Nucleoporin MOS7/Nup88 is required for mitosis in gametogenesis and seed development in Arabidopsis.

abstract：:Preincubation of quiescent BALB/C3T3 cells with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) in conditioned medium resulted in a time- and concentration-dependent stimulation of uptake of 2-deoxyglucose, uridine, and alpha-aminoisobutyric acid over that seen in conditioned medium alone. The apparent Km values ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Natraj CV,Datta P

更新日期：1978-08-01 00:00:00

abstract：:The replisome, the multiprotein system responsible for genome duplication, is a highly dynamic complex displaying a large number of different enzyme activities. Recently, the Saccharomyces cerevisiae minimal replication reaction has been successfully reconstituted in vitro. This provided an opportunity to uncover the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis JS,Spenkelink LM,Schauer GD,Hill FR,Georgescu RE,O'Donnell ME,van Oijen AM

更新日期：2017-10-03 00:00:00

abstract：:Chromopeptides were prepared by proteolytic digestion of phytochrome (far-red absorbing form, P(fr)) and of phycocyanin. The phycocyanobilin peptide, the chromophore of which is Z,Z,Z-configurated, was modified to the Z,Z,E isomeric chromophore. It has been demonstrated earlier that the P(fr) chromopeptide and the Z,Z...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rüdiger W,Thümmler F,Cmiel E,Schneider S

更新日期：1983-10-01 00:00:00

abstract：:The three-dimensional structure of O,O',N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its pharmacologic action. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobell HM,Sakore TD,Tavale SS,Canepa FG,Pauling P,Petcher TJ

更新日期：1972-08-01 00:00:00

abstract：:Coxsackievirus causes severe disease in adult mice subjected to sustained post-weaning undernutrition (marasmus). Virus-infected marasmic mice have an increased incidence of mortality, severe lesions, and elevated and persistent viral in target organs. Transfer of immune lymphoid cells 30 min or 24 hr after viral chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woodruff JF,Woodruff JJ

更新日期：1971-09-01 00:00:00

abstract：:Vaccination is the most effective medical intervention ever introduced and, together with clean water and sanitation, it has eliminated a large part of the infectious diseases that once killed millions of people. A recent study concluded that since 1924 in the United States alone, vaccines have prevented 40 million ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rappuoli R,Pizza M,Del Giudice G,De Gregorio E

更新日期：2014-08-26 00:00:00

abstract：:Assembly of protein complexes is a key mechanism for achieving spatial and temporal coordination in processes involving many enzymes. Growth of rod-shaped bacteria is a well-studied example requiring such coordination; expansion of the cell wall is thought to involve coordination of the activity of synthetic enzymes w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TK,Tropini C,Hsin J,Desmarais SM,Ursell TS,Gong E,Gitai Z,Monds RD,Huang KC

更新日期：2014-03-25 00:00:00

abstract：:Although x-ray crystallography is the most widely used method for macromolecular structure determination, it does not provide dynamical information, and either experimental tricks or complementary experiments must be used to overcome the inherently static nature of crystallographic structures. Here we used specific x-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colletier JP,Bourgeois D,Sanson B,Fournier D,Sussman JL,Silman I,Weik M

更新日期：2008-08-19 00:00:00

abstract：:Historically, the biodiversity and composition of species in a locality was thought to be influenced primarily by deterministic factors. In such cases, species' niches create differential responses to environmental conditions and interspecific interactions, which combine to determine that locality's biodiversity and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chase JM

更新日期：2007-10-30 00:00:00

abstract：:ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed at minimizing false-positive transcription factor targets. We present a model with improve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margolin AA,Palomero T,Sumazin P,Califano A,Ferrando AA,Stolovitzky G

更新日期：2009-01-06 00:00:00

abstract：:We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards LJ,Murphy M,Dutton R,Kilpatrick TJ,Puche AC,Key B,Tan SS,Talman PS,Bartlett PF

更新日期：1995-10-24 00:00:00

abstract：:Tadpole collagenase (EC 3.4.24.3) cleaved chick cranial bone procollagen into two triple-stranded fragments, PCA and PCB. Only PCB, with an estimated molecular weight of about 60,000 for each component chain after reduction, was found to contain interchain disulfide bonds. The analogous cleavage of collagen is known t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers PH,Click EM,Harper E,Bornstein P

更新日期：1975-08-01 00:00:00

abstract：:We have compared the process of prophage lambda induction with that of prophage Mu. According to the Campbell model, rescue of lambda DNA from the host DNA involves reversal of lambda integration such that the prophage DNA is excised from the host chromosome. We have monitored this event by locating the prophage DNA w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ljungquist E,Bukhari AI

更新日期：1977-08-01 00:00:00

abstract：:Pinus taeda L. (loblolly pine) and Arabidopsis thaliana differ greatly in form, ecological niche, evolutionary history, and genome size. Arabidopsis is a small, herbaceous, annual dicotyledon, whereas pines are large, long-lived, coniferous forest trees. Such diverse plants might be expected to differ in a large numbe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirst M,Johnson AF,Baucom C,Ulrich E,Hubbard K,Staggs R,Paule C,Retzel E,Whetten R,Sederoff R

