Abstract:
:The innate immune system is the first line of defense against microbial pathogens, but tight regulation of gene expression is necessary to prevent the detrimental effects of unrestrained activation. Although the functions of most long noncoding RNAs (lncRNAs; >200 nucleotides) are unknown, many have been shown to regulate diverse cellular activities. Recent reports by us and others have suggested that lncRNAs may also play critical roles in transcriptional regulation of gene expression during innate immune responses. Following engagement of Toll-like receptors, lncRNAs form functional RNA-protein complexes that recruit activators or remove repressors of transcription, leading to rapid expression of inflammatory mediators. These discoveries suggest that lncRNAs may contribute to the gene regulatory networks that govern host-pathogen interactions.
journal_name
RNA Bioljournal_title
RNA biologyauthors
Li Z,Rana TMdoi
10.4161/rna.29937subject
Has Abstractpub_date
2014-01-01 00:00:00pages
979-85issue
8eissn
1547-6286issn
1555-8584journal_volume
11pub_type
杂志文章相关文献
RNA Biology文献大全abstract::The chromatoid body is a large perinuclear ribonucleoprotein particle of germ cells. The chromatoid body is also present in stem cells from planarians. This particle shares markers specific to protein aggresomes and P-bodies, and concentrate several RNA pathways. The assembly mechanism of chromatoid bodies is unknown,...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.2.8049
更新日期:2009-04-01 00:00:00
abstract::The endoribonuclease RNase-L requires 2',5'-linked oligoadenylates for activation, and mediates antiviral and antiproliferative activities. We previously determined that RNase-L activation induces senescence; to determine potential mechanisms underlying this activity, we used microarrays to identify RNase-L-regulated ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.3.8526
更新日期:2009-07-01 00:00:00
abstract::Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experi...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.1.7574
更新日期:2009-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is licenced by the ribonuclease (RNase) III enzyme Drosha, the regulatio...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1813439
更新日期:2020-11-01 00:00:00
abstract::MicroRNA (miRs) are short non-coding RNAs that fine-tune the regulation of gene expression to coordinate a wide range of biological processes. MicroRNAs are transcribed from miR genes and primary miR transcripts are processed to approximately 22 nucleotide single strand mature forms that function as repressors of tran...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.28141
更新日期:2014-01-01 00:00:00
abstract::Deinococcus radiodurans is a highly stress resistant bacterium that encodes universal as well as lineage-specific factors involved in DNA transcription and repair. However, the effects of DNA lesions on RNA synthesis by D. radiodurans RNA polymerase (RNAP) have never been studied. We investigated the ability of this R...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1656027
更新日期:2019-12-01 00:00:00
abstract::The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing an...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.1080/15476286.2016.1240143
更新日期:2016-12-01 00:00:00
abstract::tmRNA employs both tRNA-like and mRNA-like properties as it rescues stalled bacterial ribosomes, while targeting the defective mRNA and incomplete nascent protein for degradation. We describe variation of the tmRNA gene (ssrA) and how it informs tmRNA structure and function. Endosymbiont tmRNAs tend to lose secondary ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.6.4.9172
更新日期:2009-09-01 00:00:00
abstract::Alternative splicing (AS) plays a central role during cell-fate determination. However, how the core spliceosomal factors (CSFs) are involved in this process is poorly understood. Here, we report the down-regulation of the U2AF1 CSF during stem cell differentiation. To investigate its function in stemness and differen...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1733800
更新日期:2020-06-01 00:00:00
abstract::We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 prom...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1673656
更新日期:2020-02-01 00:00:00
abstract::The RIG-I-like receptors (RLRs)--RIG-I, MDA5, and LGP2--detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for sig...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.27717
更新日期:2014-01-01 00:00:00
abstract::The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for their distinct activi...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1860376
更新日期:2020-12-23 00:00:00
abstract::Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding error (mistranslat...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.32199
更新日期:2014-01-01 00:00:00
abstract::A very conserved pseudoknot structure has been shown to fold in influenza virus RNA. The pseudoknot encompasses the 3' splice site of segment 8 RNA in both influenza A and B viruses. By sequence comparison of influenza virus strains, we derive a consensus motif that defines a novel RNA pseudoknot family. The orientati...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7.2.11287
更新日期:2010-03-01 00:00:00
abstract::The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26249
