Cortisol and Hippocampal Volume as Predictors of Active Suicidal Behavior in Major Depressive Disorder: Case Report.

Abstract:

BACKGROUND:Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the interrelation between cortisol as a marker of neuroendocrine theory as a response to stress, and hippocampal volume subfields in depression as a marker of neurogenesis and neuroplasticity theory. CASE REPORT:Here we present the case of a 52-year-old male patient with known history of MDD, who died as a result of completed suicide by hanging. The patient had been recently discharged from a psychiatric clinic, after being hospitalized for a major depressive episode (MDE). The result of the autopsy, medical records, laboratory analysis and a magnetic resonance image (MRI) of the patient were analyzed. Both the right and left volumes of the hippocampus were found to be smaller when compared to normal values reported in the literature. The morning level of cortisol was higher than the normal value. CONCLUSION:In a depressed patient with an acute stressful event, high levels of cortisol associated with decreased volume of the hippocampus could represent predictors for an increased risk of suicide.

journal_name

Balkan Med J

journal_title

Balkan medical journal

authors

Moica T,Grecu IG,Moica S,Grecu MG,Buicu GE

doi

10.5152/balkanmedj.2016.150842

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

706-708

issue

6

eissn

2146-3123

issn

2146-3131

pii

bmj-33-6-706

journal_volume

33

pub_type

杂志文章
  • Trends and Causes of Neonatal Mortality in Serbia, 1997-2016

    abstract:Background:Regardless of the notable reduction in infant deaths worldwide over the last 30 years, the proportion of neonatal mortality in total child mortality is increasing. Aims:To perform a trend analysis of neonatal mortality in Serbia. Study Design:Descriptive observational study. Methods:Joinpoint regression w...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.galenos.2020.2019.5.145

    authors: Lazarević K,Bogdanović D,Stošić L

    更新日期:2020-04-10 00:00:00

  • Management of Forgotten Ureteral Stents: Relationship Between Indwelling Time and Required Treatment Approaches.

    abstract:BACKGROUND:Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. AIMS:To investigate whether indwelling time of double-J stent can predict which treatment modality is required for removal of the stent from the body. STUDY DESIGN:A multicentre, retrospective obser...

    journal_title:Balkan medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.4274/balkanmedj.2015.1562

    authors: Polat H,Yücel MÖ,Utangaç MM,Benlioğlu C,Gök A,Çift A,Kalyenci B,Lök U,Gülaçtı U

    更新日期:2017-08-04 00:00:00

  • Comparison of Single and Prolonged Fluoroquinolone Prophylaxis and Risk Factors for Infectious Complications After Transrectal Prostate Biopsy

    abstract:Background:The ideal prophylaxis duration for transrectal ultrasonography-guided prostate biopsy is incompletely defined. Aims:To compare the infectious complications of transrectal ultrasonography-guided prostate biopsy with and without extended antibiotic prophylaxis. The secondary aim was to evaluate the risk facto...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2018.0477

    authors: Kalkanlı A,Gezmiş CT,Özkan A,Çilesiz NC,Yanaral F,Aydın M,Tandoğdu Z

    更新日期:2018-09-21 00:00:00

  • Classification and Current Management of Inner Ear Malformations.

    abstract::Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells. There is no gross bony abnormality and, therefore, in these cases high-resolution compute...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.0367

    authors: Sennaroğlu L,Bajin MD

    更新日期:2017-09-29 00:00:00

  • New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio.

    abstract:BACKGROUND:Bell's palsy is the most frequent cause of unilateral facial paralysis. Inflammation is thought to play an important role in the pathogenesis of Bell's palsy. AIMS:Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are simple and inexpensive tests which are indicative of inflammatio...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15456

    authors: Atan D,İkincioğulları A,Köseoğlu S,Özcan KM,Çetin MA,Ensari S,Dere H

    更新日期:2015-04-01 00:00:00

  • Amyopathic Dermatomyositis Associated with Histopathological Findings of Organizing Pneumonia and Pulmonary Vasculitis.

    abstract:BACKGROUND:Clinically, amyopathic dermatomyositis is a clinically distinct subgroup of dermatomyositis characterised by unique dermatological manifestations without muscle involvement. Clinically, amyopathic dermatomyositis is frequently associated with interstitial lung disease, which usually has a rapidly progressive...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.1061

    authors: Lim JU,Kang HS,Kim YH,Kim TJ

    更新日期:2017-08-04 00:00:00

  • Retroauricular Approach for Targeted Cochlear Therapy Experiments in Wistar Albino Rats.

