.05.028

    authors： Elkady AM,Cobzas D,Sun H,Seres P,Blevins G,Wilman AH

    更新日期：2019-08-01 00:00:00

  • Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.

    abstract：OBJECTIVE:To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome. METHODOLOGY:Case series. RESULTS:We present two cases. Case 1 is an 18-year-old woman who presented with headache, blurred vision, and papilledema and was initially diagnosed with pseudotumor cerebri syndrome. CSF showed mil...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.10.003

    authors： Narayan RN,Wang C,Sguigna P,Husari K,Greenberg B

    更新日期：2019-01-01 00:00:00

  • The epidemiology of comorbidities among multiple sclerosis patients in northeastern Poland.

    abstract：BACKGROUND:To determine and compare comorbidity levels in the multiple sclerosis (MS) population in Poland using a matched cohort from the general population. METHODS:We compared our database (standardized medical histories and medical records) from a MS center at the Department of Neurology, Medical University of Bia...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102051

    authors： Kapica-Topczewska K,Tarasiuk J,Chorąży M,Czarnowska A,Brola W,Szczepański M,Kochanowicz J,Kułakowska A

    更新日期：2020-06-01 00:00:00

  • Peak width of skeletonized mean diffusivity (PSMD) as marker of widespread white matter tissue damage in multiple sclerosis.

    abstract：BACKGROUND:Peak width of skeletonized mean diffusivity (PSMD) is a novel and fully automated, MRI biomarker, which has shown clinical relevance in cerebral small vessel diseases (SVD). We aimed here to assess PSMD levels across the brain of patients with multiple sclerosis (MS), in comparison to normal controls (NC) an...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.11.011

    authors： Vinciguerra C,Giorgio A,Zhang J,Di Donato I,Stromillo ML,Tappa Brocci R,Federico A,Dotti MT,De Stefano N

    更新日期：2019-01-01 00:00:00