Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.

Abstract:

:Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Karunasena E,Larrañaga MD,Simoni JS,Douglas DR,Straus DC

doi

10.1007/s11046-010-9330-5

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

377-90

issue

6

eissn

0301-486X

issn

1573-0832

journal_volume

170

pub_type

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