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Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

Abstract：

:A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3. Modification based on the homology model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biology of GPR120 and for developing new candidate therapeutic agents.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Suzuki T,Igari S,Hirasawa A,Hata M,Ishiguro M,Fujieda H,Itoh Y,Hirano T,Nakagawa H,Ogura M,Makishima M,Tsujimoto G,Miyata N

doi

10.1021/jm800970b

subject

Has Abstract

pub_date

2008-12-11 00:00:00

pages

7640-4

issue

23

eissn

0022-2623

issn

1520-4804

journal_volume

51

pub_type

杂志文章

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