Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis.

Abstract:

BACKGROUND:The association between routine laboratory findings, including cerebrospinal fluid biomarkers, and neurological outcomes in patients with multiple sclerosis (MS) has not been fully elucidated. In this study, we evaluated blood and cerebrospinal fluid (CSF) analysis results at diagnosis and before treatment in patients with MS and assessed their correlations with neurological outcomes. MATERIALS AND METHODS:In this study, 38 consecutive patients with MS (36 with relapsing-remitting MS and 2 with primary progressive MS) were recruited. Before treatment, all patients underwent routine CSF analysis at the time of diagnosis, including evaluation of albumin and immunoglobulin G (IgG) levels. The association between laboratory data and neurological outcomes was comprehensively evaluated. Subsequent neurological outcome was assessed by using the Expanded Disability Status Scale (EDSS) score at 1 year and 5 years after diagnosis and relapse frequency in the first year and in the first 5 years. RESULTS:The IgG level in the CSF (rho = 0.46, p = 0.004), oligoclonal band count (rho = 0.61, p = 0.006), ratio of IgG and total protein in CSF (rho = 0.59, p < 0.0001), and ratio of IgG and albumin in CSF (rho = 0.67, p < 0.0001) showed moderate to strong correlations with the subsequent EDSS score 1 year after diagnosis. These variables still showed significant correlations with EDSS 5 years later. Albumin and lactate dehydrogenase levels in CSF did not correlate with the subsequent EDSS score. Relapse frequency did not correlate with any of the studied serum and CSF biomarkers. CONCLUSION:IgG levels in CSF at MS diagnosis are significantly correlated with the level of neurological disability independent of the relapse frequency. Markers of intrathecal IgG synthesis, such as the IgG index, are useful in estimating the present and subsequent clinical severity in patients with MS.

authors

Akaishi T,Takahashi T,Fujihara K,Misu T,Nishiyama S,Takai Y,Fujimori J,Abe M,Ishii T,Aoki M,Nakashima I

doi

10.1016/j.msard.2020.102382

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

102382

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(20)30457-0

journal_volume

45

pub_type

杂志文章
  • Do neutralising antibodies against exogenous interferon-beta inhibit endogenous signalling pathways?

    abstract:INTRODUCTION:Interferon-beta (IFNβ) is currently the most used disease-modifying treatment for relapsing-remitting multiple sclerosis (RRMS), but it can lead to the production of neutralising antibodies (NABs) against IFNβ. CLINICAL CASE:A lady with a past history of genital herpes was diagnosed with RRMS, started IFN...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2014.11.007

    authors: Fine D,Dattani A,Moreira I,Giovannoni G,Marta M

    更新日期:2015-01-01 00:00:00

  • Efficacy of computer-based cognitive training in neuropsychological performance of patients with multiple sclerosis: A systematic review and meta-analysis.

    abstract:IMPORTANCE:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by relapses and a progressive course that may lead to accumulation of physical and cognitive disability. Cognitive training interventions seem to improve the cognitive performance of MS patients. The aim of ...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.msard.2017.12.017

    authors: Dardiotis E,Nousia A,Siokas V,Tsouris Z,Andravizou A,Mentis AA,Florou D,Messinis L,Nasios G

    更新日期:2018-02-01 00:00:00

  • Lack of magnetic resonance imaging lesion activity as a treatment target in multiple sclerosis: An evaluation using electronically collected outcomes.

    abstract:BACKGROUND:The appropriate treatment target in multiple sclerosis (MS) is unclear. Lack of magnetic resonance imaging (MRI) lesion activity, a component of the no evidence of disease activity concept, has been proposed as a treatment target in MS. We used our MS database to investigate whether aggressively pursuing MRI...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2016.07.017

    authors: Conway DS,Thompson NR,Cohen JA

    更新日期:2016-09-01 00:00:00

  • Could Sars-Cov2 affect MS progression?

    abstract::A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2. These two mechanisms may cause a worsening of MS several months after the resolution of the infection. ...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.msard.2020.102540

    authors: Di Stadio A,Romani L,Bernitsas E

    更新日期:2020-11-01 00:00:00

  • Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of Multiple Sclerosis.

    abstract:BACKGROUND:Fatigue is a complex and disabling symptom of Multiple Sclerosis (MS); however, there is conflicting evidence of the relationship between fatigue and clinical features of MS. Furthermore, few studies have considered these relationships specifically in a progressive MS population. AIMS:(1) estimate the preva...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.01.011

    authors: Rooney S,Wood L,Moffat F,Paul L

    更新日期:2019-02-01 00:00:00

  • FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) unmasked by withdrawal of immunosuppression for Crohn's disease?

