The importance of homozygous polymorphisms of methylenetetrahydrofolate reductase gene in romanian patients with idiopathic venous thromboembolism.

Abstract:

BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. AIMS:We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic venous thromboembolism (VTE) in a Romanian population and the associated risk of VTE. STUDY DESIGN:We performed a case-control transversal study including 90 patients diagnosed with VTE and 75 sex- and age-matched controls. METHODS:MTHFR C677T and A1298C polymorphisms were detected using PCR-RFLP method. RESULTS:The homozygous MTHFR 677TT genotype, present in 18.8% of patients with VTE versus 6.6% of controls, was significantly associated with VTE (p= 0.021, OR= 3.26, 95%CI (1.141-9.313)). The heterozygous MTHFR A1298C genotype, presenting the highest prevalence in the VTE group (34.4%) as well as in controls (37.3%), was not associated with VTE (p=0.7). No associations were found for heterozygous MTHFR C677T (with a frequency of 32.2% in VTE and 37.3% in controls, p=0.492), respective homozygous MTHFR A1298C genotype (with a frequency of 1.1% in VTE and 2.6% in controls, p=0.456). CONCLUSION:Among MTHFR polymorphisms, only homozygosity for MTHFR 677TT may be considered a risk factor for VTE; the MTHFR A1298C polymorphism is not significantly associated with an increased risk of VTE.

journal_name

Balkan Med J

journal_title

Balkan medical journal

authors

Hotoleanu C,Trifa A,Popp R,Fodor D

doi

10.5152/balkanmedj.2013.7159

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

197-203

issue

2

eissn

2146-3123

issn

2146-3131

pii

bmj-30-2-197

journal_volume

30

pub_type

杂志文章
  • Multiple occipital, parietal, temporal, and frontal foramina: a variant of enlarged parietal foramina in an infant.

    abstract:BACKGROUND:Calvarial lesions are often detected incidentally in routine radiology. Most lytic lesions of the skull are benign. Enlarged parietal foramina are benign lesions caused by deficient intramembranous ossification. CASE REPORT:An 11 month-old female patient was admitted with a mass on the right of the back of ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.14528

    authors: Yılmaz E,Yetim A,Erol OB,Pekcan M,Yekeler E

    更新日期:2014-12-01 00:00:00

  • Balanced chromosomal translocation of chromosomes 6 and 7: a rare male factor of spontaneous abortions.

    abstract:BACKGROUND:Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. CASE REPORT:We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.107

    authors: Resim S,Kadıoğlu A,Akman T,Bayrak AG,Efe E

    更新日期:2013-06-01 00:00:00

  • Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats.

    abstract:BACKGROUND:The increases of free radicals have been proposed to be involved in the pathogenesis of sepsis, which leads to multiple-organ dysfunction syndromes. The uses of antioxidants as a complementary tool in the medical care of oxidative stress-related diseases have attracted attention of researchers. Resveratrol (...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.15516

    authors: Aydın S,Şahin TT,Bacanlı M,Taner G,Başaran AA,Aydın M,Başaran N

    更新日期:2016-11-01 00:00:00

  • Comparison of Scoring Systems in Predicting Success of Percutaneous Nephrolithotomy

    abstract:Background:Scoring systems are useful to inform the patients about the success and complication rates of the operation prior the surgery. Aims:To determine the applicability of the popular scoring systems (Guy’s, stone size, tract length, obstruction, number of involved calices, and essence/stone density and Clinical ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.1631

    authors: Akçay M,Tosun M,Gevher F,Kalkan S,Ersöz C,Kayalı Y,Tepeler A

    更新日期:2019-01-01 00:00:00

  • Fetal Oropharyngeal and Neck Tumors: Determination of the Need for Ex-Utero Intrapartum Treatment Procedure.

    abstract:BACKGROUND:The aim of this study was to assess the ex-utero intrapartum therapy (EXIT) applied to 3 of the 7 cases with oropharyngeal or neck masses and review the indicators of the need for an EXIT procedure. CASE REPORT:Prenatal presentation, size and localization of the masses, existence of fetal hydrops and associ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.150096

    authors: Özgünen FT,Güleç ÜK,Evrüke İC,Demir SC,Büyükkurt S,Yapıcıoğlu H,İskit S

    更新日期:2015-04-01 00:00:00

  • Outcomes after transhiatal esophagectomies in an eastern-European low-volume center.

