Associations of IL-2 and IL-4 Expression and Polymorphisms With the Risks of Mycoplasma pneumoniae Infection and Asthma in Children.


INTRODUCTION:Asthma is an inflammatory disorder of the airways and the symptoms of asthma could be exacerbated by Mycoplasma pneumoniae infection. Interleukin-2 and interleukin-4 have been implicated in immune and inflammatory reactions. We examined the associations of IL2 and IL4 polymorphisms and expression with the risks of asthma and M. pneumoniae infection in children. METHODS:392 asthmatic children and 849 controls were recruited into the study. Eight polymorphisms in IL2 and IL4 were genotyped with Sequenom MassARRAY platform. M. pneumoniae infection and copy number was determined with fluorescence PCR. IL-2 and IL-4 serum expression levels were determined by using ELISA. RESULTS:We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001). Besides, the association of other polymorphisms, except rs2070874 polymorphism, became apparent when the asthmatic children were grouped according to GINA classification of asthma control and severity. In addition, IL-2 and IL-4 serum expression levels were significantly higher in M. pneumoniae negative (P=.038) and positive (P=.011) subjects respectively. This observation holds true among asthmatic patients (P=.016 for IL-2 and P=.042 for IL-4), but only the IL-4 observation remained correct among non-asthmatic controls (P=.032). We also observed that the rs6534349 GG genotype was significantly associated with increased odds of getting high load M. pneumoniae infection (P=.0376). CONCLUSIONS:IL2 and IL4 could be important biomarkers for estimating the risks of asthma and M. pneumoniae infection in children.


Arch Bronconeumol


Wang RS,Jin HX,Shang SQ,Liu XY,Chen SJ,Jin ZB




Has Abstract


2015-11-01 00:00:00














  • Treatment of Adult Primary Alveolar Proteinosis.

    abstract::Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant is due to decreased clearance by the alveolar macrophages. Its p...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Rodríguez Portal JA

    更新日期:2015-07-01 00:00:00

  • Human papillomavirus in non-small-cell lung cancer: the impact of EGFR mutations and the response to erlotinib.

    abstract::It has been suggested that human papillomavirus (HPV) could participate in the development of non-small-cell lung cancer (NSCLC). A higher HPV infection rate has been reported in the NSCLC samples from Asian non-smoker patients, with adenocarcinomas or responders to EGFR tyrosine kinase inhibitors (EGFR-TKI). We explo...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Márquez-Medina D,Gasol-Cudós A,Taberner-Bonastre MT,Samamé Pérez-Vargas JC,Salud-Salvia A,Llombart-Cussac A

    更新日期:2013-02-01 00:00:00

  • [Interleukin 10 and tumor necrosis factor alpha gene expression in respiratory and peripheral muscles. Relation to sarcolemmal damage].

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) has been implicated in loss of muscle mass in chronic obstructive pulmonary disease and other consumptive processes. TNF-alpha production would be related to inflammation arising from pulmonary disease itself or, alternatively, from smoking, and would be carried to the...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Palacio J,Gáldiz JB,Bech JJ,Mariñán M,Casadevall C,Martínez P,Gea J

    更新日期:2002-07-01 00:00:00

  • Diagnosis of Tuberculous Infection in Immunosuppressed Patients and/or Candidates for Biologics Using a Combination of 2 IGRA Tests: T-SPOT.TB/QuantiFERON TB Gold In-Tube vs. T-SPOT.TB/QuantiFERON TB Gold Plus.

    abstract:INTRODUCTION:The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold (In-Tube/Plus) with those of T-SPOT.TB, and to analyse the effectivene...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Fernández-Blázquez A,Argüelles Menéndez P,Sabater-Cabrera C,García-García JM,Asensi Álvarez V,Palacios Gutiérrez JJ,en representación de la Red de Laboratorios de Microbiología del SESPA.

    更新日期:2020-06-10 00:00:00

  • Respiratory and Peripheral Muscle Assessment in the Intensive Care Unit.

    abstract::Atrophy and weakness of the respiratory and peripheral muscles is a common problem in the intensive care unit (ICU). It is difficult to diagnose, particularly in the early stages of critical disease. Consequently, many cases are detected only in advanced stages, for example, when difficulties in mechanical ventilation...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Carámbula A,Visca A,D'Amico S,Angulo M

    更新日期:2019-05-01 00:00:00

  • [Obtaining samples of the human diaphragm during upper laparotomy. A structural analysis].

