Abstract:
BACKGROUND AND PURPOSE:Current techniques for epiphysiodesis involve opening of cortical windows; use of staples, screws, and tension devices; and fusion with curettes or drills. Complications may have serious consequences. There is a need for a more reliable, precise, and less traumatic procedure that overcomes the known complications from existing techniques. We analyzed a new epiphysiodesis technique using radio-frequency ablation (RFA) in a porcine model. METHODS:Six 35-kg and two 25-kg immature pigs were used. 1 hind leg of each animal was randomly selected and the proximal tibia growth plate was ablated laterally and medially. The contralateral leg was used as a control. MR images were obtained immediately after the ablation and 12 weeks later for 6 animals, and 24 weeks later for the other 2 animals. CT was done for the 2 animals that were followed for 24 weeks for proof of bone bridges. RESULTS:Both tibias were equal in length initially. At the 12-week follow-up, there was an average leg length discrepancy of 3.9 mm (95% CI: 3.0-4.8), and at 24 weeks the difference was 8.4 mm and 7.5 mm. No damage to the adjacent tissue was found. Bone bridges and physeal closure were found after 24 weeks. The pigs showed no discomfort after the intervention. INTERPRETATION:We found RFA to be feasible for epiphysiodesis in a pig model. The method is minimally invasive and recovery may be quick compared to conventional methods. We recommend that the method should be tested in larger-scale safety studies before clinical application.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Shiguetomi-Medina JM,Rahbek O,Abood AA,Stødkilde-Jørgensen H,Møller-Madsen Bdoi
10.3109/17453674.2014.939014subject
Has Abstractpub_date
2014-09-01 00:00:00pages
538-42issue
5eissn
1745-3674issn
1745-3682journal_volume
85pub_type
杂志文章abstract:BACKGROUND:Bone-saving hip arthroplasty techniques, which facilitate revision, are gaining importance as the number of hip replacements in younger patients increases. PATIENTS AND METHODS:123 CUT femoral neck prostheses (ESKA Implants, Lübeck, Germany) were implanted in 113 patients (average age 53 years) between 1999...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014301
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Bones used in mechanical studies are frequently harvested from human cadavers that have been embalmed in a buffered formaldehyde solution. It has been reported that formaldehyde fixation or freezing hardly affects the mechanical properties of bone after a storage period of several weeks. However,...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016759
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hip resurfacing arthroplasty is being used more and more frequently. The small ratio in size between the resurfaced femoral head and the relatively thick femoral neck raises the question of whether the range of motion is sufficient, particularly with regard to the high mobility required by younge...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016803
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tourniquet-related nerve injuries remain a concern in orthopedic surgery. The cuff pressures used today are generally lower, and therefore a decreasing incidence of peripheral nerve injuries might also be expected. However, there have been few neurophysiological studies describing the outcome aft...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2013.782525
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Periacetabular osteotomy improves radiographic predictors of osteoarthrosis and diminishes pain and functional impairment. No changes in function quantified by gait analysis have yet been documented. We evaluated the functional outcome of periacetabular osteotomy in relation to gait. METHODS:The gait patter...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610045920
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:We have previously reported that 6 months of oral treatment with clodronate reduced the migration of the NexGen total knee prosthesis during the first postoperative year, as measured by radiostereometry (RSA). We now report the 4-year results. METHODS:This was a double-blind randomized study, using RSA with...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670610013213
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There are limited population-based data on utilization, outcomes, and trends in total knee arthroplasty (TKA). The purpose of this study was to examine TKA utilization and short-term outcomes in a pre-paid health maintenance organization (HMO), and to determine whether rates and revision burden c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016902
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The frontal pelvic plane has traditionally served as the reference plane for implantation of the acetabular cup during total hip arthroplasty, with referencing performed with the patient supine on the operating table. During daily activities in an upright position, the frontal pelvic plane changes from a hor...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510045471
更新日期:2005-12-01 00:00:00
abstract::Background and purpose - Several surgical approaches are used in primary total hip arthroplasty (THA). In this randomized controlled trial we compared gait, risk of fall, self-reported and clinical measurements between subjects after direct superior approach (DSA) versus posterolateral approach (PL) for THA. Patients ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1865633
更新日期:2021-01-07 00:00:00
abstract::Background and purpose - During revision hip arthroplasty the dual mobility cup (DMC) is widely used to prevent dislocation despite limited knowledge of implant longevity. We determined the 5-year cup re-revision rates of DMC compared with unipolar cups (UC) following cup revisions in the Netherlands. Patients and met...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1617560
更新日期:2019-08-01 00:00:00
abstract::Background and purpose - Radiostereometric analysis (RSA) is the gold standard to study micromotion of joint replacements. RSA requires the acquisition of additional radiographs increasing the radiation dose of patients included in RSA studies. It is important to keep this dose as low as possible. Effective radiation ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1767443
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Integration of repaired cartilage with surrounding native cartilage is a major challenge for successful tissue-engineering strategies of cartilage repair. We investigated whether incorporation of mesenchymal stem cells (MSCs) into the collagen scaffold improves integration and repair of cartilage...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.958807
更新日期:2015-02-01 00:00:00
abstract::Background and purpose - Osteoarthritis has become the most common indication for shoulder arthroplasty in Denmark, and the treatment strategies have changed towards the use of anatomical total shoulder arthroplasty and reverse shoulder arthroplasty. We investigated whether changes in the use of arthroplasty types hav...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2019.1633759
