当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Highly stable aptamers selected from a 2'-fully modified fGmH RNA library for targeting biomaterials.

Highly stable aptamers selected from a 2'-fully modified fGmH RNA library for targeting biomaterials.

Abstract：

:When developed as targeting ligands for the in vivo delivery of biomaterials to biological systems, RNA aptamers immediately face numerous obstacles, in particular nuclease degradation and post-selection 2' modification. This study aims to develop a novel class of highly stable, 2'-fully modified RNA aptamers that are ideal for the targeted delivery of biomaterials. We demonstrated the facile transcription of a fGmH (2'-F-dG, 2'-OMe-dA/dC/dU) RNA library with unexpected hydrophobicity, the direct selection of aptamers from a fGmH RNA library that bind Staphylococcus aureus Protein A (SpA) as a model target, and the superior nuclease and serum stability of these aptamers compared to 2'-partially modified RNA variants. Characterizations of fGmH RNA aptamers binding to purified SpA and to endogenous SpA present on the surface of S. aureus cells demonstrate fGmH RNA aptamer selectivity and stability. Significantly, fGmH RNA aptamers were able to functionalize, stabilize, and specifically deliver aggregation-prone silver nanoparticles (AgNPs) to S. aureus with SpA-dependent antimicrobial effects. This study describes a novel aptamer class with considerable potential to improve the in vivo applicability of nucleic acid-based affinity molecules to biomaterials.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Friedman AD,Kim D,Liu R

doi

10.1016/j.biomaterials.2014.08.046

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

110-23

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(14)00983-1

journal_volume

36

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Auto-fluorescent polymer nanotheranostics for self-monitoring of cancer therapy via triple-collaborative strategy.

    abstract：:Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently aga...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.12.021

    authors： Shao L,Li Q,Zhao C,Lu J,Li X,Chen L,Deng X,Ge G,Wu Y

    更新日期：2019-02-01 00:00:00

  • The mechanical properties of the skin epidermis in relation to targeted gene and drug delivery.

    abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2007.08.006

    authors： Kendall MA,Chong YF,Cock A

    更新日期：2007-11-01 00:00:00

  • Interactions between meniscal cells and a self assembled biomimetic surface composed of hyaluronic acid, chitosan and meniscal extracellular matrix molecules.

    abstract：:Menisci are one of the most commonly injured parts of the knee with a limited healing potential. This study focuses on fabrication and characterization of biomimetic surfaces for meniscal tissue engineering. To achieve this, a combination of hyaluronic acid/chitosan (HA/CH) mutilayers with covalently immobilized major...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.04.018

    authors： Tan GK,Dinnes DL,Butler LN,Cooper-White JJ

    更新日期：2010-08-01 00:00:00

  • Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium.

    abstract：:The heart possesses a complex three-dimensional (3D) laminar myofiber organization; however, because engineering physiologically relevant 3D tissues remains a technical challenge, the effects of cardiomyocyte alignment on excitation-contraction coupling, shortening and force development have not been systematically st...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120204

    authors： Liu J,Miller K,Ma X,Dewan S,Lawrence N,Whang G,Chung P,McCulloch AD,Chen S

    更新日期：2020-10-01 00:00:00

  • Studies on radio-opaque polymeric biomaterials with potential applications to endovascular prostheses.

    abstract：:A new polymeric biomaterial, which uniquely combines radio-opacity (X-ray visibility) and low thrombogenicity, is described. First, preparation, purification, and identification of the essential monomeric building block, 2-[2'-iodobenzoyl]-ethyl methacrylate (3), are outlined. Second, [Figure: See text] the synthesis ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(95)00339-8

    authors： Kruft MA,Benzina A,Blezer R,Koole LH

    更新日期：1996-09-01 00:00:00

  • Targeted drug delivery for tumor therapy inside the bone marrow.

    abstract：:Bone marrow is the primary hematopoietic organ, which is involved in multiple malignant diseases including acute and chronic leukemia, multiple myeloma, myelodysplastic syndromes, and bone metastases from solid tumors. These malignancies affect normal homeostasis and reshape the bone marrow microenvironment. There are...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2017.11.029

    authors： Mu CF,Shen J,Liang J,Zheng HS,Xiong Y,Wei YH,Li F

    更新日期：2018-02-01 00:00:00

  • Biological activities of osteoblasts on poly(methyl methacrylate)/silica hybrid containing calcium salt.

    abstract：:The biological activity of osteoblasts on the newly developed bioactive poly(methyl methacrylate) (PMMA)/silica hybrid containing calcium salt was investigated. The attachment, proliferation, and differentiation of primary cultured mouse calvarial osteoblasts were evaluated by hexosaminase, MTT, and alkaline phosphata...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00421-0

    authors： Rhee SH,Hwang MH,Si HJ,Choi JY

    更新日期：2003-03-01 00:00:00

  • Limiting the protein corona: A successful strategy for in vivo active targeting of anti-HER2 nanobody-functionalized nanostars.

