Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.

Abstract:

:We report a three-dimensional model of the alpha5beta1 integrin headgroup bound to the most potent and selective ligand (SJ749) known to date. The model was built using the comparative protein modeling method, and it is consistent with experimental data. From this study, we identified two potentially important regions in the alpha5beta1 receptor that are peculiar to this integrin and might be worth considering for drug targeting.

journal_name

J Med Chem

authors

Marinelli L,Meyer A,Heckmann D,Lavecchia A,Novellino E,Kessler H

doi

10.1021/jm040224i

keywords:

subject

Has Abstract

pub_date

2005-06-30 00:00:00

pages

4204-7

issue

13

eissn

0022-2623

issn

1520-4804

journal_volume

48

pub_type

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