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Synthesis of aziridinylallylaminophosphine oxides and sulfides as potential adjuvant cancer chemotherapeutic agents.

Abstract：

:Bis (1-aziridinyl)(hexahydro-1H-azepin-1-yl)phosphine sulfide, an active anticancer agent with low hematopoietic toxicity in animals and man, was recommended several years ago for breast cancer adjuvant chemotherapy as an alternate drug to thiotepa. This hope had led to the syntheses of aziridinylallylaminophosphine oxides or sulfides (compounds I-XVII) in our laboratories. The resurgent interest in this area of cancer chemotherapy encouraged us to report our synthetic work as well as their evaluation as both anticancer agents and insect chemosterilants. Based on observed antitumor activity in animals, low chemosterilant activity in female species (insects and rats), and histochemical observation of tissue toxicity in rat testes but not in ovaries, these new agents are of potential interest to the breast cancer adjuvant chemotherapy program.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Tsou KC,Bender D,Santora N,David L,Damle S

doi

10.1021/jm00228a014

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

806-10

issue

6

eissn

0022-2623

issn

1520-4804

journal_volume

19

pub_type

杂志文章

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