Abstract:
:A yeast-mycelium (Y-M) transition of Candida albicans (3153A) was induced by 1.5 mM CaCl2.2H2O in defined liquid medium, pH 7, at 25 degrees C. Germ tube formation was detected after approximately 8 h and peaks of maximum germination occurred at approximately 20 h in all experimental treatments. Non-toxic concentrations of the calmodulin inhibitor R24571 almost completely suppressed germ tube formation whereas trifluoperazine (TFP) and the Ca2+ ionophore A23187 were only about half as effective. Further Ca2+ addition failed to reverse the inhibitory effect of R24571 and induced only about 10% of the cells inhibited by TFP or A23187 to germinate.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Sabie FT,Gadd GMdoi
10.1007/BF00436783subject
Has Abstractpub_date
1989-10-01 00:00:00pages
47-54issue
1eissn
0301-486Xissn
1573-0832journal_volume
108pub_type
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