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Following transtibial amputation, a rigid dressing of plaster of Paris has been reported to have advantages over a soft dressing regarding wound healing and reduction of edema, but use of the former may be limited by difficulties in application and in gaining access to the wound. An easily applic...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670710015265
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:It is not known whether postoperative occupational therapy is of value for hip fracture patients. In this randomized trial we evaluated the effects of an individualized, postoperative, occupational training (OT) program on the patient's self-reported health-related quality of life (HRQL) and self-reported ab...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670610045786
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The osteogenic potency of erythropoietin (EPO) has been documented. However, its efficacy in a large-animal model has not yet been investigated; nor has a clinically safe dosage. The purpose of this study was to overcome such limitations of previous studies and thereby pave the way for possible c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.889981
更新日期:2014-04-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest th...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453670903448257
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hospital volume has been suggested to be one of the best indicators of adverse orthopedic events in patients undergoing THR surgery. We therefore evaluated the effect of hospital volume on the length of stay, re-admissions, and complications of THR at the population level in Finland. METHODS:30,...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.533930
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Operative findings during revision of metal-on-metal hip arthroplasty (MOMHA) vary widely and can involve massive soft tissue and bone disruption. As a result, planning of theater time and resources is difficult, surgery is challenging, and outcomes are often poor. We describe our experience with...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2013.797313
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Optical coherence tomography (OCT) is a light-based imaging technique suitable for depiction of thin tissue layers such as articular cartilage. Quantification of results and direct comparison with a reference standard is needed to confirm the role of OCT in cartilage evaluation. MATERIALS AND ME...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.979312
更新日期:2015-04-01 00:00:00
abstract::Background and purpose - Larger prospective studies investigating periacetabular osteotomy (PAO) with patient-reported outcome measures developed for young patients are lacking. We investigated changes in patient-reported outcome (PRO), changes in muscle-tendon pain, and any associations between them from before to 1 ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1555637
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Since the osteogenic potential of bone marrow derived mesenchymal stem cells (BMSCs) becomes reduced with passage, establishment of culture condition that permit the rapid expansion of BMSCs while retaining their potential for differentiation is needed for clinical application. Bone morphogenetic proteins st...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710013816
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Most lung cancer patients with skeletal metastases have a short survival and it is difficult to identify those patients who will benefit from palliative surgery. We report complication and survival rates in a consecutive series of lung cancer patients who were operated for symptomatic skeletal me...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.552779
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Most patients with femoroacetabular impingement (FAI) have a cam deformity, which may be quantified by measuring the alpha angle and anterior offset ratio (AOR). Knowledge of what constitutes a "normal" alpha angle and AOR is limited. We defined the reference intervals of these measurements from ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453671003619011
更新日期:2010-02-01 00:00:00
abstract:UNLABELLED:BACKGROUND AND PURPOSE Analgesics can have undesirable effects. We assessed whether a single preoperative dose of 120 mg etoricoxib reduces the need for additional opioids after therapeutic arthroscopic knee surgery. METHODS A double-blind, placebo-controlled study was performed at a single center. 66 patien...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2012.747053
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:External fixators allowing movement during fracture healing are commonly used for treatment of unstable distal radius fractures. The dynamic Dynawrist fixator with the distal pins in metacarpal bone may avoid fixation problems in comminuted fractures and may reduce the risk of nerve injury. We co...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670902807433
更新日期:2009-02-01 00:00:00
abstract::Background and purpose - The long-term effects of computer-assisted surgery in total knee replacement (CAS) compared to conventionally operated knee replacement (CON) are still not clear. We compared survivorship and relative risk of revision in CAS and CON based on data from the Norwegian Arthroplasty Register. Patie...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2016.1244884
更新日期:2016-12-01 00:00:00
abstract::Background and purpose - Alternative bearing surfaces such as ceramics and highly crosslinked polyethylene (HXLPE) were developed in order to further improve implant performance of total hip arthroplasties (THAs). Whether these alternative bearing surfaces result in increased longevity is subject to debate. Patients a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1405669
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Commercial gentamicin-loaded bone cement beads (Septopal) constitute an effective delivery system for local antibiotic therapy. These beads are not available in all parts of the world, and are too expensive for frequent use in others. Thus, orthopedic surgeons worldwide make antibiotic-loaded bea...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903389782
更新日期:2009-10-01 00:00:00
abstract::Background and purpose - Understanding the key drivers of hospital variation in postoperative infections after hip fracture surgery is important for directing quality improvements. Therefore, we investigated variation in the risk of any infection, and subgroups of infections including pneumonia and sepsis after hip fr...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1863688
更新日期:2020-12-18 00:00:00