Abstract:
INTRODUCTION:Asthma is an inflammatory disorder of the airways and the symptoms of asthma could be exacerbated by Mycoplasma pneumoniae infection. Interleukin-2 and interleukin-4 have been implicated in immune and inflammatory reactions. We examined the associations of IL2 and IL4 polymorphisms and expression with the risks of asthma and M. pneumoniae infection in children. METHODS:392 asthmatic children and 849 controls were recruited into the study. Eight polymorphisms in IL2 and IL4 were genotyped with Sequenom MassARRAY platform. M. pneumoniae infection and copy number was determined with fluorescence PCR. IL-2 and IL-4 serum expression levels were determined by using ELISA. RESULTS:We found a significant association of IL2 rs6534349 polymorphism with increased asthma risk (heterozygotes, P=.029; homozygous variants; P=.013) and of IL4 rs2227284 polymorphism with reduced asthma risk (heterozygotes, P=.026; homozygous variants; P=.001). Besides, the association of other polymorphisms, except rs2070874 polymorphism, became apparent when the asthmatic children were grouped according to GINA classification of asthma control and severity. In addition, IL-2 and IL-4 serum expression levels were significantly higher in M. pneumoniae negative (P=.038) and positive (P=.011) subjects respectively. This observation holds true among asthmatic patients (P=.016 for IL-2 and P=.042 for IL-4), but only the IL-4 observation remained correct among non-asthmatic controls (P=.032). We also observed that the rs6534349 GG genotype was significantly associated with increased odds of getting high load M. pneumoniae infection (P=.0376). CONCLUSIONS:IL2 and IL4 could be important biomarkers for estimating the risks of asthma and M. pneumoniae infection in children.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Wang RS,Jin HX,Shang SQ,Liu XY,Chen SJ,Jin ZBdoi
10.1016/j.arbres.2014.11.004subject
Has Abstractpub_date
2015-11-01 00:00:00pages
571-8issue
11eissn
0300-2896issn
1579-2129pii
S0300-2896(14)00442-6journal_volume
51pub_type
杂志文章abstract:OBJECTIVE:To compare the results of applying both the 1993 and 2002 guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) to identify respiratory events during nighttime polysomnography tests. PATIENTS AND METHODS:One hundred twenty consecutive patients with medium to high suspicion of sleep ap...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60331-5
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) has been implicated in loss of muscle mass in chronic obstructive pulmonary disease and other consumptive processes. TNF-alpha production would be related to inflammation arising from pulmonary disease itself or, alternatively, from smoking, and would be carried to the...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(02)75224-1
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to verify the reproducibility between two different observers of an analysis method for diaphragmatic displacement measurements using direct visualization with videofluoroscopy. PATIENTS AND METHODS:29 mouth breathing children aged 5 to 12 years from both genders were analyzed. ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2010.12.011
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Studies on inflammation biomarkers in serum and in exhaled breath condensate (EBC) in obstructive sleep apnea (OSA) have shown conflicting results. The objective of this study is to assess EBC and serum biomarkers in OSA patients at baseline and after continuous positive airway pressure (CPAP) or upper air...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2014.02.016
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Results supporting the use and the effectiveness of positive expiratory, pressure devices in chronic obstructive pulmonary disease (COPD) patients are still controversial, We have tested the hypothesis that adding TPEP or IPPB to standard pharmacological therapy may provide additional clinical benefit over, ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.arbres.2013.07.019
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Two previous national epidemiological studies, IBERPOC in 1997 and EPISCAN in 2007, determined the COPD burden in Spain. Changes in demographics and exposure to risk factors demand the periodic update of COPD prevalence and its determinants. METHODS:EPISCAN II aimed to estimate the prevalence of COPD in the...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2020.07.024
更新日期:2021-01-01 00:00:00
abstract::Infection of the larynx by Candida is rare and usually accompanies lung or disseminated candidiasis. The incidence of isolated laryngeal candidiasis (ILC) is low, although it may be underestimated. We describe 2 patients with ILC confirmed during autopsy: a 45-years-old male with pulmonary fibrosis and a 4-years-old g...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(15)30789-4
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:PLATINO project is a population-based study designed to determine the prevalence of chronic obstructive pulmonary disease (COPD) in São Paulo, Brazil; Mexico City, Mexico; Montevideo, Uruguay; Santiago de Chile, Chile; and Caracas, Venezuela. The objective of this portion of PLATINO was to describe preventive...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,多中心研究
doi:10.1016/s1579-2129(08)60016-6
更新日期:2008-02-01 00:00:00
abstract::This prospective descriptive study evaluated the utility of dobutamine in studying pulmonary vascular compliance in patients with lung neoplasms who are high risk candidates for lung resection. Seventeen consecutive patients meeting one of the following inclusion criteria were enrolled: FEV1 < 60% of theoretical value...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(15)30613-x
更新日期:1997-05-01 00:00:00
abstract::The diaphragm is the main muscle involved in ventilation and is supplied exclusively by the phrenic nerves. Congenital defects of the diaphragm muscle or phrenic nerve injury cause diaphragmatic paralysis-eventration. Prognosis and treatment depend on whether involvement is unilateral or bilateral and on the patient's...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:10.1016/S0300-2896(11)70066-7
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:In 1977 silica was listed as a group 1 carcinogen (demonstrated in humans) by the International Agency for Research on Cancer. However, conflicting results from various studies have kept debate alive as to its carcinogenic capacity. The interest of this debate lies in the large number of workers exposed to...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(02)75291-5
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Community-acquired pneumonia (CAP) is the leading cause of death from infectious disease among the elderly. This study was carried out to examine the clinical manifestations, etiology, prognostic factors and treatment of CAP in immunocompetent elderly patients requiring hospitalization. RESULTS:A total of 3...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(03)75400-3
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:The diagnosis of latent tuberculous infection (LTI) by IGRA continues to generate debate. Experience in the simultaneous use of 2 IGRA tests is scant. The aim of this study was to compare the results of 2 versions of QuantiFERON-TB Gold (In-Tube/Plus) with those of T-SPOT.TB, and to analyse the effectivene...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2020.04.011
更新日期:2020-06-10 00:00:00
abstract:INTRODUCTION:Red cell distribution width (RDW) describes heterogeneity in the size of red blood cells. An increase in RDW has been associated with excess mortality in heart failure and other chronic diseases. Since there is an increased risk of cardiovascular morbidity and mortality in obstructive sleep apnea (OSA), it...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2016.05.014
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION AND AIMS:Chronic inflammation plays a major role in lung deterioration in cystic fibrosis (CF) patients and anti-inflammatory strategies have beneficial effects. To study the changes seen after a one-year course of low-dose dietary supplements with a mixture of fatty acids in adult patients with CF in chro...
