Abstract:
BACKGROUND:Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the interrelation between cortisol as a marker of neuroendocrine theory as a response to stress, and hippocampal volume subfields in depression as a marker of neurogenesis and neuroplasticity theory. CASE REPORT:Here we present the case of a 52-year-old male patient with known history of MDD, who died as a result of completed suicide by hanging. The patient had been recently discharged from a psychiatric clinic, after being hospitalized for a major depressive episode (MDE). The result of the autopsy, medical records, laboratory analysis and a magnetic resonance image (MRI) of the patient were analyzed. Both the right and left volumes of the hippocampus were found to be smaller when compared to normal values reported in the literature. The morning level of cortisol was higher than the normal value. CONCLUSION:In a depressed patient with an acute stressful event, high levels of cortisol associated with decreased volume of the hippocampus could represent predictors for an increased risk of suicide.
journal_name
Balkan Med Jjournal_title
Balkan medical journalauthors
Moica T,Grecu IG,Moica S,Grecu MG,Buicu GEdoi
10.5152/balkanmedj.2016.150842subject
Has Abstractpub_date
2016-11-01 00:00:00pages
706-708issue
6eissn
2146-3123issn
2146-3131pii
bmj-33-6-706journal_volume
33pub_type
杂志文章abstract:Background:Regardless of the notable reduction in infant deaths worldwide over the last 30 years, the proportion of neonatal mortality in total child mortality is increasing. Aims:To perform a trend analysis of neonatal mortality in Serbia. Study Design:Descriptive observational study. Methods:Joinpoint regression w...
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abstract:BACKGROUND:Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. AIMS:To investigate whether indwelling time of double-J stent can predict which treatment modality is required for removal of the stent from the body. STUDY DESIGN:A multicentre, retrospective obser...
journal_title:Balkan medical journal
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journal_title:Balkan medical journal
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journal_title:Balkan medical journal
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journal_title:Balkan medical journal
pub_type: 杂志文章
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