Abstract：
:The conversion of levamisole to aminorex in horses was first described in 2009 and, for the first time, confirmed in humans two years later by our laboratory. Aminorex and levamisole interfere with serotonin metabolism and both are proven cause of potentially fatal idiopathic pulmonary hypertension (IPH). Because most of the world's seizures of illicit cocaine is now contaminated with levamisole, this raises the possibility that users of levamisole adulterated cocaine users may be at risk for IPH. Here we describe the first case of IPH in a user of levamisole-contaminated cocaine. Levamisole and aminorex were both identified and quantified in hair and other biological specimens by means gas chromatography/mass spectrometry system (levamisole: urine, 75.05ng/mL; blood, 15.05ng/mL; brain, >0.15ng/g; liver, >0.15ng/g; hair, 12.15ngmg; aminorex: urine, 38.62ng/mL; blood, 8.92ng/mL, brain >0.15ng/g; liver, 0.15ng/g; hair 7.35ng/mg; cocaine, benzoylecgonine, morphine, 6-acetylmorphine, methadone, 2-ethylidine-1, 5-dimetil-3, 3 diphenylpyrrolidine were also detected). Moreover histological changes associated with IPH were observed in the lung. As IPH produces relatively non-specific symptoms in its early stages, this index case may serve as a harbinger of many more cases to come. It should also alert clinicians to the possibility that their patient may be suffering from this relatively rare disorder.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Karch SB,Defraia B,Messerini L,Mari F,Vaiano F,Bertol Edoi
10.1016/j.forsciint.2014.03.028subject
Has Abstractpub_date
2014-07-01 00:00:00pages
e7-10eissn
0379-0738issn
1872-6283pii
S0379-0738(14)00131-5journal_volume
240pub_type
杂志文章abstract：:In this study, the use of benchtop NMR spectroscopy in the analysis of solids and liquids used and/or produced during the HI reduction of pseudoephedrine was evaluated. The study focused on identifying organic precursors and phosphorus containing compounds used in and/or produced during the manufacturing process. Samp...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.06.026
更新日期：2017-09-01 00:00:00
abstract：:An accurate and precise estimate of stature can be very useful in the analysis of human remains in forensic cases. A problem with many stature estimation methods is that an unknown individual must first be assigned to a specific group before a method can be applied. Group membership has been defined by sex, age, year ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.12.011
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION:Age assessment based on dental development is often requested in order to assess whether an individual is older or younger than 18 years of age. There are several statistical approaches to estimate age based upon third molar development. The aim of this study was to apply the principles of transition analy...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110145
更新日期：2020-03-01 00:00:00
abstract：:By definition, sudden infant death syndrome (SIDS) requires diagnosis through exclusion by conducting an autopsy. To obtain a reliable diagnosis of this disease, an autopsy is essential. However, the frequency with which autopsies are conducted in Japan is not sufficient to meet the need associated with the diagnosis ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00148-2
更新日期：2002-09-14 00:00:00
abstract：:Molecular analyses in a post-mortem setting are becoming increasingly common, particularly in cases of sudden unexplained death, with the aim of identifying genetic mutations which may be responsible for causing death. In retrospective investigations, the access to suitable autopsy biological samples may be limited, a...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2017.09.020
更新日期：2017-11-01 00:00:00
abstract：:Body components of aviation accident fatalities are often scattered, disintegrated, commingled, contaminated, and/or putrefied at accident scenes. These situations may impose difficulties in victim identification/tissue matching. The prevalence of misidentification in relation to aviation accident forensic toxicology ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.06.024
更新日期：2011-03-20 00:00:00
abstract：:An accurate and rapid screening test for nine quaternary ammonium compounds (suxamethonium chloride, pancuronium bromide, ambenonium chloride, benzethonium chloride, distigmine bromide, methylbenactyzium bromide, neostigmine bromide, propantheline bromide and pyridostigmine bromide) by direct inlet electron impact ion...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(91)90213-3
更新日期：1991-10-01 00:00:00
abstract：:Protein-based medicines, or large molecule medicines, are innovative products used to treat various diseases like hepatitis or cancer. This new generation of molecules are usually expensive, and thus represents an attractive target for the counterfeiters. Due to the complexity of their chemical structure, their analys...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.07.012
更新日期：2017-09-01 00:00:00
abstract：:Allele- and genotype frequencies for the polymerase chain reaction-based DNA genetic marker HLA-DQA1 were determined previously in a Swiss sample population (n = 200). In this study we subtyped the allele 4 in the same Swiss Caucasian population sample (distinguishing the 4.1 allele from the 4.2 and 4.3 alleles) using...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(96)02008-7
更新日期：1996-11-11 00:00:00
abstract：:An ingestion of an unknown quantity of U 46 D-Fluid (500 g dichlorophenoxyacetic acid/l) in a suicide is described. Although 2,4-dichlorophenoxyacetic acid (2,4 D) is widely used as a herbicide, intoxications are relatively rare. Quantitation of 2,4-D was performed by diethyl ether extraction from acidified samples (v...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90295-x
更新日期：1994-03-01 00:00:00
abstract：:Highly efficient multifunctional agarose SERS test stripes has been fabricated by a convenient facile approach. SERS stripes were found to be highly sensitive, robust, and capable to alleviate the two major drawbacks of filter paper based SERS substrate i.e. the weak adhesion of plasmonic nanoparticles and the diffusi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.01.019
更新日期：2014-04-01 00:00:00
abstract：:As well as being the route for gaseous exchange, the nasal passages protect the lungs from debris and fine particulates inhaled during breathing. Foreign particles are trapped by mucus produced by membranes that line the upper respiratory tract. Even when a corpse has skeletonised, particles can be retrieved from the ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.11.019
更新日期：2006-11-22 00:00:00
abstract：:5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since 2016. It is associated with serious adverse health and behavioral effects and even death. Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities, four cases of driving under...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110410