    abstract:BACKGROUND:As the idea of stem cell technology in the treatment of sensorial hearing loss has emerged over the past decades, the need for in vivo models for related experiments has become explicit. One of the most common experimental models for inner ear stem cell delivery experiments is the Wistar albino rat. AIMS:To...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.0226

    authors: Mülazımoğlu S,Ocak E,Kaygusuz G,Gökcan MK

    更新日期:2017-05-05 00:00:00

  • eNOS Glu298Asp Polymorphism and Endothelial Dysfunction in Patients with and without End-stage Renal Disease.

    abstract:BACKGROUND:Chronic kidney diseases are known to influence nitric oxide metabolites (NOx) and asymmetric dimethylarginine (ADMA), though the exact mechanism is still poorly understood. AIMS:The purpose of the present study was to examine eNOS Glu298Asp gene polymorphism, plasma NOx and ADMA concentration in subjects wi...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.16566

    authors: İlhan N,Ateş K,İlhan N,Kaman D,Çeliker H

    更新日期:2016-03-01 00:00:00

  • Acute Haemodialysis-induced Changes in Tissue Doppler Echocardiography Parameters.

    abstract:BACKGROUND:Tissue Doppler imaging (TDI) is a method that determines the tissue motion and velocity within the myocardium. AIMS:To characterize acute haemodialysis (HD)-induced changes in TDI-derived indices for patients that have end-stage renal disease (ESRD). STUDY DESIGN:Cross sectional study. METHODS:Conventiona...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.13170

    authors: Sağ S,Yeşilbursa D,Yıldız A,Dilek K,Sentürk T,Serdar OA,Aydınlar A

    更新日期:2014-09-01 00:00:00

  • Azygos vein aneurysm mimicking paratracheal mass: dynamic magnetic resonance imaging findings.

    abstract::Aneurysms of the azygos vein are rare and can sometimes mimic a paratracheal or posterior mediastinal mass. It is important to confirm the diagnosis with radiologic tools before performing invasive procedures, which carry the risk of hemorrhage. Here, we present a case in a 79-year-old asymptomatic patient of an incre...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.095

    authors: Choo JY,Lee KY,Oh SJ,Je BK,Lee SH,Kim BH

    更新日期:2013-03-01 00:00:00

  • High-risk Factors of Respiratory Distress Syndrome in Term Neonates: A Retrospective Case-control Study.

    abstract:BACKGROUND:Respiratory distress syndrome (RDS) is a common critical disease in term neonates, but reasons for the occurrence of RDS remains unclear. AIMS:This study aimed to investigate the cause of RDS in full-term neonates by a retrospective case-control study. STUDY DESIGN:Case-control study. METHODS:Among the pa...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.8733

    authors: Liu J,Yang N,Liu Y

    更新日期:2014-03-01 00:00:00

  • The effects of tramadol and levobupivacaine infiltration on postoperative analgesia in functional endoscopic sinus surgery and septorhinoplasty.

    abstract:OBJECTIVE:The aim of this prospective, randomized, double-blind study was to investigate the postoperative analgesic effects of levobupivacaine or tramadol infiltration administered prior to surgery in septorhinoplasty (SRP) or endoscopic sinus surgery (ESS). MATERIAL AND METHODS:Sixty ASA class I-III adult patients e...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.027

    authors: Koputan MH,Apan A,Oz G,Köse EA

    更新日期:2012-12-01 00:00:00

  • Neuromuscular Dysfunction in Experimental Sepsis and Glutamine.

    abstract:BACKGROUND:Electrophysiological studies show that critical illness polyneuromyopathy appears in the early stage of sepsis before the manifestation of clinical findings. The metabolic response observed during sepsis causes glutamine to become a relative essential amino acid. AIMS:We aimed to assess the changes in neuro...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2016.140483

    authors: Çankayalı İ,Boyacılar Ö,Demirağ K,Uyar M,Moral AR

    更新日期:2016-05-01 00:00:00

  • Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism.

