Purified moniliformin does not affect the force or rate of contraction of isolated guinea pig atria.

Abstract:

:Chronic exposure to moniliformin results in the development of myocardial hypertrophy and degeneration. The cause of this hypertrophy is unknown. However, moniliformin-induced hypoxia or altered function of cardiac pyruvate dehydrogenase, rather than direct cardiostimulation have been proposed as potential mechanisms. Isolated guinea pig atria were used in a cumulative concentration-response model to evaluate the direct effect of moniliformin on the rate and force of atrial contraction. Moniliformin did not affect the rate or force of atrial contraction. These results are consistent with the hypothesis that moniliformin does not have a cardiostimulatory effect. Therefore cardiac stimulation. e.g. stimulation of beta-adrenergic receptors, is unlikely to be the cause of the myocardial hypertrophy observed in poultry chronically intoxicated with moniliformin.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Reams RY,Thacker HL,Harrington DD,Novilla MN,Wilson B

doi

10.1007/BF00439122

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

115-8

issue

2

eissn

0301-486X

issn

1573-0832

journal_volume

133

pub_type

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