Abstract:
AIM:The aim of this study was to determine the expression levels of serum ferritin (SF) and investigate the correlation between SF expression levels and clinical characteristics as well as the efficacy to platinum-based chemotherapy for advanced non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS:Electrochemiluminescence method was used to determine the expression levels of SF in the peripheral blood of 46 advanced NSCLC patients and 63 healthy subjects. RESULTS:The expression levels of SF in healthy subjects were significantly lower than those in patients with advanced NSCLC patients (t = -3.279,P = 0.001). There was a statistically significant difference between SF expression levels and distant metastasis, regional lymph node metastasis, respectively (P < 0.05). However, there was no correlation between SF expression levels and sex, age, eastern cooperative oncology group performance status, smoking history, pathological type, tumor location and tumor-node-metastasis stage (All P > 0.05). The overall response rate to platinum-based chemotherapy was 57.1% (12/21) in normal SF expression levels group, which was significantly higher than that was 28% (7/25) in high SF expression levels group (χ² = 3.998,P = 0.046). CONCLUSIONS:SF may be a valuable blood marker for predicting the tumor progression and the efficacy of platinum-based therapies for advanced NSCLC patients.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Shi HB,Li XD,Jiang JT,Zhao WQ,Ji M,Wu CPdoi
10.4103/0973-1482.139156subject
Has Abstractpub_date
2014-07-01 00:00:00pages
681-5issue
3eissn
0973-1482issn
1998-4138pii
JCanResTher_2014_10_3_681_139156journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Synovial sarcoma (SS) is a rare disease and compared with other soft-tissue sarcomas has a relatively high mortality rate. The optimal management of this disease and prognostic factors associated with patient outcome remains controversial. AIMS:We aimed to evaluate the factors affecting the outcomes of SS p...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,多中心研究
doi:10.4103/0973-1482.131381
更新日期:2014-01-01 00:00:00
abstract:Objective:The objective of this study is to evaluate health literacy level, cervical cancer knowledge, and practice among women patients undergoing screening. Materials and Methods:A cross-sectional study was conducted among 455 women family health center patients. Health literacy level was evaluated by Rapid Estimate...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_1142_16
更新日期:2019-10-01 00:00:00
abstract:CONTEXT:Toxoplasma gondii is a protozoan parasite with a world-wide distribution. However, the majority of infected cases remain symptomless. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. The inhibitory effect of T. gondii on canc...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.144638
更新日期:2015-04-01 00:00:00
abstract::We report a known case of adenoid cystic carcinoma of right parotid gland in a 36-year-old Indian male, diagnosed 5 years ago for which he underwent surgery followed by radiotherapy. Now the patient has presented to the surgical oncologist with a mass near angle of right jaw. Computed tomography (CT) performed elsewhe...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.110374
更新日期:2013-01-01 00:00:00
abstract:Aim of Study:To examine the function of lenalidomide (LEN) on the human multidrug resistance (MDR)-type gastric cancer line SGC7901/vincristine (VCR) via regulating Notch signaling. Materials and Methods:Quantitative polymerase chain reaction was used for checking the genes of Notch, DNA methyltransferase (DNMT), RBP-...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.183181
更新日期:2018-01-01 00:00:00
abstract::Multiple enlarged lymph nodes in an elderly female patient can have varied etiologies as well as histologic pictures. We are presenting the case of a 53-year-old female who presented with inguinal lymphadenopathy with fever, which was clinically misconstrued as lymphoma. Cytology could not exclude a lymphoma. Histolog...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.147714
更新日期:2015-07-01 00:00:00
abstract:Aims:This study is carried out to report on the knowledge and practice regarding breast self-examination (BSE) among women from the city of Mosul in Iraq and to evaluate the prevalence of performing clinical breast examination (CBE) and mammography among them. Settings and Design:A descriptive, cross-sectional survey ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_736_19
更新日期:2020-10-01 00:00:00
abstract:CONTEXT:The compound 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) has been isolated from several different plant species, including Petroselinum sativum. Our recent study found that apiole is a chemical derivative of 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1), which has been isolated from dried Antrodi...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.106529
更新日期:2012-10-01 00:00:00
abstract:Purpose:Programmed death ligand-1 (PD-L1) is the main ligand for programmed death-1 (PD-1), and is one of the major targets for cancer immunotherapy. Only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). There is a controversial association between PD-L1 express...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_759_19
更新日期:2020-12-01 00:00:00
abstract:Aim of Study:Association of toll-like receptors (TLRs) with the risk of oral squamous cell carcinoma (OSCC) from the published reports is still conflicting. This study was conducted to evaluate the relationship between TLRs and the risk of OSCC using meta-analysis method. Materials and Methods:The association studies ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,meta分析
doi:10.4103/0973-1482.163789
更新日期:2018-01-01 00:00:00
abstract:AIMS:Few studies have examined the clinical characteristics of patients with brain metastases from small-cell esophageal cancer. In this study, we review the clinical characteristics and outcomes in patients with brain metastases from small-cell esophageal cancer. PATIENTS AND METHODS:From August 2002 to August 2012, ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.151469
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Lung cancer is the leading cause of cancer-related death worldwide, and the number of elderly patients with nonsmall-cell lung cancer (NSCLC) has risen with increasing life-expectancy. AIMS:To evaluate safety and efficacy of thoracoscopic lobectomy for NSCLC patients above 75 years old. PATIENTS AND METHOD...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.140930
