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A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.

Abstract：

:Recently, a cDNA from the hepatitis C virus (HCV) RNA genome has been isolated in the USA from a chronically infected chimpanzee. In order to isolate HCV cDNA derived from human material, RNA was extracted from plasma of a Japanese blood donor implicated in post-transfusion non-A, non-B hepatitis and HCV cDNA was synthesized and amplified by the PCR method using HCV-specific oligonucleotide primers. The cDNA fragment, 583 nucleotides long, showed 79.8% homology at the nucleotide level and 92.2% homology at the amino acid level compared with the prototype HCV cDNA. These results provides further evidence to show that HCV is closely associated with the development of post transfusion non-A, non-B hepatitis.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Kubo Y,Takeuchi K,Boonmar S,Katayama T,Choo QL,Kuo G,Weiner AJ,Bradley DW,Houghton M,Saito I

doi

10.1093/nar/17.24.10367

subject

Has Abstract,Author List Incomplete

pub_date

1989-12-25 00:00:00

pages

10367-72

issue

24

eissn

0305-1048

issn

1362-4962

journal_volume

17

pub_type

杂志文章

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