Abstract:
OBJECTIVES:To identify biomarkers for neuronal injury and outcome in perinatal asphyxia. METHODS:This prospective cohort study was done in authors' level III NICU involving 80 neonates - 40 babies with perinatal asphyxia and 40 weight and gender matched normal neonates. Levels of cytokines IL-6, IL -1β, IL-2 and TNF -α in cord blood of these neonates were estimated and correlated with the severity of asphyxia and developmental outcome at 6 mo using Baroda Developmental Score. RESULTS:The baseline parameters revealed that there was no statistically significant difference between the two groups in terms of maternal age, parity, gestational age, gender and birth weight. The levels of cytokines IL-6 (p < 0.001) and IL-1beta (p < 0.03) were significantly higher in babies with perinatal asphyxia and correlated with the severity of asphyxia. The levels of IL-6 and IL-1β had significant negative correlation with developmental score at 6 mo. A cut off level of 14.18 pg/ml for IL-6 had 92.3 % sensitivity and 57.7 % specificity [Area under the curve = 0.80 (0.62-0.84)] for adverse neuro-developmental outcome while it was 11.17 pg/ml for IL-1β with a sensitivity of 69.2 % and specificity of 71.2 % [Area under the curve = 0.67 (0.57-0.80)]. CONCLUSIONS:IL-6 and IL-1 β are good predictive markers of severity of asphyxia and adverse neurological outcome.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Bharathi B,Bhat BV,Negi VS,Adhisivam Bdoi
10.1007/s12098-014-1575-4subject
Has Abstractpub_date
2015-05-01 00:00:00pages
433-8issue
5eissn
0019-5456issn
0973-7693journal_volume
82pub_type
杂志文章abstract::Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). Despite medical advances, growth failure and hypogonadism remain significant clinical problems in these patients in adolescence. Disproportionate truncal shortening which is common especially among ad...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02760702
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of early onset Group B Streptococcal (GBS) infection in infants born over a two year period and to determine the outcome of sepsis evaluation in infants born to mothers with GBS colonization. METHODS:The charts of infants born to mothers with GBS colonization were reviewed for deta...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Indian journal of pediatrics
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更新日期:2010-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-2822-x
更新日期:2019-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type:
doi:10.1007/s12098-008-0025-6
更新日期:2008-02-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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journal_title:Indian journal of pediatrics
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02759903
更新日期:2006-06-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02758174
更新日期:2000-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
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更新日期:2004-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02723198
更新日期:2001-03-01 00:00:00