Abstract:
:The innate immune system is the first line of defense against microbial pathogens, but tight regulation of gene expression is necessary to prevent the detrimental effects of unrestrained activation. Although the functions of most long noncoding RNAs (lncRNAs; >200 nucleotides) are unknown, many have been shown to regulate diverse cellular activities. Recent reports by us and others have suggested that lncRNAs may also play critical roles in transcriptional regulation of gene expression during innate immune responses. Following engagement of Toll-like receptors, lncRNAs form functional RNA-protein complexes that recruit activators or remove repressors of transcription, leading to rapid expression of inflammatory mediators. These discoveries suggest that lncRNAs may contribute to the gene regulatory networks that govern host-pathogen interactions.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Li Z,Rana TMdoi
10.4161/rna.29937subject
Has Abstractpub_date
2014-01-01 00:00:00pages
979-85issue
8eissn
1547-6286issn
1555-8584journal_volume
11pub_type
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