    abstract::A 31-year-old pregnant woman presented with headache, fever and left-sided focal motor seizures, which progressed to bilateral tonic-clonic seizures. Her medical history included Crohn's disease treated with azathioprine and adalimumab, which were discontinued when she became pregnant. Her cerebro-spinal fluid was ent...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 信件

    doi:10.1016/j.msard.2020.102729

    authors: Stamenova S,Redha I,Schmierer K,Garcia ME

    更新日期:2020-12-31 00:00:00

  • Capillary leak syndrome in neuromyelitis optica treated with rituximab.

    abstract::61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. W...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2017.06.001

    authors: Fuentes Fernandez I,Hernandez-Clares R,Carreón Guarnizo E,Meca Lallana JE

    更新日期:2017-08-01 00:00:00

  • Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis.

    abstract:BACKGROUND:Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. OBJECTIVE:Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina s...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2016.10.009

    authors: Longbrake EE,Lancia S,Tutlam N,Trinkaus K,Naismith RT

    更新日期:2016-11-01 00:00:00

  • A case of dextrocardia following maternal exposure to generic Fingolimod during the first trimester of pregnancy.

    abstract::Fingolimod, taken orally once per day, is approved for the treatment of relapsing-remitting multiple sclerosis (MS). It should be stopped at least two months before conception as it is not considered safe during pregnancy or when breast feeding. In vitro and animal studies have found a possibly increased risk of conge...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2018.02.015

    authors: Navardi S,Sahraian MA

    更新日期:2018-04-01 00:00:00

  • Brief international cognitive assessment for multiple sclerosis (BICAMS): A danish validation study of sensitivity in early stages of MS.

    abstract:BACKGROUND:Cognitive impairment is highly prevalent in multiple sclerosis (MS). Due to the lack of specialized neuropsychological resources in many MS clinics, a brief cognitive monitoring tool that can be administered by other MS clinic staff is needed. BICAMS (Brief International Cognitive As-sessment for Multiple Sc...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.101458

    authors: Marstrand L,Østerberg O,Walsted T,Skov AC,Schreiber KI,Sellebjerg F

    更新日期:2020-01-01 00:00:00

  • Relative importance of vision and proprioception in maintaining standing balance in people with multiple sclerosis.

    abstract:BACKGROUND:Balance impairment is common and a risk factor of falls in people with multiple sclerosis (MS). The purpose of this study was to evaluate the relative importance between vision and proprioception in maintaining standing body balance among individuals with MS compared with healthy individuals. METHODS:Thirty...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.101901

    authors: Yang F,Liu X

    更新日期:2019-12-20 00:00:00

  • 2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

    abstract:BACKGROUND:McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. OBJECTIVE:Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). METHODS:We retrospectively identified pat...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.01.008

    authors: Gobbin F,Zanoni M,Marangi A,Orlandi R,Crestani L,Benedetti MD,Gajofatto A

    更新日期:2019-04-01 00:00:00

  • Factors associated with adherence to disease modifying therapy in multiple sclerosis: An observational survey from a referral center in Lithuania.

    abstract:AIM OF THE STUDY:To investigate adherence to disease modifying therapy (DMT) in Lithuanian population of multiple sclerosis patients and factors associated to it. METHODS:Patients receiving one of the following DMT's: Interferon β 1a (Rebif) 44 micrograms three times a week subdermally (s/c) or Interferon β 1a (Avonex...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2017.02.016

    authors: Duchovskiene N,Mickeviciene D,Jurkeviciene G,Dirziuviene B,Balnyte R

    更新日期:2017-04-01 00:00:00

  • Cognitive and neuropsychiatric disorders among multiple sclerosis patients from Latin America: Results of the RELACCEM study.

    abstract:BACKGROUND:Cognitive impairment and psychiatric symptoms impact many aspects of the lives of people with multiple sclerosis [MS]. This literature is based largely on North American and Western European samples, and little is known about these aspects of MS disability in Latin America. OBJECTIVE:RELACCEM is a longitudi...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2013.10.007

    authors: Caceres F,Vanotti S,Benedict RH,RELACCEM Work Group.

