Abstract：
OBJECTIVES:To analyze the results of thymectomy in our series of patients with myasthenia gravis (MG) and to study the influence of the most common prognostic factors. MATERIAL AND METHODS:Eighty MG patients over a period of 23 years underwent thymectomy consecutively in our hospital. Preoperative assessment included clinical evaluation of muscle weakness, edrophonium testing, electromyography, lung function testing, chest X-rays and CAT scans. Symptoms were assessed by the Osserman scale. The surgical approach was amplified transsternal thymectomy. The prognostic factors studied were sex, age, clinical stage, duration of disease before surgery and histology of the thymus. Clinical outcome was assessed using Millichap and Dodge's criteria. Follow-up was by the chest surgery and neurology departments. RESULTS:Complete remission was observed in 29 cases (36.2%) and significant improvement in 42 (52.5%). Complications developed in 9 patients (11.2%). Most patients were women (53/27) and outcomes for men and women were not statistically different. Mean age was 36 years (range 11-79), with no significant difference in outcome for patients who were older or younger than 60 years of age. Nor were differences evident related to presurgical clinical stage or levels of severity (I + IIa/IIb + III). Differences in outcome were highly significantly related to duration of disease (< 24 / > 24 months) (p = 0.0022), such that outcome was more satisfactory when the pre-surgical course of disease was shorter, provided that no thymoma was present. CONCLUSIONS:Amplified transsternal thymectomy was safe and effective for those patients with MG. When disease had been present for less than two years, the prognosis was better.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Vázquez-Pelillo J,Gil Alonso J,Díaz-Agero P,García Sánchez-Girón J,Roca Serrano R,Díez Tejedor E,Casillas Pajuelo Mdoi
10.1016/s0300-2896(01)75045-4keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
166-70issue
4eissn
0300-2896issn
1579-2129pii
S0300-2896(01)75045-4journal_volume
37pub_type
杂志文章abstract：:Spirometry is a basic lung function test useful both for measuring and for monitoring expiratory volume. For many years monitoring has been performed by means of a portable peak flow meter capable of measuring maximal expiratory flow. We present a portable spirometer (Spirotel, Medical International Research, Rome, It...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(06)60190-0
更新日期：2004-01-01 00:00:00
abstract：:We proposed to search for markers of hypercoagulable states in function of age, sex or factors that trigger venous thromboembolic disease (VTD) in a group of patients so diagnosed. The following patient data were analyzed: age, sex and triggering factors of VTD categorized as associative-transient, permanent or unknow...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:Massive hemoptysis is a life-threatening emergency that rarely occurs in association with heart failure and is even less frequent when the underlying cause is dilated myocardiopathy. We report the case of a 69-year-old man with undiagnosed heart disease who presented with severe hemoptysis. Images showed evident cardi...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(01)75092-2
更新日期：2001-07-01 00:00:00
abstract：:Traditional medical practice has been "reactive" (doctor takes part when disease appears). The theoretical (scale free networks and complex systems), technological (high efficiency "omic" technologies) and conceptual (biology systems) advances throughout the last decade, allow us to anticipate the transition to an "an...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2010.09.009
更新日期：2011-01-01 00:00:00
abstract：:Inpatient management of malignant pleural effusion includes the placement of a conventional thoracostomy tube for drainage and talc slurry pleurodesis and/or a surgical approach consisting of video-assisted thoracoscopic talc insufflation. Both techniques require prolonged hospital stays of up to 1 week. Unfortunately...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(07)60008-1
更新日期：2006-12-01 00:00:00
abstract：:Patient cooperation in controlling asthma is a key element for achieving the most efficient therapy possible according to current guidelines. Cooperation requires that the patient be adequately informed about his disease and able to make certain decisions. The aim of this study was to analyze whether patients really d...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/s0300-2896(15)30039-9
更新日期：1999-10-01 00:00:00
abstract：:Since antileukotriene treatment for asthma was introduced, there has been debate about whether such therapy can lead to Churg-Strauss Syndrome (CSS) or whether CSS is simply inhibited by the use of steroids, as various authors have suggested. We report a case in which we suspected CSS in a patient with bronchopulmonar...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/s0300-2896(01)75007-7
更新日期：2001-01-01 00:00:00
abstract：:It is unusual for pulmonologists to be familiar with the European and US regulations governing the administration of oxygen during air travel and each airline's policy in this respect. This lack of knowledge is in large part due to the scarcity of articles addressing this matter in specialized journals and the noticea...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2014.06.004
更新日期：2015-01-01 00:00:00
abstract：:Proliferating cell nuclear antigen (PCNA) is a 36 kD nuclear protein involved in DNA replication that is believed to provide an indication of proliferation in some neoplasms. This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded mat...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30798-5
更新日期：1996-03-01 00:00:00
abstract：:Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant is due to decreased clearance by the alveolar macrophages. Its p...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2015.02.003
更新日期：2015-07-01 00:00:00
abstract：:In non-small cell lung cancer, the EGFR gene mutations identify a patient sub-population with different clinical characteristics and treatment responses to those that do not have these mutations. There are mutations that derive in increased sensitive to EGFR targeted therapy, as well as mutations that result in resist...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2010.06.013
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:Magnesium sulfate has been shown to have a bronchodilating effect in asthma, but this effect has not been clearly established in the context of chronic obstructive pulmonary disease (COPD). For this reason we investigated the possible bronchodilating effect of magnesium sulfate in COPD exacerbations. PATIENT...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,随机对照试验
