Abstract：
:Alcohol exposure can reduce adult proliferation and/or neurogenesis, but its impact on the ultimate neurogenic precursors, neural stem cells (NSCs), has been poorly addressed. Accordingly, the impact of voluntary consumption of alcohol on NSCs in the subventricular zone (SVZ) of the lateral ventricle was examined in this study. The NSC population in adult male C57BL/6J mice was measured after voluntary alcohol exposure in a two-bottle choice task using the neurosphere assay, while the number of NSCs that had proliferated 2 weeks prior to tissue collection was indexed using bromodeoxyuridine (BrdU) retention. There was a significant decrease in the number of BrdU-retaining cells in alcohol-consuming mice compared with controls, but no difference in the number of neurosphere-forming cells that could be derived from the SVZ of alcohol-consuming mice compared with controls. Additionally, PCNA-labeled cells in the SVZ tended to be lower, but there was no difference in BrdU labeling in the dentate gyrus following alcohol exposure. To determine alcohol's direct impact on NSCs and their progeny, neurospheres derived from naïve mice were treated with alcohol in vitro. Neurosphere formation was reduced by 100 mM alcohol without reducing cell viability. These findings are the first to assess the impact of moderate voluntary alcohol consumption on selective measures of adult NSCs and indicate that such exposure alters NSC proliferation dynamics in vivo and alcohol has direct but dissociable effects on the expansion and viability on NSCs and their progeny in vitro.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Campbell JC,Stipcevic T,Flores RE,Perry C,Kippin TEdoi
10.1007/s00221-014-3958-1subject
Has Abstractpub_date
2014-09-01 00:00:00pages
2775-84issue
9eissn
0014-4819issn
1432-1106journal_volume
232pub_type
杂志文章abstract：:The excitability of the corticospinal motor pathways to transcranial magnetic stimulation (TMS) can be differentially modulated by a variety of motor tasks. However, there is emerging evidence that linguistic tasks may alter excitability of the corticospinal motor pathways also. In this study we evaluated the effect o...
journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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doi：10.1007/s00221-008-1643-y
更新日期：2009-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00247312
更新日期：1988-01-01 00:00:00
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doi：10.1007/BF00231857
更新日期：1991-01-01 00:00:00
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doi：10.1007/BF00228525
更新日期：1991-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF02450322
更新日期：1997-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00221-010-2515-9
更新日期：2011-09-01 00:00:00
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doi：10.1007/s00221-013-3627-9
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pub_type： 杂志文章
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journal_title：Experimental brain research
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doi：
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