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Antimalarial activity of yingzhaosu A analogues.

Abstract：

:Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kim HS,Begum K,Ogura N,Wataya Y,Tokuyasu T,Masuyama A,Nojima M,McCullough KJ

doi

10.1021/jm020208q

keywords:

subject

Has Abstract

pub_date

2002-10-10 00:00:00

pages

4732-6

issue

21

eissn

0022-2623

issn

1520-4804

pii

jm020208q

journal_volume

45

pub_type

杂志文章

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