    abstract:BACKGROUND:The present study proposes to analyze the results obtained after transhiatal esophagectomies (THE), from the perspective of an Eastern European surgical center with low esophageal resection volume (LV). AIMS:Our analysis, which to the authors' knowledge is the first of its kind in Romania, has the purpose o...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15514

    authors: Neagoe R,Voidazan S,Szocs M,Sala DT,Bancu S,Mulhfay G

    更新日期:2015-01-01 00:00:00

  • Primary culture of choroid plexuses from neonate rats containing progenitor cells capable of differentiation.

    abstract:BACKGROUND:The choroid plexuses, which could secrete a number of neurotrophins, have recently been used in transplantation in central nervous system diseases. AIMS:To study the mechanism of nerve regeneration in the central nervous system by grafting choroid plexus tissues. STUDY DESIGN:Animal experimentation. METHO...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2013.8259

    authors: Huang SL,He XJ,Li ZF,Yao L,Yuan GL,Shi W

    更新日期:2013-12-01 00:00:00

  • Amyopathic Dermatomyositis Associated with Histopathological Findings of Organizing Pneumonia and Pulmonary Vasculitis.

    abstract:BACKGROUND:Clinically, amyopathic dermatomyositis is a clinically distinct subgroup of dermatomyositis characterised by unique dermatological manifestations without muscle involvement. Clinically, amyopathic dermatomyositis is frequently associated with interstitial lung disease, which usually has a rapidly progressive...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.1061

    authors: Lim JU,Kang HS,Kim YH,Kim TJ

    更新日期:2017-08-04 00:00:00

  • The effects of tramadol and levobupivacaine infiltration on postoperative analgesia in functional endoscopic sinus surgery and septorhinoplasty.

    abstract:OBJECTIVE:The aim of this prospective, randomized, double-blind study was to investigate the postoperative analgesic effects of levobupivacaine or tramadol infiltration administered prior to surgery in septorhinoplasty (SRP) or endoscopic sinus surgery (ESS). MATERIAL AND METHODS:Sixty ASA class I-III adult patients e...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.027

    authors: Koputan MH,Apan A,Oz G,Köse EA

    更新日期:2012-12-01 00:00:00

  • Comparison of Single and Prolonged Fluoroquinolone Prophylaxis and Risk Factors for Infectious Complications After Transrectal Prostate Biopsy

    abstract:Background:The ideal prophylaxis duration for transrectal ultrasonography-guided prostate biopsy is incompletely defined. Aims:To compare the infectious complications of transrectal ultrasonography-guided prostate biopsy with and without extended antibiotic prophylaxis. The secondary aim was to evaluate the risk facto...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2018.0477

    authors: Kalkanlı A,Gezmiş CT,Özkan A,Çilesiz NC,Yanaral F,Aydın M,Tandoğdu Z

    更新日期:2018-09-21 00:00:00

  • Effects of intrathecal carbenoxolone treatment on nociception and analgesia in rat.

    abstract:BACKGROUND:Gap junctions (GJ) are important in pain signalling at the spinal cord level. AIMS:The aim of this investigation was to study the effects of GJ on nociception and the analgesic/hyperalgesic effects of morphine following administration of carbenoxolone as a GJ blocker. Male Wistar rats (200-250 g) were divid...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.13099

    authors: Kamalpour M,Fereidoni M,Moghimi A

    更新日期:2014-06-01 00:00:00

  • General or local anaesthesia in one-day thyroid surgery-does it matter?

    abstract:OBJECTIVE:We aimed to determine the safety and feasibility of general anaesthesia (GA) compared with local anaesthesia + Monitored Anaesthesia Care (LA+MAC) for One-Day Thyroid Surgery (ODTS); to assess patient and operator satisfaction with either of the anesthetic approaches. MATERIAL AND METHODS:We reviewed prospec...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.006

    authors: Belitova M,Pandev R,Karadimov D

    更新日期:2012-06-01 00:00:00

  • Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting.

    abstract:BACKGROUND:Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS:To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.0012

    authors: Kaya AH,Tekgündüz E,Duygu F,Koca D,Bekdemir F,Batgi H,Ulu Uncu B,Yiğenoğlu TN,Dal MS,Çakar Kızıl M,Altuntaş F

    更新日期:2017-04-05 00:00:00

  • Negative pressure wound therapy and skin graft in madura foot treatment.

