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The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: a successful drug discovery tale.

Abstract：

:Modulation of sphingosine 1-phosphate (S1P) signaling represents a solid opportunity for multiple sclerosis (MS) treatment. In this issue, a team at Novartis reports on the identification of the first direct S1P lyase (S1PL) inhibitors as new MS agents. One of the most potent inhibitors reported in their work was demonstrated to be orally bioavailable and fully protective in a MS disease animal model. This work represents an outstanding example of a drug discovery campaign that started with the target identification and validation and culminated with the preclinical tests on animal disease models.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cosconati S,Novellino E

doi

10.1021/jm500845y

subject

Has Abstract

pub_date

2014-06-26 00:00:00

pages

5072-3

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

57

pub_type

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