Cyclic AMP can partially restore platelet-derived growth factor-stimulated prostaglandin E2 biosynthesis, and calcium mobilization in EJ-ras-transformed NIH-3T3 cells.

abstract：:Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an endochondral process and marrow ablation that proceeds by only an in...

journal_title：Journal of cellular physiology

authors： Wigner NA,Soung do Y,Einhorn TA,Drissi H,Gerstenfeld LC

更新日期：2013-11-01 00:00:00

abstract：:The enzyme alkaline phosphatase (AP) has been shown to be lost or inappropriately expressed during carcinogenesis in some tissues. Because retinoic acid (RA) appears to play a role in the normal regulation of the enzyme (RA up-regulates AP in a variety of cell types) we have suggested that altered AP expression in som...

journal_title：Journal of cellular physiology

authors： Reese DH,Larsen RA,Hornicek FJ

更新日期：1992-05-01 00:00:00

abstract：:An efficient regulation of fuel metabolism in response to internal and environmental stimuli is a vital task that requires an intact carnitine system. The carnitine system, comprehensive of carnitine, its derivatives, and proteins involved in its transformation and transport, is indispensable for glucose and lipid met...

journal_title：Journal of cellular physiology

authors： Peluso G,Nicolai R,Reda E,Benatti P,Barbarisi A,Calvani M

更新日期：2000-03-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, al...

journal_title：Journal of cellular physiology

authors： Xu CP,Sun HT,Yang YJ,Cui Z,Wang J,Yu B,Wang FZ,Yang QP,Qi Y

更新日期：2019-08-01 00:00:00

abstract：:HCF-1 functions as a coactivator for herpes simplex virus VP16 and a number of mammalian transcription factors. Mature HCF-1 is composed of two subunits generated by proteolytic cleavage of a larger precursor at six centrally-located HCF(PRO) repeats. The resulting N- and C-terminal subunits remain tightly associated ...

journal_title：Journal of cellular physiology

authors： Mahajan SS,Johnson KM,Wilson AC

更新日期：2003-02-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00

abstract：:The signal transducer and activator of transcription (Stat5) funnels extracellular signals of cytokines, hormones, and growth factors into transcriptional activity in the mammary gland. Postnatal development and functionality of this tissue is synchronized with the reproductive cycle. Consequently, Stat5 involvement i...

journal_title：Journal of cellular physiology

authors： Barash I

更新日期：2006-11-01 00:00:00

abstract：:Low-grade chronic inflammation is a salient feature of obesity and many associated disorders. This condition frequently occurs in central obesity and is connected to alterations of the visceral adipose tissue (AT) microenvironment. Understanding how obesity is related to inflammation may allow the development of thera...

journal_title：Journal of cellular physiology

authors： Petrangeli E,Coroniti G,Brini AT,de Girolamo L,Stanco D,Niada S,Silecchia G,Morgante E,Lubrano C,Russo MA,Salvatori L

更新日期：2016-03-01 00:00:00

abstract：:Intermediate subviral particles (ISVP) derived from reovirus represent a simple model system for the switch-on of transcriptase function. In such particles the endogenous transcriptase is present in a switched-off form, one step removed from the switched-on state. Switch-on of transcriptase function is an active proce...

journal_title：Journal of cellular physiology

authors： Borsa J,Sargent MD,Ewing DD,Einspenner M

更新日期：1982-07-01 00:00:00

abstract：:Control of the terminal event in cellular differentiation is an important normal regulatory process, and the expression of defects in the control of this process has been implicated in the pathogenesis of cancer. To determine if tumor necrosis factor (TNF), which is an important biological response modifier, can inhib...

journal_title：Journal of cellular physiology

authors： Filipak M,Sparks RL,Tzen CY,Scott RE

更新日期：1988-11-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumorigenesis. lncRNA LINC01561 (LINC01561) is a newly identified tumor-related lncRNA and its dysregulation has been demonstrated in several tumors. However, whether LINC01561 is involved in the progression of non-small-cell lung carci...

journal_title：Journal of cellular physiology

authors： Gao W,Qi CQ,Feng MG,Yang P,Liu L,Sun SH

更新日期：2020-10-01 00:00:00

abstract：:Dermal fibroblasts exposed to low oxygen tension show upregulated synthesis of transforming growth factor-beta 1 (TGF-beta 1), an established stimulatory peptide in the formation of extracellular matrix proteins. In this report, procollagen synthesis was measured in cultures of confluent adult human dermal fibroblasts...