    abstract::Madura foot is a rare, loca, chronic granulomatous skin infection which commonly affects the adult male foot. Medical treatment reduces the size of the lesion but surgical excision is necessary for radical treatment. We present a case of a 59 year old male farmer diagnosed as actinomadura of the right foot treated wit...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.014

    authors: Kalender AM,Baykan H,Ozkan F,Cıralık H,Oztürk P,Gül M,Uçmak H

    更新日期:2012-06-01 00:00:00

  • Favorable Outcome with Close Margins in Patients Undergoing Nipple/Skin Sparing Mastectomy with Immediate Breast Reconstruction: 5-year Follow-up.

    abstract:BACKGROUND:Implant-based breast reconstruction after mastectomy has recently been reported to be the preferred type of surgery among breast-specific surgeons and plastic surgeons. AIMS:To explore the significant clinicopathological factors associated with long-term outcome related to local recurrences of the nipple am...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.0029

    authors: Özkurt E,Tükenmez M,Güven E,Çelet Özden B,Öner G,Müslümanoğlu M,İğci A,Özmen V,Küçücük S,Cabioğlu N

    更新日期:2018-01-20 00:00:00

  • Retroauricular Approach for Targeted Cochlear Therapy Experiments in Wistar Albino Rats.

    abstract:BACKGROUND:As the idea of stem cell technology in the treatment of sensorial hearing loss has emerged over the past decades, the need for in vivo models for related experiments has become explicit. One of the most common experimental models for inner ear stem cell delivery experiments is the Wistar albino rat. AIMS:To...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.0226

    authors: Mülazımoğlu S,Ocak E,Kaygusuz G,Gökcan MK

    更新日期:2017-05-05 00:00:00

  • Does Short Message Service Increase Adherence to Smoking Cessation Clinic Appointments and Quitting Smoking?

    abstract:BACKGROUND:Using innovative and scientific methods increases the rate of quitting in smokers. Short message service (SMS) is a communication tool widely used and well integrated in many people's daily lives. To increase adherence to appointments in smoking cessation clinics (SCC), it is thought that increased complianc...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.151610

    authors: Önür ST,Uysal MA,İliaz S,Yurt S,Bahadır A,Hattatoğlu DG,Ortaköylü MG,Bağcı BA,Chousein EG

    更新日期:2016-09-01 00:00:00

  • Matrix Metalloproteinase-9 Level and Gene Polymorphism in Sleep Disordered Breathing Patients with or without Cardiovascular Disorders.

    abstract:OBJECTIVE:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the matrix metalloproteinase-9 (MMP-9) level and MMP-9 gene polymorphism in sleep apnea patients with or without cardiovascular disease. STUDY DESIGN:Case-control study. MATER...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.068

    authors: Yüksel M,Kuzu-Okur H,Velioğlu-Öğünç A,Pelin Z

    更新日期:2013-03-01 00:00:00

  • Cortisol and Hippocampal Volume as Predictors of Active Suicidal Behavior in Major Depressive Disorder: Case Report.

    abstract:BACKGROUND:Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the inter...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.150842

    authors: Moica T,Grecu IG,Moica S,Grecu MG,Buicu GE

    更新日期:2016-11-01 00:00:00

  • Definitive radiotherapy in locally advanced non-small cell lung cancer: dose and fractionation.

    abstract::Definitive radiotherapy plays a major role in the treatment of locally advanced non-small cell lung cancer (LA NSCLC). After the impact of RT dose for lung cancer was established, a number of trials were structured with the aim of better local control and overall survival by either dose escalation or shortening the to...

    journal_title:Balkan medical journal

    pub_type: 杂志文章,评审

    doi:10.5152/balkanmedj.2014.14496

    authors: Dağoğlu N,Karaman Ş,Arifoğlu A,Küçücük S,Oral EN

    更新日期:2014-12-01 00:00:00

  • New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio.

    abstract:BACKGROUND:Bell's palsy is the most frequent cause of unilateral facial paralysis. Inflammation is thought to play an important role in the pathogenesis of Bell's palsy. AIMS:Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are simple and inexpensive tests which are indicative of inflammatio...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15456

    authors: Atan D,İkincioğulları A,Köseoğlu S,Özcan KM,Çetin MA,Ensari S,Dere H

    更新日期:2015-04-01 00:00:00

  • Contralateral Suppression of Transient Evoked Otoacoustic Emissions in Children with Phonological Disorder.

