Involvement of a Ca2+-calmodulin interaction in the yeast-mycelial (Y-M) transition of Candida albicans.

Abstract:

:A yeast-mycelium (Y-M) transition of Candida albicans (3153A) was induced by 1.5 mM CaCl2.2H2O in defined liquid medium, pH 7, at 25 degrees C. Germ tube formation was detected after approximately 8 h and peaks of maximum germination occurred at approximately 20 h in all experimental treatments. Non-toxic concentrations of the calmodulin inhibitor R24571 almost completely suppressed germ tube formation whereas trifluoperazine (TFP) and the Ca2+ ionophore A23187 were only about half as effective. Further Ca2+ addition failed to reverse the inhibitory effect of R24571 and induced only about 10% of the cells inhibited by TFP or A23187 to germinate.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Sabie FT,Gadd GM

doi

10.1007/BF00436783

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

47-54

issue

1

eissn

0301-486X

issn

1573-0832

journal_volume

108

pub_type

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