    abstract：:Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively targeting the tumor cells. As this potential has been supported numerously during in vitro experiments, the effective application is hampered by our limited understanding and control of the interactions within complex in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.01.007

    authors： D'Hollander A,Jans H,Velde GV,Verstraete C,Massa S,Devoogdt N,Stakenborg T,Muyldermans S,Lagae L,Himmelreich U

    更新日期：2017-04-01 00:00:00

  • Effect of dual ion implantation of calcium and phosphorus on the properties of titanium.

    abstract：:This study is concerned with the effect of dual implantation of calcium and phosphorus upon the structure, corrosion resistance and biocompatibility of titanium. The ions were implanted in sequence, first Ca and then P, both at a dose of 10(17) ions/cm2 at a beam energy of 25 keV. Transmission electron microscopy was ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.08.015

    authors： Krupa D,Baszkiewicz J,Kozubowski JA,Barcz A,Sobczak JW,Biliński A,Lewandowska-Szumieł M,Rajchel B

    更新日期：2005-06-01 00:00:00

  • Migration of lymphocytes on fibronectin-coated surfaces: temporal evolution of migratory parameters.

    abstract：:Lymphocytes typically interact with implanted biomaterials through adsorbed exogenous proteins. To provide a more complete characterization of these interactions, analysis of lymphocyte migration on adsorbed extracellular matrix proteins must accompany the commonly performed adhesion studies. We report here a comparis...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(99)00154-4

    authors： Bergman AJ,Zygourakis K

    更新日期：1999-12-01 00:00:00

  • The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice.

    abstract：:The development of topical microbicides is a valid approach to protect the genital mucosa from sexually transmitted infections that cannot be contained with effective vaccination, like HSV and HIV infections. A suitable target of microbicides is the interaction between viral proteins and cell surface heparan sulfate p...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.01.055

    authors： Donalisio M,Quaranta P,Chiuppesi F,Pistello M,Cagno V,Cavalli R,Volante M,Bugatti A,Rusnati M,Ranucci E,Ferruti P,Lembo D

    更新日期：2016-04-01 00:00:00

  • Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy.

    abstract：:Reduced expression of autophagy regulators has been observed in pathological cartilage in humans and mice. The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinke...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.12.006

    authors： Chen P,Xia C,Mei S,Wang J,Shan Z,Lin X,Fan S

    更新日期：2016-03-01 00:00:00

  • A neurospheroid network-stamping method for neural transplantation to the brain.

    abstract：:Neural transplantation therapy using neural stem cells has received as potential treatments for neurodegenerative diseases. Indeed, this therapy is thought to be effective for replacement of degenerating neurons in restricted anatomical region. However, because injected neural stem cells integrate randomly into the ho...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.08.008

    authors： Kato-Negishi M,Tsuda Y,Onoe H,Takeuchi S

    更新日期：2010-12-01 00:00:00

  • Synthesis of polylactides with different molecular weights.

    abstract：:The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00076-8

    authors： Hyon SH,Jamshidi K,Ikada Y

    更新日期：1997-11-01 00:00:00

  • Human tissue engineering allows the identification of active miRNA regulators of glioblastoma aggressiveness.

    abstract：:Glioblastoma multiforme (GBM) is among the most aggressive cancers associated with massive infiltration of peritumoral parenchyma by migrating tumor cells. The infiltrative nature of GBM cells, the intratumoral heterogeneity concomitant with redundant signaling pathways likely underlie the inability of conventional an...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.08.009

    authors： Cosset E,Petty T,Dutoit V,Tirefort D,Otten-Hernandez P,Farinelli L,Dietrich PY,Preynat-Seauve O

    更新日期：2016-11-01 00:00:00

  • Switching between self-renewal and lineage commitment of human induced pluripotent stem cells via cell-substrate and cell-cell interactions on a dendrimer-immobilized surface.

    abstract：:Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.03.085

    authors： Kim MH,Kino-oka M

    更新日期：2014-07-01 00:00:00

  • Continuous harvest of stem cells via partial detachment from thermoresponsive nanobrush surfaces.

    abstract：:Stem cell culture is typically based on batch-type culture, which is laborious and expensive. Here, we propose a continuous harvest method for stem cells cultured on thermoresponsive nanobrush surfaces. In this method, stem cells are partially detached from the nanobrush surface by reducing the temperature of the cult...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.10.039

    authors： Peng IC,Yeh CC,Lu YT,Muduli S,Ling QD,Alarfaj AA,Munusamy MA,Kumar SS,Murugan K,Lee HC,Chang Y,Higuchi A

    更新日期：2016-01-01 00:00:00

  • Engineering fibrin matrices: the engagement of polymerization pockets through fibrin knob technology for the delivery and retention of therapeutic proteins.