    abstract:BACKGROUND:Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS:To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and A...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2015.0865

    authors: Makay Ö,Özçınar B,Şimşek T,Arıcı C,Güngör B,Özbaş S,Akça T,Emre AU,Karadeniz Çakmak G,Akçay M,Ünal B,Girgin M,Girgin S,Görgülü S,Sezer A,Karataş A,Özemir İA,Aksakal N,Erel S,Uğurlu MÜ,Filiz Aİ,Atalay C,Uzunköy

    更新日期:2017-01-01 00:00:00

  • Auditory Hallucinations as Translational Psychiatry: Evidence from Magnetic Resonance Imaging.

    abstract::In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination (i....

    journal_title:Balkan medical journal

    pub_type: 杂志文章,评审

    doi:10.4274/balkanmedj.2017.1226

    authors: Hugdahl K

    更新日期:2017-12-01 00:00:00

  • Pericardial Effusion in Obstructive Sleep Apnea without Pulmonary Arterial Hypertension and Daily Hypoxemia - is it Unusual?

    abstract:Background:Pericardial effusion in chronic hypoxemic lung diseases, such as Obstructive Sleep Apnea syndrome, usually occurs after the development of severe pulmonary arterial hypertension. However, data about the frequency of pericardial effusions in Obstructive Sleep Apnea syndrome without pulmonary arterial hyperten...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.0580

    authors: Manov EI,Pencheva VP,Runev NM,Naydenov SN,Petrova DS,Georgiev OB

    更新日期:2018-05-29 00:00:00

  • Human Parasitic Diseases in Bulgaria in Between 2013-2014.

    abstract:BACKGROUND:In Bulgaria, more than 20 autochthonous human parasitic infections have been described and some of them are widespread. Over 50 imported protozoan and helminthic infections represent diagnostic and therapeutic challenges and pose epidemiological risks due to the possibility of local transmission. AIMS:To es...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.0167

    authors: Rainova I,Harizanov R,Kaftandjiev I,Tsvetkova N,Mikov O,Kaneva E

    更新日期:2018-01-20 00:00:00

  • Double primary tumors-renal cell carcinoma and duodenal mucinous adenocarcinoma.

    abstract::A 59-year old patient was admited to the Gastroenterology Clinic with the signs of gastrointestinal bleeding. Computerized tomography (CT) and a barium-meal radiography revealed a circumferential nodular wall narrowing and incomplete stricture at the D2 part of the duodenum. CT also showed a poorly demarcated mass in ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.076

    authors: Vuckovic N,Andrejic B,Djolai M,Zivojinov S,Sarcev K,Vuckovic D

    更新日期:2012-12-01 00:00:00

  • Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.

    abstract:BACKGROUND:Apigenin is a plant-derived compound belonging to the flavone class, which possess antioxidant, free-radical-scavenging and anti-inflammatory properties. AIMS:To address the effects of apigenin on serum anti-mullerian hormone levels, tissue oxidative stress parameters and histopathological changes in ovaria...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.1386

    authors: Soyman Z,Kelekçi S,Sal V,Şevket O,Bayındır N,Uzun H

    更新日期:2017-09-29 00:00:00

  • Chronic urinary retention after surgery for a rare case of adult presacral teratoma.

    abstract:BACKGROUND:Presacral teratomas are usually observed in the first two decades of life and have a 50-67% incidence of malignant transformation. Surgery is the treatment of choice. CASE REPORT:Here, we report the case of 24-year-old female with chronic urinary retention after surgery for a presacral teratoma. CONCLUSION...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2014.9449

    authors: Uğurlucan FG,Iyibozkurt AC,Karamustafaoğlu B,Keyif B,Eken MK,Yalçın O

    更新日期:2014-03-01 00:00:00

  • Primary Langerhans Cell Histiocytosis of the Extrahepatic Bile Duct Occurring in an Adult Patient

    abstract:Background:Langerhans cell histiocytosis is characterized by an abnormal proliferation of neoplastic Langerhans cells. Langerhans cell histiocytosis commonly affects the pediatric population, whereas presentation in adults remains a rare event. The presentation of Langerhans cell histiocytosis is highly variable, but t...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2017.1730

    authors: Obiorah IE,Velasquez AH,Kallakury B,Özdemirli M

    更新日期:2018-11-15 00:00:00

  • Fetal Oropharyngeal and Neck Tumors: Determination of the Need for Ex-Utero Intrapartum Treatment Procedure.

