Preparation of the Fusarium toxin, nivalenol, by oxidation of the putative biosynthetic precursor, 7-deoxynivalenol.

Abstract:

:Nivalenol is a toxic trichothecene metabolite which is produced by a number of different Fusarium species. However, the nature of its immediate biosynthetic precursor is not known. Oxidation of 7-deoxynivalenol(3 alpha,4 beta,15-trihydroxy-12,13- epoxytrichothec-9-ene-8-one) to nivalenol occurred with reagents known to react by a free radical pathway, such as hydrogen peroxide-ferrous ion-ascorbic acid or lead tetracetate, but not with electrophilic reagents requiring prior formation of the enol. These results suggest that 7-deoxynivalenol or an acetylated derivative could be the biosynthetic precursor of nivalenol.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Ehrlich KC

doi

10.1007/BF00707546

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

111-4

issue

2-3

eissn

0301-486X

issn

1573-0832

journal_volume

107

pub_type

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