更新日期：2020-09-01 00:00:00
abstract：:Petechial haemorrhages of the conjunctivae are not specific for lethal throttling or strangulation, but they belong to the important indicators for such mechanisms. In experimental models it is shown that petechial bleedings of the conjunctivae disappear with the occurrence of advanced signs of putrefaction or in case...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90243-7
更新日期：1994-01-01 00:00:00
abstract：:Fibronectin plays an important role in tissue repair and wound healing. Previous literature reports indicated that fibronectin could be a marker of vitality for wounds with a survival time of more than a few minutes. In order to verify these findings were performed immunohistochemical investigations on the expression ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(98)00147-9
更新日期：1998-11-09 00:00:00
abstract：BACKGROUND:The study of post mortem vitreous magnesium (Mg) is less common than sodium (Na), chloride (Cl) and potassium (K) in the forensic literature. There is no accepted normal range for post mortem vitreous Mg and the relationship between post mortem vitreous Mg levels and post mortem interval (PMI), other electro...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.12.038
更新日期：2018-03-01 00:00:00
abstract：:Forensic identification of sudden unexplained death (SUD) has always been a ticklish issue because it used to be defined as sudden death without a conclusive diagnosis after autopsy. However, benefiting from the developments in genome research, a growing body of evidence points to the importance of ion channelopathies...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2017.03.006
更新日期：2017-06-01 00:00:00
abstract：:In this study, we resolved the allelic distribution of three Y chromosomal short tandem repeats (STRs), DYS19 (n=218), DYS390 (n=257) and DYS393 (n=215), in a population study of 257 unrelated men living in the area of South Wüerttemberg/Hohenzollern. In DYS19 and in DYS393, five different alleles were discovered, and...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00195-x
更新日期：2000-09-11 00:00:00
abstract：:The aim of any forensic inquiry concerning accidental or criminal cremations is to identify the victims. This identification depends on an essential approach: a careful collection and ultrasonic cleaning of the fragments and splinters of burned bones, and reconstruction--as far as possible--of bone specimens, which im...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/s0379-0738(98)00115-7
更新日期：1998-09-28 00:00:00
abstract：:This method for the determination of haloperidol (HAL) in plasma is based on high-performance liquid chromatography (HPLC) with a reversed-phase column, ODS-C18. HAL is rapidly extracted from human plasma by using Bond Elut C18 cartridge and its recovery is over 90%. The mobile phase is a mixture of 1% acetate/acetoni...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(87)90025-9
更新日期：1987-09-01 00:00:00
abstract：:An interrelation between consumption of illegal drugs and committing an indictable offence has been repeatedly discussed in literature. In a retrospective study serum concentrations of illegal and legal drugs as well as data originating from police reports and examinations by physicians taking blood from individuals b...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.01.031
更新日期：2013-03-10 00:00:00
abstract：OBJECTIVE:To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning. METHOD:After establishing and validating BuChE activity test, and making it available for clinical service in the toxico...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.074
更新日期：2006-10-16 00:00:00
abstract：:A new series of fingerprint developing membrane were prepared using ninhydrin as the developing agent, and pressure-sensitive emulsifiers as the encapsulated chemicals. The type of emulsifier, plastic film, concentration of the developing agent, modifying ions and thickness of the membrane were studied in order to get...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.06.036
更新日期：2014-09-01 00:00:00
abstract：:This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to pipe...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.10.006
更新日期：2012-11-30 00:00:00
abstract：:Bloodstain pattern analysis (BPA) of bloodstains on hard, non-porous surfaces has found widespread use in crime scene analysis and reconstruction for violent crimes in which bloodshed occurs. At many violent crime scenes, bloody clothing is also found and may be analyzed. However, to date, there are no definitive meth...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.04.011
更新日期：2017-07-01 00:00:00
abstract：:Allele frequencies for the 15 STR locus of PowerPlex 16 were analyzed in 95 healthy unrelated individuals belonging to five important population groups inhabiting different part of India. Fifteen loci studied are Penta E, D18S51, D21S11, THO1,D3S1358, FGA, TPOX, D8S1179, vWA, Amelogenin, Penta D, CSF1PO, D16S539, D7S8...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00021-x
更新日期：2002-04-18 00:00:00
abstract：:Raman spectroscopy has been used for the development of a universal method for the identification of traces of all major body fluids. Multidimensional spectroscopic signatures, which account for the intrinsic sample heterogeneity and variations between donors, have been described for blood, semen, saliva, vaginal flui...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.04.021
更新日期：2014-07-01 00:00:00
abstract：:Allele frequencies have been calculated in 13 STR loci in a Roma (Gypsy) population sample from Greece. The data can be used in forensic cases. The comparison of the allele frequencies between the Roma and the Greeks showed significant differences for the majority of the loci. Furthermore comparison to another Romany ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.03.021
更新日期：2006-03-10 00:00:00
abstract：:During a one-year-period 1243 medicolegal deaths in the City of Copenhagen were autopsied after the mode of death was provisionally determined by an external medicolegal examination. In 35% of the cases an atuopsy was requested by the police. Without autopsy the mode of death would have been defined erroneously in 10....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(79)90137-3
更新日期：1979-11-01 00:00:00
abstract：:A comparison study of the American style ASP extendible police baton with the conventional UK police wooden truncheon was performed. It was found that the ASP baton generated approximately twice the contact pressure than the conventional wooden truncheon. A discussion on the medical/legal aspects of the results are gi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90411-1
更新日期：1994-06-28 00:00:00
