Different correlation of sphingosine-1-phosphate receptor 1 with receptor activator of nuclear factor kappa B ligand and regulatory T cells in rat periapical lesions.


INTRODUCTION:Sphingosine-1-phosphate receptor 1 (S1P1) is crucial for regulation of immunity and bone metabolism. This study aimed to investigate the expression of S1P1 in rat periapical lesions and its relationship with receptor activator of nuclear factor kappa B ligand (RANKL) and regulatory T (Treg) cells. METHODS:Periapical lesions were induced by pulp exposure in the first lower molars of 55 Wistar rats. Thirty rats were killed on days 0, 7, 14, 21, 28, and 35, and their mandibles were harvested for x-ray imaging, micro-computed tomography scanning, histologic observation, immunohistochemistry, enzyme histochemistry, and double immunofluorescence analysis. The remaining 25 rats were killed on days 0, 14, 21, 28, and 35, and mandibles were harvested for flow cytometry. RESULTS:The volume and area of the periapical lesions increased from day 0 to day 21 and then remained comparably stable after day 28. S1P1-positive cells were observed in the inflammatory periapical regions; the number of S1P1-positive cells peaked at day 14 and then decreased from day 21 to day 35. The distribution of S1P1-positive cells was positively correlated with the dynamics of RANKL-positive cells but was negatively correlated with that of Treg cells. CONCLUSIONS:S1P1 expression was differentially correlated with RANKL and Treg cell infiltration in the periapical lesions and is therefore a contributing factor to the pathogenesis of such lesions.


J Endod


Journal of endodontics


Xiao L,Zhu L,Yang S,Lei D,Xiao Y,Peng B




Has Abstract


2015-04-01 00:00:00














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    journal_title:Journal of endodontics

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    authors: Cailleteau JG,Rieger MR,Akin JE

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    authors: de Leimburg ML,Angeretti A,Ceruti P,Lendini M,Pasqualini D,Berutti E

    更新日期:2004-12-01 00:00:00

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    authors: Rodrigues MP,Soares PBF,Valdivia ADCM,Pessoa RS,Veríssimo C,Versluis A,Soares CJ

    更新日期:2017-09-01 00:00:00

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    authors: Tingey MC,Bush P,Levine MS

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    更新日期:2020-08-11 00:00:00

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    更新日期:2019-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Donnelly JC

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    journal_title:Journal of endodontics

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    authors: Yue W,Kim E

    更新日期:2016-04-01 00:00:00

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Katz H

    更新日期:2005-11-01 00:00:00

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Zhang Q,Chen H,Fan B,Fan W,Gutmann JL

    更新日期:2014-06-01 00:00:00

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Akisue E,Gratieri SD,Barletta FB,Caldeira CL,Grazziotin-Soares R,Gavini G

    更新日期:2014-01-01 00:00:00

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Berutti E

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Matsuo T,Shirakami T,Ozaki K,Nakanishi T,Yumoto H,Ebisu S

    更新日期:2003-03-01 00:00:00

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    authors: Silva Almeida LH,Moraes RR,Morgental RD,Pappen FG

    更新日期:2017-04-01 00:00:00

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    journal_title:Journal of endodontics

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    authors: Brady JM,del Rio CE

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    authors: Machtou P,Sarfati P,Cohen AG

    更新日期:1989-11-01 00:00:00

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    journal_title:Journal of endodontics

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    authors: Bornstein MM,Wasmer J,Sendi P,Janner SF,Buser D,von Arx T

    更新日期:2012-01-01 00:00:00

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    authors: Kuraner T,Ozçelik B,Serper A,Mocan G,Mümin E,Eryilmaz M

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    更新日期:2014-10-01 00:00:00

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    更新日期:2009-07-01 00:00:00

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    authors: Matsumoto S,Hayashi M,Suzuki Y,Suzuki N,Maeno M,Ogiso B

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    pub_type: 杂志文章


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    更新日期:2012-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Pigg M,Nixdorf DR,Nguyen RH,Law AS,National Dental Practice-Based Research Network Collaborative Group.

    更新日期:2016-06-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Journal of endodontics

    pub_type: 杂志文章


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    更新日期:2006-07-01 00:00:00