Abstract:
:Systemic AL amyloidosis is a plasma cell dyscrasia with a characteristic clinical phenotype caused by multi-organ deposition of an amyloidogenic monoclonal protein. This condition poses a unique management challenge due to the complexity of the clinical presentation and the narrow therapeutic window of available therapies. Improved appreciation of the need for risk stratification, standardised use of sensitive laboratory testing for monitoring disease response, vigilant supportive care and the availability of newer agents with more favourable toxicity profiles have contributed to the improvement in treatment-related mortality and overall survival seen over the past decade. Nonetheless, with respect to the optimal management approach, there is a paucity of high-level clinical evidence due to the rarity of the disease, and enrollment in clinical trials is still the preferred approach where available. This review will summarise the Clinical Practice Guidelines on the Management of Systemic Light Chain (AL) Amyloidosis recently prepared by the Medical Scientific Advisory Group of the Myeloma Foundation of Australia. It is hoped that these guidelines will assist clinicians in better understanding and optimising the management of this difficult disease.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Weber N,Mollee P,Augustson B,Brown R,Catley L,Gibson J,Harrison S,Ho PJ,Horvath N,Jaksic W,Joshua D,Quach H,Roberts AW,Spencer A,Szer J,Talaulikar D,To B,Zannettino A,Prince HMdoi
10.1111/imj.12566subject
Has Abstractpub_date
2015-04-01 00:00:00pages
371-82issue
4eissn
1444-0903issn
1445-5994journal_volume
45pub_type
杂志文章,评审abstract::The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1046/j.1445-5994.2001.00068.x
更新日期:2001-08-01 00:00:00
abstract:AIMS:To survey the practice among gastroenterologists in Australia relating to screening for latent infections and vaccination of patients with inflammatory bowel disease prior to treatment with tumour necrosis factor alpha (TNF-α) inhibitors. METHODS:A structured 15 question electronic survey was advertised to gastro...
journal_title:Internal medicine journal
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doi:10.1111/j.1445-5994.2009.02114.x
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journal_title:Internal medicine journal
pub_type: 杂志文章
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journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00460.x
更新日期:2003-09-01 00:00:00
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journal_title:Internal medicine journal
pub_type: 杂志文章,评审
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journal_title:Internal medicine journal
pub_type: 杂志文章,评审
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journal_title:Internal medicine journal
pub_type: 杂志文章,评审
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journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
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journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析
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更新日期:2018-10-01 00:00:00
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journal_title:Internal medicine journal
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Internal medicine journal
pub_type: 杂志文章
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journal_title:Internal medicine journal
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
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更新日期:2014-09-01 00:00:00
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更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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更新日期:2018-05-01 00:00:00
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