更新日期:2013-10-01 00:00:00
abstract::While disruption of alternative splicing underlies many diseases, modulation of splicing using antisense oligonucleotides (AONs) can have therapeutic implications. The most notable example is Duchenne muscular dystrophy (DMD), where antisense-mediated exon skipping can restore the open reading frame and allow the synt...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.4.12264
更新日期:2010-07-01 00:00:00
abstract::The non-coding roX1 and roX2 RNAs are components of the MSL dosage compensation complex in Drosophila. We found that multiple species of roX2 RNA are produced by alternative splicing, with one major and at least 20 different minor forms associated with MSL proteins. The alternative forms are generated by variable usag...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.2.4.2473
更新日期:2005-10-01 00:00:00
abstract::The quaking viable (qk(v)) mice have attracted attention because of their characteristic tremor caused by their dysmyelination. In the central nervous system, qk(v) mice fail to develop mature myelinating oligodendrocytes and display uncompacted myelin. The genetic defect in the qk(v) mice prevents the proper expressi...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.2.2.1603
更新日期:2005-04-01 00:00:00
abstract::The muscle specific miRNA, miR-206, is important for the process of myogenesis; however, studying the function of miR-206 in muscle development and differentiation still proves challenging because the complement of mRNA targets it regulates remains undefined. In addition, miR-206 shares close sequence similarity to mi...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2020.1737443
更新日期:2020-07-01 00:00:00
abstract::Type II CRISPR-Cas9 systems require a small RNA called the trans-activating CRISPR RNA (tracrRNA) in order to function. The prediction of these non-coding RNAs in prokaryotic genomes is challenging because they have dissimilar structures, having short stems (3-6 bp) and non-canonical base-pairs e.g. G-A. Much of the t...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2018.1498281
更新日期:2019-04-01 00:00:00
abstract::Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture experiments expanded the repertoire of cellular RBPs quiet dramatically, little is known about the assembly of RBPs on particular ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2019.1662268
更新日期:2020-01-01 00:00:00
abstract::In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent premRNA splicing occurs in humans, which contributes to the regulation of alternative sp...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.6.4.9318
更新日期:2009-09-01 00:00:00
abstract::Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the transcriptional and post-transcriptional levels. In both cases, regulatory sequences placed at either promoter regions or on UTRs function as markers recognized by regulators...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.7116
更新日期:2008-10-01 00:00:00
abstract::Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The mechanism of P-body assembly has been typically addressed by depleting P-body components. Here we apply a complementary approach and establish an automated cell-...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.26851
更新日期:2013-11-01 00:00:00
abstract::Significant structural and mechanistic similarities between the spliceosomal snRNAs and catalytically critical domains of self-splicing group II introns have led to the hypothesis that the spliceosomes and group II introns may be evolutionarily related. We have previously shown that in vitro-transcribed, protein-free ...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.4161/rna.8.3.15386
更新日期:2011-05-01 00:00:00
abstract::A recent study revealed that poly(A)-binding protein (PABP) bound to poly(A) RNA exhibits a sharply bent configuration at the linker region between RNA-recognition motif 2 (RRM2) and RRM3, whereas free PABP exhibits a highly flexible linear configuration. However, the physiological role of the bent structure of mRNA-b...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1280224
更新日期:2017-03-04 00:00:00
abstract::MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies hav...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.20018
更新日期:2012-06-01 00:00:00
abstract::The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's fun...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.6.14115
更新日期:2010-11-01 00:00:00
abstract::Single-stranded oligonucleotides (ssOligos) are efficiently taken up by living cells without the use of transfection reagents. This phenomenon called 'gymnosis' enables the sequence-specific silencing of target genes in various types of cells. Several antisense ssOligos are used for the treatment of human diseases. Ho...
journal_title:RNA biology
pub_type: 杂志文章
doi:10.1080/15476286.2017.1302641
更新日期:2017-11-02 00:00:00
abstract::Riboswitches are cis-encoded, cis-acting RNA elements that directly sense a physiological signal. Signal response results in a change in RNA structure that impacts gene expression. Elements of this type play an important role in bacteria, where they regulate a variety of fundamental cellular pathways. Riboswitch-media...
journal_title:RNA biology
pub_type: 杂志文章,评审
doi:10.4161/rna.7.1.10757
更新日期:2010-01-01 00:00:00