Abstract:
BACKGROUND:Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for wound healing and regeneration. Platelet-rich plasma (PRP) may improve the environment for BMSC development and differentiation. However, whether combined use of BMSCs and PRP may be more effective for accelerating diabetic ulcer healing remains unclear. OBJECTIVE:We investigated the efficacy of BMSCs and PRP for the repair of refractory wound healing in a diabetic rat model. METHODS:Forty-eight rats with diabetes mellitus induced by streptozotocin were divided into four groups: treatment with BMSCs plus PRP, BMSCs alone, PRP alone, phosphate buffered saline. The rate of wound closure was quantified. A histopathological study was conducted regarding wound depth and the skin edge at 7, 14, and 28 days after surgery. RESULTS:Wound healing rates were significantly higher in the BMSC plus PRP group than in the other groups. The immunohistochemistry results showed that the expression of platelet/endothelial cell adhesion molecule 1, proliferating cell nuclear antigen, and transforming growth factor-β1 increased significantly in the BMSC plus PRP group compared to the other treatment groups. On day 7, CD68 expression increased significantly in the wounds of the BMSC plus PRP group, but decreased markedly at day 14 compared to the controls. CONCLUSION:The combination of BMSCs and PRP aids diabetic wound repair and regeneration.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Lian Z,Yin X,Li H,Jia L,He X,Yan Y,Liu N,Wan K,Li X,Lin Sdoi
10.5021/ad.2014.26.1.1subject
Has Abstractpub_date
2014-02-01 00:00:00pages
1-10issue
1eissn
1013-9087issn
2005-3894journal_volume
26pub_type
杂志文章abstract::Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abd...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.2.219
更新日期:2010-05-01 00:00:00
abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S131
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.2.143
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the init...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.2.128
更新日期:2015-04-01 00:00:00
abstract::[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...
journal_title:Annals of dermatology
pub_type: 已发布勘误
doi:10.5021/ad.2018.30.4.511
更新日期:2018-08-01 00:00:00
abstract::Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fa...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.1.81
更新日期:2011-02-01 00:00:00
abstract::A 70-year-old woman with an 8-year history of systemic sarcoidosis developed round, red-brown eruptions, with central atrophic lesions on her lower legs. The features of the biopsy specimen resembled those of necrobiosis lipoidica (NL), but although necrobiosis was present there were well-formed non-necrotizing granul...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2012.24.1.74
更新日期:2012-02-01 00:00:00
abstract::Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who p...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.1.48
更新日期:2010-02-01 00:00:00
abstract::We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.1.98
更新日期:2009-02-01 00:00:00
abstract::Matridex(R) is an injectable skin filler that's composed of a mixture of cross linked hyaluronic acid and dextranomer particles, and it was recently developed for soft tissue augmentation. To the best of our knowledge, there have been few previous reports on complications associated with Matridex. We report here on a ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.1.81
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.2.189
更新日期:2013-05-01 00:00:00
abstract::Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious f...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.3.327
更新日期:2017-06-01 00:00:00
abstract::Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walki...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S239
更新日期:2011-10-01 00:00:00
abstract::Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenita...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.3.381
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2011.23.1.33
更新日期:2011-02-01 00:00:00
abstract::Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by several erythematous papules on the lower b...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.233
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Gray hair naturally develops in the process of human aging. Many people with gray hair periodically dye their hair. Hair dyeing products are widely used and they can cause adverse effects. Therefore, the user's knowledge and recognition about hair dyeing and related side effects are important. OBJECTIVE:The...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.3.274
更新日期:2012-08-01 00:00:00
abstract::Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few case...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.358
更新日期:2010-08-01 00:00:00
abstract::Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.1.119
更新日期:2010-02-01 00:00:00
abstract::A 28-year-old woman presented with multiple, asymptomatic, erythematous to bluish papules located on the chest. Histopathologically, three round, well defined cystic structures were seen on the upper and lower dermis. The first cyst was milia, the second was apocrine hidrocystoma and the other, largest cyst was an eru...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.1.11
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.2.189
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Recently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma. OBJECTIVE:To observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser. METHODS:...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2016.28.6.711
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is an autoimmune skin disease difficult to manage and treat. The pathogenesis of AA features a T-cell-associated autoimmune process, and systemic immunosuppressive therapy is prescribed widely for AA. OBJECTIVE:To evaluate the efficacy and tolerance of systemic low-dose methotrexate (LD...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.3.263
更新日期:2017-06-01 00:00:00
abstract:Background:Alopecia areata (AA) affects anagen hair follicles resulting in non-scarring hair loss. Since its introduction, superficial cryotherapy has been used as one of the meaningful treatment modalities for AA. Objective:The purpose of this study is to clarify the therapeutic efficacy and safety of superficial cry...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.6.722
更新日期:2017-12-01 00:00:00
abstract::Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2012.24.3.345
更新日期:2012-08-01 00:00:00
abstract::Bowen's disease usually manifests as a slowly enlarging erythematous scaly patch or plaque. An uncommon variant of Bowen's disease showing a verrucous appearance has been reported and a distinct variant with a prominent clear cell change on histopathology, in addition to a verrucous surface change, was also reported. ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.4.487
更新日期:2017-08-01 00:00:00
abstract::Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). Recently, hemidesmosomal EB has been propo...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S1.S41
更新日期:2011-09-01 00:00:00
abstract::Intravascular lymphoma (IVL) is a rare disorder characterized by the presence of large neoplastic lymphoid cells restricted to the lumens of small vessels with a predilection for the skin and the central nervous system. While the vast majority of cases involving IVL are of B-cell lineage, the disease rarely affects th...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.4.496
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.1.23
更新日期:2013-02-01 00:00:00
abstract::Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix a...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.6.751
更新日期:2014-12-01 00:00:00