更新日期：2003-06-10 00:00:00

abstract：:Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Crowther RA,Jakes R,Hasegawa M,Goedert M

更新日期：1998-05-26 00:00:00

abstract：:Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active nonadenylylated form in response to nitrogen limitation. In these mutants the PII regulatory protein is altered such that it cannot be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foor F,Reuveny Z,Magasanik B

更新日期：1980-05-01 00:00:00

abstract：:Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaldivar D,Rauch A,Logothetis NK,Goense J

更新日期：2018-12-18 00:00:00

abstract：:Measurements of the effect of DNA on rates of bimolecular energy transfer between ions provide a direct indication of how cations cluster in regions near DNA and how anions are repelled from the same regions. Energy transfer from luminescent lanthanide ions (in the "rapid-diffusion" limit) probes collision frequencies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wensel TG,Meares CF,Vlachy V,Matthew JB

更新日期：1986-05-01 00:00:00

abstract：:Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection and induces tolerance in experimental acute allograft rejection models. We tested the effect of CTLA4Ig therapy on the process of chronic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azuma H,Chandraker A,Nadeau K,Hancock WW,Carpenter CB,Tilney NL,Sayegh MH

更新日期：1996-10-29 00:00:00

abstract：:We have previously shown that geographic differences in cancer mortalities in Europe are related to (in order of importance): geographic distances (reflecting environmental differences), ethnohistoric distances (encompassing cultural and genetic attributes), and genetic distances of the populations in the areas studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokal RR,Oden NL,Rosenberg MS,Thomson BA

更新日期：2000-05-23 00:00:00

abstract：:The type VI secretion system (T6SS) is a lethal weapon used by many bacteria to kill eukaryotic predators or prokaryotic competitors. Killing by the T6SS results from repetitive delivery of toxic effectors. Despite their importance in dictating bacterial fitness, systematic prediction of T6SS effectors remains challen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang X,Moore R,Wilton M,Wong MJ,Lam L,Dong TG

更新日期：2015-07-21 00:00:00

abstract：:We have studied the expression of simian virus 40 (SV40) specific tumor antigen (T-antigen) and viral RNA in SV40-transformed mouse 3T3 cells that are temperature-sensitive for the expression of the transformed phenotype (ts SV3T3). Although transformed by wild-type SV40, ts SV3T3 cells at 32 degrees behave like stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basilico C,Zouzias D

更新日期：1976-06-01 00:00:00

abstract：:Escherichia coli phage N4 transcription is resistant to rifampicin, an inhibitor of the host RNA polymerase, even when the drug is added prior to infection. A rifampicin-resistant RNA polymerase has been detected in disrupted N4 virions. This enzyme shows a requirement for the four ribonucleoside 5'-triphosphates and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falco SC,Laan KV,Rothman-Denes LB

更新日期：1977-02-01 00:00:00

abstract：:The zinc finger transcription factor Miz1 is a negative regulator of TNFalpha-induced JNK activation and cell death through inhibition of TRAF2 K63-polyubiquitination in a transcription-independent manner. Upon TNFalpha stimulation, Miz1 undergoes K48-linked polyubiquitination and proteasomal degradation, thereby reli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Do H,Tian X,Zhang C,Liu X,Dada LA,Sznajder JI,Liu J

更新日期：2010-07-27 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:Examples of finite-dimensional Hopf algebras over a field, whose antipodes have arbitrary even orders >/=4 as mappings, are furnished. The dimension of the Hopf algebra is q(n+1), where the antipode has order 2q, q >/= 2, and n is an arbitrary positive integer. The algebras are not semisimple, and neither they nor the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taft EJ

更新日期：1971-11-01 00:00:00

abstract：:Non-human primates (NHP) provide crucial research models. Their strong similarities to humans make them particularly valuable for understanding complex behavioral traits and brain structure and function. We report here the genetic mapping of an NHP nervous system biologic trait, the cerebrospinal fluid (CSF) concentra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freimer NB,Service SK,Ophoff RA,Jasinska AJ,McKee K,Villeneuve A,Belisle A,Bailey JN,Breidenthal SE,Jorgensen MJ,Mann JJ,Cantor RM,Dewar K,Fairbanks LA

更新日期：2007-10-02 00:00:00

abstract：:Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts have been defined. Nuclear extracts prepared from cells permissively infected with the adenovirus mutant H5ts125 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan LM,Ariga H,Hurwitz J,Horwitz MS

更新日期：1979-11-01 00:00:00

abstract：:Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llodrá J,Angeli V,Liu J,Trogan E,Fisher EA,Randolph GJ

更新日期：2004-08-10 00:00:00

abstract：:Experimental circular dichroic (CD) spectra of three proteins have been combined with estimates of the content of peptide-chain structural modes obtained from x-ray diffraction studies of the same proteins. Solution of the simultaneous equations at a series of wavelengths permits the construction of a CD spectrum for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxena VP,Wetlaufer DB

更新日期：1971-05-01 00:00:00