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Synthesis and radioprotective activity of new cysteamine and cystamine derivatives.

Abstract：

:A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Oiry J,Pue JY,Imbach JL,Fatome M,Sentenac-Roumanou H,Lion C

doi

10.1021/jm00161a015

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

2217-25

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

29

pub_type

杂志文章

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