    更新日期:2014-05-01 00:00:00

  • Mesenchymal stem cells in experimental autoimmune encephalomyelitis model of multiple sclerosis: A systematic review and meta-analysis.

    abstract:BACKGROUND/AIMS:Mesenchymal stem cells (MSCs) transplantation has been considered a possible therapeutic method for Multiple Sclerosis (MS). However, no quantitative data synthesis of MSCs therapy for MS exists. We conducted a systematic review and meta-analysis to evaluate the effects of MSCs in experimental autoimmun...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.msard.2020.102200

    authors: Yanwu Y,Meiling G,Yunxia Z,Qiukui H,Birong D

    更新日期:2020-09-01 00:00:00

  • Natalizumab is effective in controlling the inflammatory rebound after its discontinuation and failure of an alternative treatment.

    abstract::Progressive multifocal leukoencephalopathy (PML) is the most feared complication when natalizumab (NAT) is used in the treatment of relapsing multiple sclerosis (MS). JC virus serologic status is a currently established risk factor for PML. When seroconversion occurs, NAT discontinuation should be based on a solid rat...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2015.04.005

    authors: Barroso B,Miquel M,Marasescu R,Demasles S,Krim E,Bonnan M

    更新日期:2015-07-01 00:00:00

  • Evaluating the efficacy and safety of ZytuxTM (Rituximab, AryoGen pharmed) in Iranian multiple sclerosis patients: An observational study.

    abstract:BACKGROUND:Anti-CD20 monoclonal antibodies such as ocrelizumab, rituximab, and ofatumumab target B-cell lineage. Clinical trials have demonstrated their effect on reducing both magnetic resonance imaging (MRI) active lesion burden as well as clinical activity. Zytux™ (Rituximab, AryoGen Pharmed) used in the present stu...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.101419

    authors: Naser Moghadasi A,Darki A,Masoumi P,Hashemi SN,Ghadiri F

    更新日期:2019-11-01 00:00:00

  • Management of infusion related reactions associated with alemtuzumab in patients with multiple sclerosis.

    abstract:OBJECTIVE:Infusion-associated reactions (IARs) occur in >90% patients with multiple sclerosis (MS) treated with alemtuzumab. We aimed to study the frequency of IARs at 2 sites using 5 days of steroids (1g/day of IV methylprednisolone), but otherwise distinct protocols. METHODS:This was retrospective chart review of 38...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.msard.2017.07.019

    authors: Šega-Jazbec S,Barun B,Horvat Ledinek A,Fabekovac V,Krbot Skorić M,Habek M

    更新日期:2017-10-01 00:00:00

  • Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions.

    abstract:BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS) that preferentially targets the spinal cord and optic nerves. Increasing disability is accrued with each inflammatory attack. Disability has been shown to be an independent predictor of poor quality of...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.msard.2018.12.011

    authors: Mealy MA,Mossburg SE,Kim SH,Messina S,Borisow N,Lopez-Gonzalez R,Ospina JP,Scheel M,Yeshokumar AK,Awad A,Leite MI,Arango JJ,Paul F,Palace J,Kim HJ,Levy M

    更新日期:2019-02-01 00:00:00

  • Five year iron changes in relapsing-remitting multiple sclerosis deep gray matter compared to healthy controls.

    abstract:BACKGROUND:Relapsing-Remitting MS (RRMS) Deep Grey Matter (DGM) 5 year changes were examined using MRI measures of volume, transverse relaxation rate (R2*) and quantitative magnetic susceptibility (QS). By applying Discriminative Analysis of Regional Evolution (DARE), R2* and QS changes from iron and non-iron sources w...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.05.028

    authors: Elkady AM,Cobzas D,Sun H,Seres P,Blevins G,Wilman AH

    更新日期:2019-08-01 00:00:00

  • A case of Takotsubo syndrome during a multiple sclerosis brainstem relapse.

    abstract:BACKGROUND:We report a case of a woman affected by relapsing remitting Multiple Sclerosis who developed acute left ventricular dysfunction in the context of a severe brainstem relapse, one month after an attempt of in-vitro fertilization. DISCUSSION:The characteristics of our case are consistent with the hypothesis of...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2018.05.005

    authors: Prestipino E,Squitieri M,Razzolini L,Pastò L,Forleo P,Amato MP

    更新日期:2018-08-01 00:00:00

  • Treating acute ischemic stroke in a patient with multiple sclerosis: A challenging issue.

    abstract::Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination and neurodegeneration in the central nervous system. Recent studies suggested that patients with MS might have a greater risk of ischaemic stroke (IS). IS treatment with intravenous alteplase (IVA) in MS has rarely been reported....

    journal_title:Multiple sclerosis and related disorders

    pub_type:

    doi:10.1016/j.msard.2020.101962

    authors: de Falco A,De Simone M,d'Onofrio F,Spitaleri D,de Falco FA

    更新日期:2020-05-01 00:00:00

  • Photophobia in multiple sclerosis.

    abstract:BACKGROUND:Photophobia has never been investigated in MS. METHODS:In this pilot study we used photosensitivity questionnaire assessment (PAQ) to evaluate tolerability to light in 73 MS patients and 62 healthy controls. RESULTS:We identified a lower PAQ score and a higher number of photophobic subjects in MS than in c...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2018.09.005

    authors: Cortese A,Conte A,Ferrazzano G,Sgarlata E,Millefiorini E,Frontoni M,Berardelli A

