Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma.

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become one of the leading etiologies of nosocomial pneumonia as a result of an increase in staphylococcal infections caused by methicillin-resistant strains paired with extended ventilatory support of critically, and often, chronically ill patients. The prevalence...

journal_title：Expert review of respiratory medicine

authors： Woods C,Colice G

更新日期：2014-10-01 00:00:00

abstract：:Aspergillus species are commonly isolated from lower respiratory tract samples of patients with cystic fibrosis (CF) and markers of immunological sensation to Aspergillus are frequently encountered in this group of patients; however, the contribution of Aspergillus to CF lung disease outside of the typical complicatio...

journal_title：Expert review of respiratory medicine

authors： Jones AM,Horsley A,Denning DW

更新日期：2014-08-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent antigen-presenting cells in the human lung and are now recognized as crucial initiators of immune responses in general. They are arranged as sentinels in a dense surveillance network inside and below the epithelium of the airways and alveoli, where they are ideally situated to...

journal_title：Expert review of respiratory medicine

authors： Blank F,von Garnier C,Obregon C,Rothen-Rutishauser B,Gehr P,Nicod L

更新日期：2008-04-01 00:00:00

abstract：:The management of pulmonary hypertension has already incorporated the use of multiple therapies into routine practice. Available therapies act principally through vasodilatation of the pulmonary arterial circulation through well-delineated mechanisms, although right ventricular function determines function and prognos...

journal_title：Expert review of respiratory medicine

authors： Mukherjee B,Howard L

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:A growing number of immunocompromised (IC) patients with acute hypoxemic respiratory failure (ARF) is admitted to the intensive care unit (ICU) worldwide. Areas covered: This review provides an overview of the current knowledge of the ways to prevent intubation in IC patients with ARF. Expert commentary: S...

journal_title：Expert review of respiratory medicine

authors： De Jong A,Calvet L,Lemiale V,Demoule A,Mokart D,Darmon M,Jaber S,Azoulay E

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatig...

journal_title：Expert review of respiratory medicine

authors： Schreiber T,Windisch W

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:The treatment of infection with Mycobacterium tuberculosis in young children is supported by universal policy based on strong rationale and evidence of effectiveness, but has rarely been implemented in tuberculosis endemic countries. Areas covered: This review highlights a number of important recent develo...

journal_title：Expert review of respiratory medicine

authors： Graham SM

更新日期：2017-01-01 00:00:00

abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：:Conducting clinical trials on pulmonary hypertension in the US and Western Europe has become increasingly difficult and costly because of many challenges. These include a limited patient population that makes recruitment difficult. Recruiting internationally has helped, but can add variability. The choice of end point...

journal_title：Expert review of respiratory medicine

authors： Hill NS,Roberts K,Preston I

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Pulmonary mold infections are caused by ubiquitous organisms found in soil, water, and decaying vegetation, including Aspergillus spp., the Mucormycetes, hyaline molds, and dematiaceous (black) molds. Areas covered: These infections are often a challenge to diagnose and even more difficult to treat. Recent...

journal_title：Expert review of respiratory medicine

authors： McCarthy MW,Petraitis V,Walsh TJ

更新日期：2017-06-01 00:00:00

abstract：:Although wheezing illness is at its most prevalent in infancy and early childhood, its self-limiting nature in the majority poses considerable challenges in offering a long-term prognosis and in initiating long-term prophylaxis. Many of the established treatments in adults have not been adequately assessed in children...

journal_title：Expert review of respiratory medicine

authors： Helms PJ

更新日期：2009-04-01 00:00:00

abstract：:For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area of in vitro immunodiagn...

journal_title：Expert review of respiratory medicine

authors： Ruhwald M,Ravn P

更新日期：2009-08-01 00:00:00

abstract：:Since chronic obstructive pulmonary disease (COPD) has a progressive and major impact on health management, many aspects of this disorder, including development of effective and reliable biomarkers to monitor disease progression, are under intensive investigation. A huge amount of data, accumulated over the years, hav...

journal_title：Expert review of respiratory medicine

authors： Iadarola P,Luisetti M

更新日期：2013-04-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：:Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm activity following spinal cord injury have been narrowly focused on ventilation. By contrast, the understanding of neuromotor control for non-ventilatory expulsive/straining maneuvers (including coughing, defecation, and parturition) is...

journal_title：Expert review of respiratory medicine

authors： Fogarty MJ,Sieck GC

更新日期：2020-05-01 00:00:00

abstract：:Budesonide/formoterol is a combination of an inhaled corticosteroid plus a long-acting beta(2)-agonist available as a dry-powder inhaler for the indication of asthma and chronic obstructive pulmonary disease in various countries outside of the USA and as a pressurized metered-dose inhaler in the USA for the indication...

journal_title：Expert review of respiratory medicine

authors： Lee C,Corren J

更新日期：2008-10-01 00:00:00

abstract：:Childhood obstructive sleep disordered breathing (OSDB), a sleep-related upper airway obstruction that degrades sleep quality, ventilation and/or oxygenation, in turn leads to a variety of daytime symptoms and morbidity. In the past, childhood OSDB was classified into primary snoring versus obstructive sleep apnea (OS...