doi：10.1016/s1579-2129(06)60551-x
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION:Neuromuscular disease (NMD) patients frequently have impaired cough. Mechanical insufflation-exsufflation (MI-E) has proven efficacy in improving airway clearance, however data related to its long-term home use is lacking. The purpose of this study was to describe indications, safety and compliance of home...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/j.arbres.2010.04.011
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:Although an association between uric acid (UA) levels and obstructive sleep apnea (OSA) has been reported, the effect of continuous positive airway pressure (CPAP) on this measure is yet unclear. We aimed to investigate the effect of CPAP therapy on serum UA levels in patients with OSA. METHODS:We conducted...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.arbres.2018.09.012
更新日期：2019-04-01 00:00:00
abstract：:Although bacteria are the main pathogens involved in community-acquired pneumonia, a significant number of community-acquired pneumonia are caused by viruses, either directly or as part of a co-infection. The clinical picture of these different pneumonias can be very similar, but viral infection is more common in the ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2015.02.015
更新日期：2015-11-01 00:00:00
abstract：:The frequency of anemia may be higher than expected in patients with chronic obstructive pulmonary disease (COPD). Some studies have detected a prevalence of 33%, contrasting with the common idea that associates COPD with secondary polyglobulia. Among the risk factors associated with the development of anemia in these...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/S0300-2896(09)72864-9
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of in vivo gene therapy to treat subcutaneous tumors generated from murine lung cancer cells. MATERIAL AND METHODS:C57BL/6 mice received subcutaneus injections of 5 x 105 cells from the murine Lewis lung cancer cell line. By 10 days, subcutaneous tumors of approximately 5 mm diame...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Cytological characteristics are reported in the case of a 20-years-old male with pulmonary inflammatory pseudotumor (PIP) diagnosed by fine-needle aspiration (FNA) and later confirmed histologically. The patient presented a large tumor on the lower lobe of the right lung with hemoptysis, hemothorax and secondary acute...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:Chest ultrasound, a diagnostic technique used mainly by radiologists, is useful for managing pleural effusion. Sonography and computed tomography (CT) are complementary, although the former is more accessible to clinicians because it is safe and easy to use and because results are available quickly. We evaluated the u...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(03)75376-9
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:The PLATINO baseline study, conducted from 2003-2005 in five Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD). METHODS/DESIGN:A follow-up study was conducted in three out of the five centers (Montevideo, S...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.arbres.2013.07.014
更新日期：2014-01-01 00:00:00
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journal_title：Archivos de bronconeumologia
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.arbres.2014.11.001
更新日期：2015-04-01 00:00:00
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journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVE:To study the results of surgical treatment of pulmonary metastases in our department. PATIENTS AND METHODS:We retrospectively studied 44 patients undergoing surgery between 1986 and 1999 for complete resection of pulmonary metastases. Primary tumors had been eradicated, no metastasis to other organs was evid...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：UNLABELLED:The diaphragm seems to undergo adaptive structural change in chronic obstructive pulmonary disease. The possibility of obtaining muscle specimens is limited, however, particularly when respiratory function is severely affected. OBJECTIVE:To assess the viability of a new technique for obtaining diaphragm mus...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(15)30228-3
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To analyze prognostic factors associated with survival in a group of patients who underwent resection of pulmonary metastases from colorectal cancer. PATIENTS AND METHODS:A retrospective review was performed for 55 consecutive patients who had undergone resection of pulmonary metastases from colorectal adeno...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Although surgical pulmonary thromboendarterectomy is the treatment of choice for pulmonary hypertension due to chronic thrombotic and/or embolic disease, minimally invasive endovascular techniques such as angioplasty or placement of a metallic stent can provide acceptable results when surgery is not indicated...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s1579-2129(08)60051-8
更新日期：2008-06-01 00:00:00
abstract：:We report a patient with pneumonia and empyema secondary to an abdominal abscess due to Klebsiella pneumoniae from stones released into the abdominal cavity during laparoscopic cholecystectomy. ...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：10.1016/s0300-2896(01)75065-x
更新日期：2001-05-01 00:00:00
abstract：:Chlamydia pneumoniae has often been implicated in respiratory tract infections concomitant with other pathogens. Although this agent has also been associated with other nonrespiratory diseases, to our knowledge it has never been described with autoimmune hemolytic anemia. We present a case of pneumonia in which C. pne...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/s0300-2896(15)30772-9
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To determine if isoniazid- and/or rifampicin-free antituberculosis treatment regimens are safe and effective and to identify any factors that might require changes in the regimens. PATIENTS AND METHODS:We carried out a retrospective study of patients treated with isoniazid- and/or rifampicin-free regimens be...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Ventilator-associated pneumonia (VAP) is the first cause of mortality due to nosocomial infections in the intensive care unit. Its incidence ranges from 9% to 67% of patients on mechanical ventilation. Risk factors are multiple and are associated with prolonged stays in hospital and intensive care units. Additional co...
journal_title：Archivos de bronconeumologia
pub_type： 杂志文章,评审
doi：10.1016/j.arbres.2009.08.001
更新日期：2010-04-01 00:00:00