    更新日期:2018-11-01 00:00:00

  • Evolution of multiple sclerosis prevalence and phenotype in Latin America.

    abstract:BACKGROUND:Literature regarding MS epidemiology and phenotype is scarce but has increased markedly over the past years. The objective of the present work is to assess the evolution of the prevalence and phenotype of MS in Latin America during recent years. METHODS:Review of literature. RESULTS:MS prevalence levels ar...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.msard.2018.03.014

    authors: Negrotto L,Correale J

    更新日期:2018-05-01 00:00:00

  • Under-treated depression negatively impacts lifestyle behaviors, participation and health-related quality of life among older people with multiple sclerosis.

    abstract:PURPOSE:To what extent depression may negatively impact successful aging with multiple sclerosis (MS) is not known. We examined the impact of depression/depressive symptoms on lifestyle choices (diet, exercise, smoking and alcohol), participation and health-related quality of life (HRQoL) among older people living with...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.msard.2019.101919

    authors: Ploughman M,Wallack EM,Chatterjee T,Kirkland MC,Curtis ME,Health Lifestyle and Aging with MS Consortium.

    更新日期:2020-05-01 00:00:00

  • The epidemiology of comorbidities among multiple sclerosis patients in northeastern Poland.

    abstract:BACKGROUND:To determine and compare comorbidity levels in the multiple sclerosis (MS) population in Poland using a matched cohort from the general population. METHODS:We compared our database (standardized medical histories and medical records) from a MS center at the Department of Neurology, Medical University of Bia...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2020.102051

    authors: Kapica-Topczewska K,Tarasiuk J,Chorąży M,Czarnowska A,Brola W,Szczepański M,Kochanowicz J,Kułakowska A

    更新日期:2020-06-01 00:00:00

  • PER3 VNTR polymorphism in Multiple Sclerosis: A new insight to impact of sleep disturbances in MS.

    abstract:BACKGROUND:Multiple Sclerosis (MS) is a degenerative disease of central nervous system caused by an immune response against the myelin. About half of MS patients suffers from sleep disturbances. The circadian clock genes such as PER3 controls circadian rhythm and sleep. Due to the role of PER3 in sleep disturbances and...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2017.07.005

    authors: Golalipour M,Maleki Z,Farazmandfar T,Shahbazi M

    更新日期:2017-10-01 00:00:00

  • Tonsillectomy in multiple sclerosis patients: Retrospective, case-controlled, exploratory study.

    abstract:BACKGROUND:Previous studies have shown an effect of tonsillectomy and greater risk for future autoimmune diseases. Currently there are only few outdated analyses of tonsillectomy and multiple sclerosis (MS) risk. OBJECTIVE:To investigate the prevalence of tonsillectomy in MS patients and healthy controls (HCs). METHO...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2020.102131

    authors: Jakimovski D,Ahmed MK,Vaughn CB,Zivadinov R,Weinstock-Guttman B

    更新日期:2020-07-01 00:00:00

  • Temporal evolution of acute multiple sclerosis lesions on serial sodium (23Na) MRI.

    abstract:BACKGROUND:Several studies have reported the characteristics of acute multiple sclerosis (MS) lesions on diffusion-weighted magnetic resonance imaging (DWI MRI). Current publications reported a transient reduction of the apparent diffusion coefficient (ADC) delineating an early phase of lesion evolution, before increas...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2019.01.027

    authors: Eisele P,Konstandin S,Szabo K,Ebert A,Roßmanith C,Paschke N,Kerschensteiner M,Platten M,Schoenberg SO,Schad LR,Gass A

    更新日期:2019-04-01 00:00:00

  • Clinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).

    abstract:BACKGROUND:The 2015 criteria for diagnosing neuromyelitis optica spectrum disorder (NMOSD) have encouraged several groups across the world to report on their patients using these criteria. The disease typically manifests with severe relapses of optic neuritis, longitudinally extensive myelitis and/or brainstem syndrome...

    journal_title:Multiple sclerosis and related disorders

    pub_type: 杂志文章

    doi:10.1016/j.msard.2018.11.031

    authors: Fragoso YD,Sousa NAC,Alves-Leon SV,Dias RM,Pimentel MLV,Gomes S,Goncalves MVM,Stella CV,Tauil CB,Anacleto A,Spessotto CV,Correa EC,Eboni ACB,Damasceno A,Damasceno B,Farinhas JGD,Mota RSS,Nogueira EGA,Pereira VCSR,Sc

    更新日期:2019-01-01 00:00:00