journal_title:Archivos de bronconeumologia
pub_type: 临床试验,杂志文章
doi:10.1016/j.arbres.2009.11.001
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:There is no specific health-related quality of life (HRQL) questionnaire that has been validated in Spanish for its use in patients with sleep apnea-hypopnea syndrome (SAHS). The objective of the present study was to validate the Spanish version of the Quebec Sleep Questionnaire (QSQ). PATIENTS AND METHOD...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2011.10.011
更新日期:2012-04-01 00:00:00
abstract::The clinical usefulness of simple exercise tests in patients with chronic obstructive pulmonary disease (COPD) continues to give rise to debate. Questions remain about whether these tests assess maximum effort or only exercise tolerance (submaximal effort). To determine the levels of stress reached during the six-minu...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(01)75017-x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:Citation analysis elucidates patterns of information consumption within professional communities. The aim of this study was to analyze the citations of 87 Spanish medical journals by calculating their impact factors and immediacy indices for 2001, and to estimate the importance of Archivos de Bronconeumología...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60376-5
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To study the general characteristics, health perception and limitations of patients with chronic obstructive pulmonary disease (COPD) treated at respiratory clinics at primary care centers staffed by pulmonologists from our hospital service. METHOD:The study was carried out at 5 primary care centers that enr...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(03)75437-4
更新日期:2003-11-01 00:00:00
abstract::We report the case of a 61-year-old man with amyotrophic lateral sclerosis presenting with respiratory failure requiring long-term mechanical ventilation. Diagnostic difficulties are discussed along with the circumstances that give rise to suspicion of neuromuscular disease in a context of respiratory failure of unkno...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:10.1016/s0300-2896(15)30324-0
更新日期:1999-01-01 00:00:00
abstract::Patient cooperation in controlling asthma is a key element for achieving the most efficient therapy possible according to current guidelines. Cooperation requires that the patient be adequately informed about his disease and able to make certain decisions. The aim of this study was to analyze whether patients really d...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,多中心研究
doi:10.1016/s0300-2896(15)30039-9
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic efficacy of pleural procedures, safety, delay and cost of the diagnosis of pleural effusion (PE) by analysing the parameters that are dependent on the area of patient management (outpatient or inpatient). PATIENTS AND METHODS:Prospective non-randomized study. Two groups were establ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2010.05.010
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The non-adherence to tuberculosis treatment is associated with increased infection, antibiotic resistance, increased costs and death. Our objective was to identify factors associated with lack of completion of conventional treatment for tuberculosis in Peru. PATIENTS AND METHODS:An unmatched case-control st...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2011.12.008
更新日期:2012-05-01 00:00:00
abstract::Pneumocephalus resulting from a subarachnoid-pleural fistula following resection of a pulmonary neoplasm is a very rare postoperative complication: we have found only 17 cases in the literature. We report the case of a 65-year-old man diagnosed with a superior sulcus tumor who underwent a left upper lobectomy and cost...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Spirometry is a basic lung function test useful both for measuring and for monitoring expiratory volume. For many years monitoring has been performed by means of a portable peak flow meter capable of measuring maximal expiratory flow. We present a portable spirometer (Spirotel, Medical International Research, Rome, It...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60190-0
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:In recent years, there has been debate regarding the diagnostic accuracy of computed tomography (CT) in the identification of lung metastases and the need for lung palpation to determine the number of metastatic nodules. The aim of this study was to determine in which patients the CT scan was more effectiv...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2013.05.006
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:The objective of this analysis was the evaluation of a new national circuit used for diagnosing alpha1 antitrypsin deficiency (AATD) based on multiplex technology using online registration and mail posted samples from dried blood spots (DBS) and buccal swabs. METHODS:This is an observational, ongoing stud...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2020.04.014
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To analyze the results of resection of lung metastases from colorectal adenocarcinoma in selected patients, evaluating type of resection, morbidity and mortality associated with the procedure, and overall actuarial survival rates after surgery. PATIENTS AND METHODS:Between 1988 and 1996, 811 patients were tr...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Recently, a number of reports have been published on silicosis in workers exposed to artificial quartz conglomerates containing high levels of crystalline silica particles (70-90%) used in the construction of kitchen and bathroom surfaces. Three cases of silicosis in workers exposed to artificial quartz conglomerates ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2014.12.010
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:To analyze the prevalence and evolution of tuberculous infection among 6-year-olds in Albacete and its relation to socioeconomic status of the family. METHOD:A tuberculin test (2UT RT-23 Tween 80) was given to 6-year-old school children in and around Albacete in 1992 and 1999. We calculated the prevalence o...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(02)75199-5
更新日期:2002-05-01 00:00:00