Focus on the controversial activation of human iNKT cells by 4-deoxy analogue of KRN7000.

Abstract:

:4-Deoxy-alpha-GalCer analogues are considered weaker agonists than KRN7000 for the stimulation of human iNKT cells, but this remains strongly debated. In this work, we described a strategy toward 4-deoxy-alpha-GalCers with, as a key step, a metathesis reaction allowing sphingosine modifications from a single ethylenic alpha-galactoside precursor. The 4-deoxy-KRN7000 derivative 2, described here, induced potent cytokinic responses, comparable to those of KRN7000, both from human iNKT cells in vitro and from their murine counterpart in vivo.

journal_name

J Med Chem

authors

Lacône V,Hunault J,Pipelier M,Blot V,Lecourt T,Rocher J,Turcot-Dubois AL,Marionneau S,Douillard JY,Clément M,Le Pendu J,Bonneville M,Micouin L,Dubreuil D

doi

10.1021/jm900290r

subject

Has Abstract

pub_date

2009-08-13 00:00:00

pages

4960-3

issue

15

eissn

0022-2623

issn

1520-4804

journal_volume

52

pub_type

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