    abstract:Background:Perception of acoustic details in the speech signal is important for speech sound development. The medial olivocochlear pathway, a part of the auditory efferent system, plays a role in stimulus-related control of the cochlea. One clinical tool to evaluate medial olivocohlear activity, which is thought to imp...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.galenos.2020.2020.4.168

    authors: Yılmaz Ş,Taş M,Bulut E

    更新日期:2020-12-07 00:00:00

  • Giant J (Osborn) Wave due to Bonsai Abuse: Comments on Clinical Practice.

    abstract:BACKGROUND:Osborn wave, typically associated with hypothermia, is currently referred to as one of the J wave syndromes due to its clinical potential to develop lethal cardiac arrhythmia; it may rarely be observed in a non-hypothermic setting such as cannabis abuse. CASE REPORT:In this paper, we presented two young cas...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2015.1233

    authors: Yalçın M,Aparcı M,Eroğlu M,Işılak Z,Özmen N

    更新日期:2017-01-01 00:00:00

  • Double primary tumors-renal cell carcinoma and duodenal mucinous adenocarcinoma.

    abstract::A 59-year old patient was admited to the Gastroenterology Clinic with the signs of gastrointestinal bleeding. Computerized tomography (CT) and a barium-meal radiography revealed a circumferential nodular wall narrowing and incomplete stricture at the D2 part of the duodenum. CT also showed a poorly demarcated mass in ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.076

    authors: Vuckovic N,Andrejic B,Djolai M,Zivojinov S,Sarcev K,Vuckovic D

    更新日期:2012-12-01 00:00:00

  • The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning.

    abstract:BACKGROUND:Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenos...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15932

    authors: Büyükdeligöz M,Hocaoğlu N,Oransay K,Tunçok Y,Kalkan Ş

    更新日期:2015-07-01 00:00:00

  • Sacral region massage as an alternative to the urinary catheter used to prevent urinary retention after cesarean delivery.

    abstract:OBJECTIVE:The aim of the study was to determine the effect of massage to the sacral region after cesarean delivery instead of employing a urinary catheter for the prevention of urinary retention. STUDY DESIGN:Cross sectional study. MATERIAL AND METHODS:This interventional study population consisted of 60 women who we...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.083

    authors: Dal U,Korucu AE,Eroğlu K,Karataş B,Yalçın A

    更新日期:2013-03-01 00:00:00

  • Short-Term Outcomes and Mortality of Late Preterm Infants.

    abstract:BACKGROUND:Late preterm infants have increased rates of morbidity and mortality compared to term infants. Determining the risk factors in these infants leads to more comprehensive preventive and treatment strategies. AIMS:Our aim was to analyse the morbidity rates such as respiratory system diseases, infections, conge...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.16721

    authors: Bulut C,Gürsoy T,Ovalı F

    更新日期:2016-03-01 00:00:00

  • Acute Haemodialysis-induced Changes in Tissue Doppler Echocardiography Parameters.

    abstract:BACKGROUND:Tissue Doppler imaging (TDI) is a method that determines the tissue motion and velocity within the myocardium. AIMS:To characterize acute haemodialysis (HD)-induced changes in TDI-derived indices for patients that have end-stage renal disease (ESRD). STUDY DESIGN:Cross sectional study. METHODS:Conventiona...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.13170

    authors: Sağ S,Yeşilbursa D,Yıldız A,Dilek K,Sentürk T,Serdar OA,Aydınlar A

    更新日期:2014-09-01 00:00:00

  • Polymorphisms of cytochrome p450 genes in three ethnic groups from Russia.

    abstract:OBJECTIVE:To determine the prevalence of the most common allelic variants of CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, CYP2F1, CYP2J2 and CYP2S1 in a representative sample of the three ethnic groups (Russians, Tatars and Bashkirs) from Republic of Bashkortostan (Russia), and compare the results with existing data publish...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.039

    authors: Korytina G,Kochetova O,Akhmadishina L,Viktorova E,Victorova T

    更新日期:2012-09-01 00:00:00

  • High-risk Factors of Respiratory Distress Syndrome in Term Neonates: A Retrospective Case-control Study.

    abstract:BACKGROUND:Respiratory distress syndrome (RDS) is a common critical disease in term neonates, but reasons for the occurrence of RDS remains unclear. AIMS:This study aimed to investigate the cause of RDS in full-term neonates by a retrospective case-control study. STUDY DESIGN:Case-control study. METHODS:Among the pa...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.8733

    authors: Liu J,Yang N,Liu Y

    更新日期:2014-03-01 00:00:00