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Synthesis and central nervous system evaluation of some 5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones.

Abstract：

:A series of 1-R-5-alkoxy-3H-1,4-benzodiazepin-2(1H)-ones was prepared and evaluated for central nervous system depressant activity. Several of these compounds, in particular, 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2(1H)-one (2), gave a profile and activity level similar to diazepam when measured in mice.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Gogerty JH,Griot RG,Habeck D,Iorio LC,Houlihan WJ

doi

10.1021/jm00217a019

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

952-6

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

20

pub_type

杂志文章

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