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QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.

Abstract：

:A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Macchiarulo A,De Luca L,Costantino G,Barreca ML,Gitto R,Pellicciari R,Chimirri A

doi

10.1021/jm0310838

keywords:

subject

Has Abstract

pub_date

2004-03-25 00:00:00

pages

1860-3

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

47

pub_type

杂志文章

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