journal_title：Journal of cellular physiology

authors： Falanga V,Martin TA,Takagi H,Kirsner RS,Helfman T,Pardes J,Ochoa MS

更新日期：1993-11-01 00:00:00

abstract：:Vole cells transformed by avian sarcoma virus carrying the src gene lose their fibroblastic morphology, the organized cytoskeletal system of the normal fibroblastic cell, the typical fibronectin deposit around the cell membrane, and the ability to shut off multiplication when suspended in liquid medium. All of these t...

journal_title：Journal of cellular physiology

authors： Puck TT,Erikson RL,Meek WD,Nielson SE

更新日期：1981-06-01 00:00:00

abstract：:Elevated levels of follistatin-like protein 1 (FSTL1) have been found both in mouse models for human rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). In this study, we elucidated the potential mechanisms by which FSTL1 contributes to the pathogenesis of RA. Fibroblast-like synoviocytes (FLSs) were estab...

journal_title：Journal of cellular physiology

authors： Ni S,Li C,Xu N,Liu X,Wang W,Chen W,Wang Y,van Wijnen AJ

更新日期：2018-01-01 00:00:00

abstract：:The molecular weight of rat basic fibroblast growth factor is predicted to be 18 kDa when the amino acid sequence is read from the single AUG initiation codon found in the cDNA. DNA sequencing upstream of this AUG codon indicated, however, that there was an extended open reading frame. In vitro translation of the rat ...

journal_title：Journal of cellular physiology

authors： Powell PP,Klagsbrun M

更新日期：1991-08-01 00:00:00

abstract：:The release of superoxide anion (O2-) by inflammatory macrophages, multinucleated giant cells, and epithelioid cells, obtained by the insertion of round glass coverslips into the subcutaneous tissue of mice, was investigated. O2- was shown to be spontaneously released by cells on the surface of glass coverslips implan...

journal_title：Journal of cellular physiology

authors： Camarero VC,Junqueira VB,Colepicolo P,Karnovsky ML,Mariano M

更新日期：1990-12-01 00:00:00

abstract：:Hepatic expression of the protooncogenes c-fos and c-myc occurs within 2 h after partial hepatectomy, and these immediate early genes are thought to prime the hepatocytes for subsequent proliferation. To examine whether such gene activation occurred in the setting of hepatocyte proliferation after toxic liver injury, ...

journal_title：Journal of cellular physiology

authors： Schmiedeberg P,Biempica L,Czaja MJ

更新日期：1993-02-01 00:00:00

abstract：:Shear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress-related tensional forces might be associated with pathophysiological susceptibility, a more comprehensive molecular map needs to be addressed. Thus, we subjected human umbilical vein endothelial cel...

journal_title：Journal of cellular physiology

authors： Pinto TS,Fernandes CJDC,da Silva RA,Gomes AM,Vieira JCS,Padilha PM,Zambuzzi WF

更新日期：2019-07-01 00:00:00

abstract：:Insulin gene expression in rat insulinoma (RIN) cells is extinct in RIN x fibroblast hybrids and can reappear upon loss of DNA contributed by the fibroblast parent. (Besnard et al., Exp. Cell Res. 185:101-108, 1989). In the present study, we looked for the role of 5'-flanking sequences of the human insulin gene in the...

journal_title：Journal of cellular physiology

authors： Besnard C,Monthioux E,Loràs P,Jami J,Daegelen D

更新日期：1991-03-01 00:00:00

abstract：:Optimal stimulation of signal transduction and biological functions by IGF-I in porcine smooth muscle cells (pSMC) requires ligand occupancy of the alphaVbeta3 integrin. Binding of heparin-binding domain (HBD) of vitronectin (VN) to the cysteine loop (C-loop) region of beta3 is required for pSMC to respond optimally t...

journal_title：Journal of cellular physiology

authors： Xi G,Maile LA,Yoo SE,Clemmons DR

更新日期：2008-02-01 00:00:00

abstract：:The correspondence between K+ uptake in platelets to their responsiveness was studied using 86Rb+ as an analogue of K+. An average 86Rb+ uptake rate of 0.73 (+/- 0.140) x 10(-15) mole Rb+/min-plt (n = 20) was observed. By the use of K(+)-influx inhibitors, we were able to distinguish three distinct 86Rb+ uptake pathwa...

