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Comparison of ocular response analyzer parameters in primary open angle glaucoma and exfoliative glaucoma patients.

Abstract：

AIM:We sought to identify differences in the following measures of the ocular response analyser (ORA) between primary open angle glaucoma (POAG) and exfoliative glaucoma (EXG) patients: Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg). We also sought to relate these ORA measures with central corneal thickness (CCT). MATERIALS AND METHODS:This cross-sectional study was conducted on a total of 162 individuals (46 EXG patients, 66 POAG patients and 50 healthy subjects without any ocular and systemic disease). ORA measurements were performed, and a minimum of three readings were obtained from each test subject. Groups were compared according to their ORA parameters. RESULTS:The mean CH levels of the EXG, POAG and healthy subjects were 7.6 ± 2.1, 9.1 ± 1.9 and 9.6 ± 1.7 mmHg, respectively. CH was significantly lower in the EXG patients compared to the other groups (P < 0.001).The mean CRF levels of the EXG, POAG and healthy subjects were 9.0 ± 2.0, 10.1 ± 1.7 and 9.8 ± 1.8mmHg, respectively. CRF levels in the eyes of the EXG patients were significantly lower compared to those of either the POAG patients (P = 0.005) or the healthy subjects (P = 0.03), but there was no significant difference in CRF levels between the POAG patients and the healthy subjects (P = 0.59). There was a significant positive correlation between CH and CCT in the EXG patients and healthy subjects (P < 0.001), but this correlation was not present in the POAG patients (P = 0.70). CONCLUSIONS:In this study, CH and CRF were found to be significantly reduced in the eyes of EXG patients compared to both the POAG patients and healthy subjects. Reduced CH in EXG patients might result in decreased support of peripapillary scleral structure and increased damage to the optic nerve during IOP increase.

journal_name

Indian J Ophthalmol

journal_title

Indian journal of ophthalmology

authors

Beyazyıldız E,Beyazyıldız O,Arifoğlu HB,Altıntaş AK,Köklü SG

doi

10.4103/0301-4738.138180

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

782-7

issue

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2014_62_7_782_138180

journal_volume

pub_type

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Comparison of ocular response analyzer parameters in primary open angle glaucoma and exfoliative glaucoma patients.