    abstract：:Engineering extracellular matrices that utilize the body's natural healing capacity enable the progression of regenerative therapies. Fibrin, widely used as a surgical sealant, is one such matrix that may be augmented by the addition of protein factors to promote cell infiltration and differentiation. The thrombin-cat...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.10.060

    authors： Soon AS,Stabenfeldt SE,Brown WE,Barker TH

    更新日期：2010-03-01 00:00:00

  • Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats.

    abstract：:Hyaluronan (HL), a naturally occurring glycosaminoglycan, has been chemically modified through the esterification of its carboxylic groups with different types of alcohol. The physico-chemical properties of these new biopolymers allow the preparation of many biomaterials which may be used in several medical applicatio...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(93)90160-4

    authors： Benedetti L,Cortivo R,Berti T,Berti A,Pea F,Mazzo M,Moras M,Abatangelo G

    更新日期：1993-12-01 00:00:00

  • Optimizing the sterilization of PLGA scaffolds for use in tissue engineering.

    abstract：:There are few suitable techniques available to sterilize biodegradable polyester three-dimensional tissue engineering scaffolds because they are susceptible to degradation and/or morphological degeneration by high temperature and pressure. We used a novel polyllactide-co-glycolide) scaffold (Osteofoam) to determine th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00136-8

    authors： Holy CE,Cheng C,Davies JE,Shoichet MS

    更新日期：2001-01-01 00:00:00

  • Static and dynamic in vitro study of a sol-gel glass bioactivity.

    abstract：:A comparative study of in vitro bioactivity of a sol-gel glass with composition 55% SiO2-41%CaO-4%P2O5 has been carried out by soaking it in a simulated body fluid (SBF) with and without exchange of this solution. When SBF is kept constant (static assay) the solution composition changes, increasing the Ca2+ concentrat...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00419-1

    authors： Rámila A,Vallet-Regí M

    更新日期：2001-08-01 00:00:00

  • The angiogenic potential of three-dimensional open porous synthetic matrix materials.

    abstract：:Angiogenesis is a complex multistage process involving multiple factors and numerous cells. The use of the Chorioallantoic Membrane (CAM) assay is well documented as a method to investigate angiogenesis. This technique is ideal for screening samples, but requires an objective analysis technique. The angiogenic respons...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2007.04.042

    authors： Oates M,Chen R,Duncan M,Hunt JA

    更新日期：2007-09-01 00:00:00

  • The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH.

    abstract：:We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH(2)-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.03.074

    authors： Kim HY,Kim S,Youn H,Chung JK,Shin DH,Lee K

    更新日期：2011-08-01 00:00:00

  • Treating metastatic triple negative breast cancer with CD44/neuropilin dual molecular targets of multifunctional nanoparticles.

    abstract：:Metastasis of cancer makes up the vast majority of cancer-related deaths, and it usually initiates from tumor cells invasiveness and develops through tumor neovasculature. In this work, we have fabricated a CD44/neuropilin dual receptor-targeting nanoparticulate system (tLyP-1-HT NPs) with endogenous or FDA approved c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.05.022

    authors： Liang DS,Zhang WJ,Wang AT,Su HT,Zhong HJ,Qi XR

    更新日期：2017-08-01 00:00:00

  • Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines.

    abstract：:It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.01.010

    authors： Zeng Q,Li H,Jiang H,Yu J,Wang Y,Ke H,Gong T,Zhang Z,Sun X

    更新日期：2017-04-01 00:00:00

  • Histological evaluation of the biocompatibility of a glass-ionomer cement in rat alveolus.

    abstract：:A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(96)00110-x

    authors： Brentegani LG,Bombonato KF,Carvalho TL

    更新日期：1997-01-01 00:00:00

  • Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold.

    abstract：:Tissue engineering combined with gene therapy represents a promising approach for bone regeneration. The Hypoxia-inducible factor-1α (HIF-1α) gene is a pivotal regulator of vascular reactivity and angiogenesis. Our recent study has showed that HIF-1α could promote osteogenesis of bone mesenchymal stem cells (BMSCs) us...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.09.005

    authors： Zou D,Zhang Z,He J,Zhu S,Wang S,Zhang W,Zhou J,Xu Y,Huang Y,Wang Y,Han W,Zhou Y,Wang S,You S,Jiang X,Huang Y

    更新日期：2011-12-01 00:00:00

  • An acellular biologic scaffold does not regenerate appreciable de novo muscle tissue in rat models of volumetric muscle loss injury.

    abstract：:Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem™, a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vas...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.07.040

    authors： Aurora A,Roe JL,Corona BT,Walters TJ

    更新日期：2015-10-01 00:00:00

  • Skeletal repair in rabbits with calcium phosphate cements incorporated phosphorylated chitin.

    abstract：:The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00205-3

    authors： Wang X,Ma J,Feng Q,Cui F

    更新日期：2002-12-01 00:00:00

  • Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.

    abstract：:Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and size, and controlled release of immune-modulators. As thes...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.11.038

    authors： Kosmides AK,Meyer RA,Hickey JW,Aje K,Cheung KN,Green JJ,Schneck JP

    更新日期：2017-02-01 00:00:00