    abstract:BACKGROUND:The aim of this study was to assess the ex-utero intrapartum therapy (EXIT) applied to 3 of the 7 cases with oropharyngeal or neck masses and review the indicators of the need for an EXIT procedure. CASE REPORT:Prenatal presentation, size and localization of the masses, existence of fetal hydrops and associ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.150096

    authors: Özgünen FT,Güleç ÜK,Evrüke İC,Demir SC,Büyükkurt S,Yapıcıoğlu H,İskit S

    更新日期:2015-04-01 00:00:00

  • Comparison of sirolimus and colchicine treatment on the development of peritoneal fibrozis in rats having peritoneal dialysis.

    abstract:BACKGROUND:Continuous ambulatory peritoneal dialysis is a successful treatment modality for patients with end-stage renal disease. Peritoneal fibrosis (PF) is the most critical complication of long-term peritoneal dialysis (PD). AIMS:In our study, we aimed to compare the effects of colchicine and sirolimus on PF induc...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15183

    authors: Sağıroğlu T,Sayhan MB,Yağcı MA,Yalta T,Sağıroğlu G,Çopuroğlu E,Oğuz S

    更新日期:2015-01-01 00:00:00

  • Negative pressure wound therapy and skin graft in madura foot treatment.

    abstract::Madura foot is a rare, loca, chronic granulomatous skin infection which commonly affects the adult male foot. Medical treatment reduces the size of the lesion but surgical excision is necessary for radical treatment. We present a case of a 59 year old male farmer diagnosed as actinomadura of the right foot treated wit...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.014

    authors: Kalender AM,Baykan H,Ozkan F,Cıralık H,Oztürk P,Gül M,Uçmak H

    更新日期:2012-06-01 00:00:00

  • Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting.

    abstract:BACKGROUND:Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS:To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol ...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.2016.0012

    authors: Kaya AH,Tekgündüz E,Duygu F,Koca D,Bekdemir F,Batgi H,Ulu Uncu B,Yiğenoğlu TN,Dal MS,Çakar Kızıl M,Altuntaş F

    更新日期:2017-04-05 00:00:00

  • The importance of homozygous polymorphisms of methylenetetrahydrofolate reductase gene in romanian patients with idiopathic venous thromboembolism.

    abstract:BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. AIMS:We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic venous thromboembolism (VTE) in a Romanian po...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2013.7159

    authors: Hotoleanu C,Trifa A,Popp R,Fodor D

    更新日期:2013-06-01 00:00:00

  • Contralateral Suppression of Transient Evoked Otoacoustic Emissions in Children with Phonological Disorder.

    abstract:Background:Perception of acoustic details in the speech signal is important for speech sound development. The medial olivocochlear pathway, a part of the auditory efferent system, plays a role in stimulus-related control of the cochlea. One clinical tool to evaluate medial olivocohlear activity, which is thought to imp...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.4274/balkanmedj.galenos.2020.2020.4.168

    authors: Yılmaz Ş,Taş M,Bulut E

    更新日期:2020-12-07 00:00:00

  • Primary culture of choroid plexuses from neonate rats containing progenitor cells capable of differentiation.

    abstract:BACKGROUND:The choroid plexuses, which could secrete a number of neurotrophins, have recently been used in transplantation in central nervous system diseases. AIMS:To study the mechanism of nerve regeneration in the central nervous system by grafting choroid plexus tissues. STUDY DESIGN:Animal experimentation. METHO...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2013.8259

    authors: Huang SL,He XJ,Li ZF,Yao L,Yuan GL,Shi W

    更新日期:2013-12-01 00:00:00

  • The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning.

    abstract:BACKGROUND:Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenos...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2015.15932

    authors: Büyükdeligöz M,Hocaoğlu N,Oransay K,Tunçok Y,Kalkan Ş

    更新日期:2015-07-01 00:00:00

  • General or local anaesthesia in one-day thyroid surgery-does it matter?

    abstract:OBJECTIVE:We aimed to determine the safety and feasibility of general anaesthesia (GA) compared with local anaesthesia + Monitored Anaesthesia Care (LA+MAC) for One-Day Thyroid Surgery (ODTS); to assess patient and operator satisfaction with either of the anesthetic approaches. MATERIAL AND METHODS:We reviewed prospec...

    journal_title:Balkan medical journal

    pub_type: 杂志文章

    doi:10.5152/balkanmedj.2012.006

    authors: Belitova M,Pandev R,Karadimov D

    更新日期:2012-06-01 00:00:00