    abstract:UNLABELLED:The diaphragm seems to undergo adaptive structural change in chronic obstructive pulmonary disease. The possibility of obtaining muscle specimens is limited, however, particularly when respiratory function is severely affected. OBJECTIVE:To assess the viability of a new technique for obtaining diaphragm mus...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Pastó M,Minguella J,Orozco-Levi M,Palacio J,Félez M,Broquetas J,Gea J

    更新日期:2000-01-01 00:00:00

  • [European Asthma Study. Identifying and treating young adults with epidemiological criteria for asthma in five areas of Spain. Spanish Group of the European Asthma Study].

    abstract:BACKGROUND AND OBJECTIVES:Asthma's great impact on public health stems from its chronicity and to high prevalence among all age groups and both sexes. To estimate the appropriateness of treatment and management of asthma in Spain during the period of 1991 and 1992, we analyzed data from the European Community Respirato...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Martínez-Moratalla J,Almar E,Sunyer J,Ramos J,Pereira A,Payo F,Antó JM

    更新日期:1999-05-01 00:00:00

  • Characteristics of candidates for lung transplantation due to chronic obstructive pulmonary disease and alpha-1 antitrypsin deficiency emphysema.

    abstract:INTRODUCTION:COPD and emphysema due to alpha-1 antitrypsin deficiency (AATD) are the first and fourth indications for lung transplantation worldwide, respectively. Despite this, there is little information regarding the health status of these patients at the time of transplantation. METHODS:Patients who received a lun...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Giacoboni D,Barrecheguren M,Esquinas C,Rodríguez E,Berastegui C,López-Meseguer M,Monforte V,Bravo C,Pirina P,Miravitlles M,Román A

    更新日期:2015-08-01 00:00:00

  • [Drainage of loculated and/or multiloculated pleural effusions using a small caliber catheter and urokinase (pleuro-fibrinolysis)].

    abstract::The main causes of pleural fluid drainage failure are known to be the formation of fibrin septa, increased viscosity in pleural fluid and inappropriate placement of chest tubes. Reports also tell us that such problems can be solved by using ultrasound as a guide for tube placement and by infusing intrapleural fibrinol...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: de Gregorio MA,Ruiz C,Alfonso ER,Fernández JA,Pérez-Trullén A,Ariño I,Rodríguez Panadero F

    更新日期:1996-12-01 00:00:00

  • [Diseases of the diaphragm].

    abstract::The diaphragm is the main muscle involved in ventilation and is supplied exclusively by the phrenic nerves. Congenital defects of the diaphragm muscle or phrenic nerve injury cause diaphragmatic paralysis-eventration. Prognosis and treatment depend on whether involvement is unilateral or bilateral and on the patient's...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: León-Atance P,Martínez-Hernández NJ,Milla-Saba AM,Roca-Fernández J

    更新日期:2011-01-01 00:00:00

  • [Diffuse interstitial lung disease related to peribronchiolar metaplasia].

    abstract::Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Cano-Jiménez E,Molina-Molina M,Ramírez J,Sánchez M,Aliaga JL,Xaubet A

    更新日期:2009-01-01 00:00:00

  • [Origin and development of RUTI, a new therapeutic vaccine against Mycobacterium tuberculosis infection].

    abstract::This article reviews the pathophysiology of the latent form of Mycobacterium tuberculosis along with its natural history and progression in infected tissues. The proposed hypotheses regarding the relationship between M tuberculosis and the associated immune response, the cause of granuloma necrosis, the tolerance of a...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Cardona PJ,Amat I

    更新日期:2006-01-01 00:00:00

  • IgG4-Related Lung Disease - Three Untreated Cases with a Benign Outcome.

    abstract::IgG4-related disease is a fibroinflammatory disease in which the organs involved share similar pathological findings. Chest disease has been recently clinically and radiologically characterized. Most reports advocate prompt immunosuppressive therapy and describe a fast and good response. We report 3 cases of untreated...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Baltaxe E,Shulimzon T,Lieberman S,Rozenman J,Perelman M,Segel MJ

    更新日期:2016-01-01 00:00:00

  • [Usefulness of a lung cancer rapid diagnosis specialist clinic. Contribution of ultrasound bronchoscopy].

    abstract:OBJECTIVE:To analyse the results obtained in the diagnosis and staging of lung cancer (LC) by a Lung Cancer Rapid Diagnosis Unit (LC-RDU) in which real-time endobronchial ultrasound-guided transbronchial needle aspiration (RT-EBUS guided-TBNA) is performed as part of the clinical evaluation of the patient prior to trea...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Sanz-Santos J,Andreo F,Sánchez D,Castellá E,Llatjós M,Bechini J,Guasch I,López De Castro P,Roca J,Parra I,Monsó E

