Abstract：
OBJECTIVE:As the research undertaken to date on the efficacy of the new antibiotics in the treatment of exacerbations of chronic bronchitis has taken the form of trials designed to demonstrate equivalence, we have no data on the advantages associated with the use of these new drugs with greater bactericidal activity. Our objective was to compare the clinical efficacy of moxifloxacin to that of the antibiotic regimens routinely used to treat such exacerbations by a systematic review of the literature and a meta-analysis. METHODS:A manual and electronic search was performed to identify all clinical trials carried out between January 1997 and July 2005 to compare moxifloxacin and the antibiotics that are currently the first line treatment for exacerbations of chronic bronchitis. Once it had been established that the designs of the trials included were acceptable, a meta-analysis of clinical outcomes was performed. RESULTS:Of the 45 studies identified, 9 met the inclusion criteria. Of these, 5 were double-blind randomized trials and 4 were randomized open trials. The 9 trials comprised a total of 3905 patients. The aggregate standardized mean difference in clinical success rate was 1.5% (95% confidence interval, -0.4 to 3.4%). Bacterial eradication rates ranged from 68.4% to 96% for the standard regimens, and from 87.7% to 96% for moxifloxacin. No intergroup differences in the percentages of patients lost to follow-up were observed in any of the studies. CONCLUSIONS:Although the trials reviewed were designed to demonstrate equivalence, meta-analysis revealed that the clinical success rate achieved with moxifloxacin tended to be higher than that obtained in the groups that received standard antibiotic treatment.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Miravitlles M,Molina J,Brosa Mdoi
10.1016/s1579-2129(07)60016-0subject
Has Abstractpub_date
2007-01-01 00:00:00pages
22-8issue
1eissn
0300-2896issn
1579-2129pii
13096997journal_volume
43pub_type
杂志文章,meta分析,评审abstract：:In lung transplantation, the presence of bronchogenic carcinoma in the native organ is uncommon, but doubtless affects patient survival, independently of the transplantation process itself. We describe 2 cases in which a primary tumor was found in the explanted lung--1 case of adenocarcinoma in a patient with pulmonar...
journal_title：Archivos de bronconeumologia
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abstract：INTRODUCTION AND OBJECTIVES:To determine the causes of death in patients operated on for stage IB non-small cell lung cancer (NSCLC) and to assess the impact on survival of the number of lymph nodes removed. PATIENTS AND METHOD:We studied 300 patients operated on for stage IB NSCLC. Only palpable or visible lymph node...
journal_title：Archivos de bronconeumologia
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journal_title：Archivos de bronconeumologia
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journal_title：Archivos de bronconeumologia
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journal_title：Archivos de bronconeumologia
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更新日期：2006-09-01 00:00:00
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更新日期：2020-02-29 00:00:00
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