Abstract:
BACKGROUND:Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS:To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. STUDY DESIGN:Descriptive study. METHODS:The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic. RESULTS:A total of 72 febrile neutropenia attacks were evaluated in 53 patients. In 46 febrile neutropenia attacks, microbiologic cultures revealed positive results. In culture-positive febrile neutropenia episodes a single bacterium was isolated in 32 cases and multiple strains were isolated in 14. In 15 patients, empirical antibiotic therapy was discontinued after 72 hours. These patients were clinically stable, without evident focus of infection and had negative culture results. Only 4 recurrent episodes were observed (27%) after cessation of antibiotherapy. No patient died as a result of recurrent infection. The 30-day and 100-day post-transplantation mortality rates of patients with febrile neutropenia episodes were 11.3% (6/53) and 3.8% (2/53), respectively. Infection-related 30-day and 100-day mortality rates were 7.5% (4/53) and 0% (0/53), respectively. CONCLUSION:The main message of our study is that early cessation of empirical antibiotherapy seems to be feasible in eligible patients without increasing febrile neutropenia mortality rates.
journal_name
Balkan Med Jjournal_title
Balkan medical journalauthors
Kaya AH,Tekgündüz E,Duygu F,Koca D,Bekdemir F,Batgi H,Ulu Uncu B,Yiğenoğlu TN,Dal MS,Çakar Kızıl M,Altuntaş Fdoi
10.4274/balkanmedj.2016.0012subject
Has Abstractpub_date
2017-04-05 00:00:00pages
132-139issue
2eissn
2146-3123issn
2146-3131journal_volume
34pub_type
杂志文章abstract:Background:Perception of acoustic details in the speech signal is important for speech sound development. The medial olivocochlear pathway, a part of the auditory efferent system, plays a role in stimulus-related control of the cochlea. One clinical tool to evaluate medial olivocohlear activity, which is thought to imp...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2020.4.168
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Gap junctions (GJ) are important in pain signalling at the spinal cord level. AIMS:The aim of this investigation was to study the effects of GJ on nociception and the analgesic/hyperalgesic effects of morphine following administration of carbenoxolone as a GJ blocker. Male Wistar rats (200-250 g) were divid...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.13099
更新日期:2014-06-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.13307
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS:To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and A...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2015.0865
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the ex-utero intrapartum therapy (EXIT) applied to 3 of the 7 cases with oropharyngeal or neck masses and review the indicators of the need for an EXIT procedure. CASE REPORT:Prenatal presentation, size and localization of the masses, existence of fetal hydrops and associ...
journal_title:Balkan medical journal
pub_type: 杂志文章
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journal_title:Balkan medical journal
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更新日期:2017-08-04 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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abstract:OBJECTIVE:To investigate possible mitochondrial DNA (mtDNA) mutations in patients with Leber's hereditary optic neuropathy (LHON) in order to provide a precise diagnosis and genetic counseling. MATERIAL AND METHODS:Between 1982 and 2007, ten patients were clinically diagnosed with LHON and six of these patients agreed...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.015
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. AIMS:We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic venous thromboembolism (VTE) in a Romanian po...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.7159
更新日期:2013-06-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Using innovative and scientific methods increases the rate of quitting in smokers. Short message service (SMS) is a communication tool widely used and well integrated in many people's daily lives. To increase adherence to appointments in smoking cessation clinics (SCC), it is thought that increased complianc...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.151610
更新日期:2016-09-01 00:00:00
abstract::Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells. There is no gross bony abnormality and, therefore, in these cases high-resolution compute...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2017.0367
更新日期:2017-09-29 00:00:00
abstract:Background:Regardless of the notable reduction in infant deaths worldwide over the last 30 years, the proportion of neonatal mortality in total child mortality is increasing. Aims:To perform a trend analysis of neonatal mortality in Serbia. Study Design:Descriptive observational study. Methods:Joinpoint regression w...
journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2020-04-10 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2017-09-29 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.15514
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective, randomized, double-blind study was to investigate the postoperative analgesic effects of levobupivacaine or tramadol infiltration administered prior to surgery in septorhinoplasty (SRP) or endoscopic sinus surgery (ESS). MATERIAL AND METHODS:Sixty ASA class I-III adult patients e...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.027
更新日期:2012-12-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract::In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination (i....
journal_title:Balkan medical journal
pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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journal_title:Balkan medical journal
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更新日期:2018-01-20 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Balkan medical journal
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更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. AIMS:To investigate whether indwelling time of double-J stent can predict which treatment modality is required for removal of the stent from the body. STUDY DESIGN:A multicentre, retrospective obser...
journal_title:Balkan medical journal
pub_type: 杂志文章,多中心研究
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更新日期:2017-08-04 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:The choroid plexuses, which could secrete a number of neurotrophins, have recently been used in transplantation in central nervous system diseases. AIMS:To study the mechanism of nerve regeneration in the central nervous system by grafting choroid plexus tissues. STUDY DESIGN:Animal experimentation. METHO...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.8259
更新日期:2013-12-01 00:00:00
abstract:Background:There is only limited information about the cost-effectiveness of drug-eluting stents compared with bare-metal stents in Turkey. Aims:To evaluate bare-metal and drug-eluting stents used in the treatment of coronary artery disease from the perspective of the reimbursement institution with cost-effectiveness ...
journal_title:Balkan medical journal
pub_type: 杂志文章
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更新日期:2019-08-22 00:00:00