    更新日期:2010-12-01 00:00:00

  • [Detection of lymph node involvement and surgical treatment of pulmonary neoplastic processes. Current state of diagnostic and therapeutic procedures].

    abstract::An analysis is made of different publications associated with the surgical staging and treatment of primary and metastasic pulmonary neoplastic processes. A suitable treatment program is essential to determine lymph node involvement in patients with bronchogenic carcinoma. The indication and sequence of the procedure ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: García-Yuste M,Matilla JM,González-Aragoneses F,Heras F

    更新日期:2010-03-01 00:00:00

  • [Usefulness of chest sonography in a respiratory medicine unit].

    abstract::Chest ultrasound, a diagnostic technique used mainly by radiologists, is useful for managing pleural effusion. Sonography and computed tomography (CT) are complementary, although the former is more accessible to clinicians because it is safe and easy to use and because results are available quickly. We evaluated the u...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Hidalgo Ramírez M,Cases Viedma E,Sanchis Aldás JL

    更新日期:2003-06-01 00:00:00

  • [Impact of exacerbations and admissions in chronic obstructive pulmonary disease].

    abstract::During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous stu...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Arnedillo Muñoz A

    更新日期:2010-01-01 00:00:00

  • P4 medicine: the future around the corner.

    abstract::Traditional medical practice has been "reactive" (doctor takes part when disease appears). The theoretical (scale free networks and complex systems), technological (high efficiency "omic" technologies) and conceptual (biology systems) advances throughout the last decade, allow us to anticipate the transition to an "an...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Sobradillo P,Pozo F,Agustí A

    更新日期:2011-01-01 00:00:00

  • [The evaluation of lung vascular compliance by the dobutamine stress test in patients who are candidates for extensive lung resections].

    abstract::This prospective descriptive study evaluated the utility of dobutamine in studying pulmonary vascular compliance in patients with lung neoplasms who are high risk candidates for lung resection. Seventeen consecutive patients meeting one of the following inclusion criteria were enrolled: FEV1 < 60% of theoretical value...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Rubia MV,Gandía F,Duque JL

    更新日期:1997-05-01 00:00:00

  • [Video-assisted thoracoscopic surgery in the treatment of pneumothorax: 107 consecutive procedures].

    abstract::The aim of this prospective study was to evaluate video-assisted thoracoscopic surgery (VATS) in primary and secondary spontaneous pneumothoraces. Over a 37-month period, 107 videothoracoscopic interventions were performed to treat spontaneous pneumothorax in 105 patients, 78 men and 27 women, whose average age was 28...

    journal_title:Archivos de bronconeumologia

    pub_type: 临床试验,杂志文章


    authors: Galbis Caravajal JM,Mafé Madueño JJ,Benlloch Carrión S,Baschwitz Gómez B,Rodríguez Paniagua JM

    更新日期:2003-07-01 00:00:00

  • [Pulmonary mucormycosis: a case report and review of the literature].

    abstract::Mucormycosis is an opportunistic mycotic infection, the frequency of pulmonary infection is 22% and the associated mortality rates were 83% for pulmonary. We present a case of pulmonary mucormycosis survived after the therapy with amphotericin B and surgery. ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Escobar Sacristán JA,de Granda Orive JI,Ramírez García JR,Ortiz de Villajos E,López Perales M,Barberán López J

    更新日期:1996-01-01 00:00:00

  • "Correct use of inhaled corticosteroids in chronic obstructive pulmonary disease": a consensus document.

    abstract:INTRODUCTION:Indications for inhaled corticosteroids (IC) in combination with long-acting bronchodilators (LABD) are well defined in clinical practice guidelines. However, there are some doubts about their efficacy and safety. The aim of this document is to establish an expert consensus to clarify these issues. METHOD...

    journal_title:Archivos de bronconeumologia

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Alcázar Navarrete B,Casanova C,Miravitlles M,de Lucas P,Riesco JA,Rodríguez González-Moro JM,Working Group “Consensus document on the appropriate use of inhaled corticosteroids in COPD”.

