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Piperazinylquinoxalines with central serotoninmimetic activity.

Abstract：

:Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Lumma WC Jr,Hartman RD,Saari WS,Engelhardt EL,Lotti VJ,Stone CA

doi

10.1021/jm00133a019

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

93-101

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

24

pub_type

杂志文章

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