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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

Abstract：

:Design of small-molecule inhibitors (MDM2 inhibitors) to block the MDM2-p53 protein-protein interaction has been pursued as a new cancer therapeutic strategy. In recent years, potent, selective, and efficacious MDM2 inhibitors have been successfully obtained and seven such compounds have been advanced into early phase clinical trials for the treatment of human cancers. Here, we review the design, synthesis, properties, preclinical, and clinical studies of these clinical-stage MDM2 inhibitors.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Zhao Y,Aguilar A,Bernard D,Wang S

doi

10.1021/jm501092z

subject

Has Abstract

pub_date

2015-02-12 00:00:00

pages

1038-52

issue

3

eissn

0022-2623

issn

1520-4804

journal_volume

58

pub_type

杂志文章,评审

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