    更新日期:2015-04-01 00:00:00

  • [Variability among pathologists in the histological diagnosis of diffuse interstitial lung diseases].

    abstract:OBJECTIVE:Diffuse interstitial lung diseases (DILD) form a group of diseases which affect the alveolar interstitial space and share very similar clinical, radiological, and functional features, making lung biopsy essential for establishing diagnosis, prognosis, and treatment in many cases. We aimed to see whether there...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Sánchez-Varilla JM,Recio-Gallardo S,Benítez-Moya JM,Almadana-Pacheco V,Peña de Bustillo J,Martínez-Puentes V

    更新日期:2005-10-01 00:00:00

  • Differences in clinical features of two immigrant populations with tuberculosis.

    abstract::A study was performed to assess differences in the clinical presentation of tuberculosis between two groups of immigrants. Ninety-four patients seen in the emergency room for newly diagnosed tuberculosis between 2006 and 2012 were included. Forty-nine patients were from Asian countries and 45 from Latin America. Mean ...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Supervía A,Pallàs O,Piccari L,Herrera Fernández S,Domínguez Álvarez M,Cirera I,del Baño F

    更新日期:2015-06-01 00:00:00

  • [Sleep disorders in patients on a kidney transplant waiting list].

    abstract:OBJECTIVE:To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group. PATIENTS AND METHODS:We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age, sex, and body mass index (...

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    pub_type: 杂志文章


    authors: Jurado Gámez B,Martín-Malo A,Fernández Marín MC,Rodríguez-Benot A,Pascual N,Muñoz Cabrera L,Aljama P

    更新日期:2008-07-01 00:00:00

  • Results of a Diagnostic Procedure Based on Multiplex Technology on Dried Blood Spots and Buccal Swabs for Subjects With Suspected Alpha1 Antitrypsin Deficiency.

    abstract:INTRODUCTION:The objective of this analysis was the evaluation of a new national circuit used for diagnosing alpha1 antitrypsin deficiency (AATD) based on multiplex technology using online registration and mail posted samples from dried blood spots (DBS) and buccal swabs. METHODS:This is an observational, ongoing stud...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Lopez-Campos JL,Casas-Maldonado F,Torres-Duran M,Medina-Gonzálvez A,Rodriguez-Fidalgo ML,Carrascosa I,Calle M,Osaba L,Rapun N,Drobnic E,Miravitlles M

    更新日期:2021-01-01 00:00:00

  • [Sleep apnea-hypopnea syndrome in the elderly].

    abstract::The population pyramid is changing due to the increasing longevity of the population, making it a priority to have better knowledge of those diseases that have an increasingly major impact in advanced age. Sleep apnea-hypopnea syndrome (SAHS) affects 15-20% of individuals over 65 years. However, despite this high prev...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,评审


    authors: Martínez-García MA,Durán-Cantolla J,Montserrat JM

    更新日期:2010-09-01 00:00:00

  • [Treatment of chronic obstructive pulmonary disease in 5 Latin American cities: the PLATINO study].

    abstract:OBJECTIVE:PLATINO project is a population-based study designed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in São Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago de Chile, Chile; and Caracas, Venezuela. The objective of this portion of PLATINO was to describe preventive...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章,多中心研究


    authors: López Varela MV,Muiño A,Pérez Padilla R,Jardim JR,Tálamo C,Montes de Oca M,Valdivia G,Pertuzé J,Halbert R,Menezes AM,PLATINO Group.

    更新日期:2008-02-01 00:00:00

  • Manual Versus Digital Aspiration for First-Line Treatment of Primary Spontaneous Pneumothorax. The AMVADI Study: A Randomized Clinical Trial.

    abstract:INTRODUCTION:The effectiveness of needle aspiration in the initial treatment of primary spontaneous pneumothorax has been widely studied. The objective of this research was to compare digital with manual aspiration in a randomized clinical trial. METHODS:We designed a blinded parallel-group randomized clinical trial w...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Aguinagalde B,Zabaleta J,Fernández-Monge A,Lopez I,Izquierdo JM,Redin JA,López D,Emparanza JI

    更新日期:2020-10-01 00:00:00

  • [Analysis of respiratory muscle structure and tumor necrosis and insulin-like growth factor expression in chronic obstructive pulmonary disease: are samples valid if obtained during thoracotomy performed because of localized pulmonary neoplasia?].

    abstract:OBJECTIVE:Various methods have been used to obtain samples to study the structure of human respiratory muscles and the expression of diverse substances in them. Samples are most often obtained from autopsies, from muscle biopsies during thoracotomy performed because of a localized pulmonary lesion (TLL), and from ambul...

    journal_title:Archivos de bronconeumologia

    pub_type: 杂志文章


    authors: Casadevall C,Coronell C,Minguella J,Blanco L,Orozco-Levi M,Barreiro E,Broquetas J,Gea J

    更新日期:2004-05-01 00:00:00