journal_title：Expert review of respiratory medicine

authors： Jambhekar S,Carroll JL

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:The treatment of lung cancer has radically changed over the last few years. The discovery of druggable oncogenic alterations and the introduction of immunotherapy have provided lung cancer patients with the possibility of more efficient and less toxic therapeutic alternatives than chemotherapy. In the case...

journal_title：Expert review of respiratory medicine

authors： Lazzari C,Karachaliou N,Gregorc V,Bulotta A,Gonzalez-Cao M,Verlicchi A,Altavilla G,Rosell R,Santarpia M

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Pleural disease encompasses a large range of conditions, is a common presentation to the acute medical take and often requires comprehensive investigation and treatment. Ultrasound is well recognised as a useful investigative tool in pleural disease especially in the field of pleural effusion, pleural thic...

journal_title：Expert review of respiratory medicine

authors： Mercer RM,Psallidas I,Rahman NM

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise into...

journal_title：Expert review of respiratory medicine

authors： Babu AS,Morris NR,Arena R,Myers J

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Anemia is often seen in chronic obstructive pulmonary disease (COPD) patients. However, the implications of anemia on the outcomes of patients with COPD is not clearly known. Therefore, we conducted a systematic review and meta-analysis to evaluate the effects of anemia on the morbidity and mortality of pati...

journal_title：Expert review of respiratory medicine

authors： Xu Y,Hu T,Ding H,Chen R

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Lung Clearance Index, measured using the multiple breath washout (MBW) technique, may be a useful test in infants with Cystic Fibrosis (CF). However, the requirement for specialised equipment and a number of important technical and methodological considerations relevant to testing in infants have complicat...

journal_title：Expert review of respiratory medicine

authors： Davies G,Aurora P

更新日期：2017-01-01 00:00:00

abstract：:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the survival of patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. However, nearly all EGFR-mutant NSCLC tumors eventually acquire resistance to the currently used EGFR-TKIs a...

journal_title：Expert review of respiratory medicine

authors： Noda S,Kanda S

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Survival after lung transplantation lags behind outcomes of other solid organ transplants, and complications from lung transplant are the second most common cause of death in cystic fibrosis. Evolving surgical techniques, therapeutics, and perioperative management have improved short-term survival after lu...

journal_title：Expert review of respiratory medicine

authors： Li SS,Tumin D,Krone KA,Boyer D,Kirkby SE,Mansour HM,Hayes D Jr

更新日期：2018-11-01 00:00:00

abstract：:The hallmarks of allergic bronchial asthma arise from chronic airway inflammation. Thus, elucidating the mechanisms regulating the maintenance of this chronic inflammatory response is key to understanding asthma pathogenesis. To date, it is not clear whether a predominance of proinflammatory factors or a reduced capac...

journal_title：Expert review of respiratory medicine

authors： Lunding L,Schröder A,Wegmann M

更新日期：2015-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a very common disease all around the world and has become an increasing public health concern to the Chinese medical community. In the past decades, telehealthcare technology has become a good way to manage COPD but current evidence makes it hard to determine the effecti...

journal_title：Expert review of respiratory medicine

authors： Lao X,Zhang J,Bai C

更新日期：2013-10-01 00:00:00

abstract：:In many countries numbers of adults with cystic fibrosis (CF) exceed that of children, with median survival predicted to surpass 50 years. Increasing longevity is, in part, due to intensive therapies including eradication of early infection and suppressive therapies and pulmonary exacerbations. Initial infections with...

journal_title：Expert review of respiratory medicine

authors： Ramsay KA,Stockwell RE,Bell SC,Kidd TJ

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) is an autosomal dominant chloride channelopathy caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results clinically in a multisystem disorder. The major source of morbidity and mortality in CF is lung disease, which is characterized by recurrent cycles...

journal_title：Expert review of respiratory medicine

authors： McElvaney OJ,Gunaratnam C,McElvaney OF,Bagwe I,Reeves EP,McElvaney NG

更新日期：2018-10-01 00:00:00

abstract：:The historic perspective that used to define chronic obstructive pulmonary disease has changed. As reviewed in this article, it is based on a better understanding of the underlying inflammatory airflow obstruction and a multidimensional classification, which mostly targets a subgroup called 'frequent exacerbators'. Cl...

journal_title：Expert review of respiratory medicine

authors： Noujeim C,Bou-Khalil P

更新日期：2013-08-01 00:00:00

abstract：:Lung transplantation has evolved over the past two decades as a well-recognized therapy for patients with end-stage lung diseases. However, lung transplantation has been limited, in part, due to the scarcity of donor lung organs. Previously, donor lung organs were allocated based on a potential recipient's waiting lis...

journal_title：Expert review of respiratory medicine

authors： Stern E,Bhorade SM

更新日期：2008-08-01 00:00:00