journal_title：Journal of cellular physiology

authors： Marx G,Blankenfeld A,Panet R,Gorodetsky R

更新日期：1992-05-01 00:00:00

abstract：:A new system for studying growth of normal human mammary epithelial cells in an in vivo environment using athymic nude mice is described. Human mammary epithelial cells dissociated from reduction mammoplasty specimens were embedded within collagen gels and subsequently transplanted subcutaneously into nude mice. Histo...

journal_title：Journal of cellular physiology

authors： Popnikolov NK,Yang J,Guzman RC,Swanson SM,Thordarson G,Collins G,Talamantes F,Nandi S

更新日期：1995-04-01 00:00:00

abstract：:Normal human keratinocytes (NHK) were cultured in serum-free medium, containing low (0.1 mM) or high (2 mM) calcium, to obtain proliferating and differentiating cultures, respectively. Proteoglycan (PG) synthesis of proliferating and differentiating NHK was investigated. Cultures were labeled with 35S-sulfate, and the...

journal_title：Journal of cellular physiology

authors： Rahemtulla F,Moorer CM,Wille JJ Jr

更新日期：1989-07-01 00:00:00

abstract：:DEAH box protein DHX33 has been found to be necessary for cell proliferation and early development of multicellular organisms. It plays diverse roles in regulating gene transcription, ribosome RNA synthesis, and protein translation. Dysregulation of DHX33 has been observed in various human cancers. In this study, we i...

journal_title：Journal of cellular physiology

authors： Su D,Yuan B,Su C,Zhang Y

更新日期：2019-01-26 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common cancers and the fifth most common reason for cancer deaths in the males. Surgical castration combined with androgen deprivation therapy, antiandrogens, and androgen synthesis inhibitors is the current therapeutic modalities for PCa. These strategies inhibit androgen synt...

journal_title：Journal of cellular physiology

authors： Rezaei S,Mahjoubin Tehran M,Sahebkar A,Jalili A,Aghaee-Bakhtiari SH

更新日期：2020-04-01 00:00:00

abstract：:Using a serum-free system, we have investigated the influence of human fibronectin (HFN) and selected growth factors (GF) on the attachment and growth of normal human keratinocytes in vitro. Single-cell suspensions of keratinocytes from near-confluent primary plates, plated on 5-10 microgram/cm2 HFN, showed approximat...

journal_title：Journal of cellular physiology

authors： Gilchrest BA,Calhoun JK,Maciag T

更新日期：1982-08-01 00:00:00

abstract：:Serum stimulation of quiescent 3T3 cells returns the cells to a proliferative state. Changes in Ca content, transport and distribution during the transition through G1 and S phase have been investigated following serum stimulation of these cells. 45 Ca exchange data indicate at least two kinetically defined cellular c...

journal_title：Journal of cellular physiology

authors： Tupper JT,Del Rosso M,Hazelton B,Zorgniotti F

更新日期：1978-04-01 00:00:00

abstract：:Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and immune cells in tumor microenvironment to suppress anti-tumor responses. Two cell surface expressed ...

journal_title：Journal of cellular physiology

authors： Kazemi MH,Raoofi Mohseni S,Hojjat-Farsangi M,Anvari E,Ghalamfarsa G,Mohammadi H,Jadidi-Niaragh F

更新日期：2018-03-01 00:00:00

abstract：:Infection with Verotoxin producing Escherichia coli (VTEC) has been implicated in hemolytic uremic syndrome, the leading cause of pediatric renal failure. Verotoxin (VT) binds to globotriaosylceramide (Gal alpha 1-4Gal beta 1-4GlcCer Gb3) in susceptible cells. Gb3 is required for cytotoxicity and toxin-resistant cells...

journal_title：Journal of cellular physiology

authors： Pudymaitis A,Lingwood CA

更新日期：1992-03-01 00:00:00

abstract：:The cell surface phenotype of pluripotent hemopoietic stem cells (CFU-S) and committed progenitors (CFU-C1, CFU-C2, BFU-E) of mouse bone marrow was analyzed with respect to their binding of wheat germ agglutinin (WGA) and two monoclonal antibodies, anti-GM-1.2 and anti-PGP-1. Stained cells were fractionated on the bas...

journal_title：Journal of cellular physiology

authors： Bauman JG,Wagemaker G,Visser JW

更新日期：1986-07-01 00:00:00