当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > 4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.

4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.

Abstract：

:The preparation and testing of the two racemic diastereoisomers and the four optically active enantiomers of the title compound in in vitro and in vivo models for determining potential antipsychotic activity are described. Both racemic diastereoisomers and two of the four chiral enantiomers are potent and long-acting neuroleptic compounds.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Welch WM,Ewing FE,Harbert CA,Weissman A,Koe BK

doi

10.1021/jm00182a025

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

949-52

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

23

pub_type

杂志文章

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