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Isolated primary pancreatic lymphoma (PPL) is a rare extra-lymphatic non-Hodgkin's lymphoma comprising less than 1% of all extra-lymphatic lymphomas. It is seen in people of advanced age and there is a slight male preponderance. It is difficult to diagnose; the vague presenting symptoms and nonspecific labor...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.39000
更新日期:2007-10-01 00:00:00
abstract::Rectal cancers may rarely metastasize in bone and when it occurs, is usually preceded by lung and/or liver metastasis. However, whether it may ever bypasses other organs, particularly lung and liver and metastasizes directly to bone or not, is debatable. Some authors have described the presence of isolated bone metast...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.136675
更新日期:2014-04-01 00:00:00
abstract:Aim:The aims of this study are to evaluate the serum levels of paraoxonase (PON) and arylesterase (ARE) in breast cancer (BC) patients; to determine their relationship with chemotherapy requirements in BC; and to find a cut-off value to assess subjects with a higher risk of BC. Subjects and Methods:A total of 40 BC pa...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.235355
更新日期:2018-06-01 00:00:00
abstract::Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.144360
更新日期:2015-07-01 00:00:00
abstract:Purpose:Papillary thyroid carcinoma (PTC) has a strong propensity to metastasize to regional lymph nodes which increases the risk of local-regional relapse and affects the course of the disease. Molecular pathogenesis of lymph node metastasis (LNM) is not yet fully understood. Survivin, a multifunctionale molecule invo...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.163675
更新日期:2018-01-01 00:00:00
abstract:AIM OF STUDY:The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity. MATERIALS AND METHODS:Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.151931
更新日期:2016-04-01 00:00:00
abstract:Background:We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome. Methods:We investigated 181 paraffin-embedded B-cell lymphoma samples usin...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_243_18
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Adenoid cystic carcinoma (ACC) is malignant neoplasm of the salivary glands. It accounts for most cases of minor salivary gland malignancies and a substantial proportion of parotid and submandibular gland malignancies. ACC is associated with a high mortality rate, and it often recurs after prolonged period...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.177504
更新日期:2016-04-01 00:00:00
abstract::Medullary thyroid carcinoma is a rare thyroid neoplasm that can be either sporadic or familial. It occurs in adults, presenting as a solitary cold nodule on thyroid scan. Most are solid, firm, and non-encapsulated, and occur in the mid portion or upper half of the thyroid gland, corresponding to areas with greater num...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.82916
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate inter and intraobserver concordance in gross tumor volume (GTV) delineation on megavoltage CT (MVCT) images in patients with postoperative vault recurrences. MATERIALS AND METHODS:Three observers delineated GTV on MVCT and CECT and two observers recontoured on MVCT images. T...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.87022
更新日期:2011-07-01 00:00:00
abstract::Adjuvant treatment options for Stage I seminoma include active surveillance, chemotherapy, and radiotherapy. Active surveillance may not be ideal for the average Indian patient. Of the two accepted adjuvant therapy options, namely single-dose carboplatin chemotherapy and radiotherapy to the retroperitoneal nodes, thou...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章,评审
doi:10.4103/0973-1482.176171
更新日期:2016-10-01 00:00:00
abstract::Primary mucinous epithelial tumors of the testis are extremely rare. Although isolated case reports and small series have been published, these interesting neoplasms are less well-known. We report a case of a primary intratesticular mucinous cystadenoma in an asymptomatic 44-year-old man. Right radical orchiectomy was...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.143363
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Malignant fibrous histiocytoma (MFH) is an uncommon neoplasm of maxillary sinus. This study was designed to investigate the clinical courses and summarize the experience of the treatment outcomes. MATERIALS AND METHODS:This is a retrospective analysis which included patients with MFH of the maxillary sinus ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_29_17
更新日期:2017-01-01 00:00:00
abstract:AIM:This study was aimed to assess the in vivo anti-tumoral potency of the novel 6-nitro-2-(3-chloropropyl)-1H-benz[de]isoquinoline-1,3-dione [Compound 1] that has earlier demonstrated excellent cytotoxicity in 15 out of 17 human tumor cell lines tested. MATERIALS AND METHODS:Two murine tumors namely Sarcoma-180 (S-18...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.119332
更新日期:2013-07-01 00:00:00
abstract::Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and un...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.204889
更新日期:2018-12-01 00:00:00
abstract:Background:Squamous cell carcinoma (SCC) of the breast is an extremely rare tumor with vague natural behavior and treatment. The purpose of this study was to identify the clinicopathological features and treatment results of this rare type of breast cancer. Materials and Methods:The medical files of patients with SCC ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/jcrt.JCRT_303_17
更新日期:2019-07-01 00:00:00
abstract::Basal cell adenoma (BCA) of the salivary glands is an uncommon type of monomorphic adenoma which constitutes 1% of all salivary gland tumors. It most commonly involves parotid gland, while it rarely occurs in minor salivary glands. Upper lip, buccal mucosa, and lower lip are the common intraoral sites; whereas, palate...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件
doi:10.4103/0973-1482.147391
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Our experience with endoscopic surgery for vascular leiomyomas of the nasal septum was reviewed. PATIENTS AND METHODS:All patients with vascular leiomyomas of the nasal septum who were treated with endoscopic surgery from May 1995 to June 2007 were reviewed retrospectively. RESULTS:Twelve patients had vascu...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.150417
更新日期:2016-01-01 00:00:00