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Extrapituitary growth hormone in the chicken reproductive system.

Abstract：

:Increasing evidence shows that growth hormone (GH) expression is not limited to the pituitary, as it can be produced in many other tissues. It is known that growth hormone (GH) plays a role in the control of reproductive tract development. Acting as an endocrine, paracrine and/or autocrine regulator, GH influences proliferation, differentiation and function of reproductive tissues. In this review we substantiate the local expression of GH mRNA and GH protein, as well as the GH receptor (GHR) in both male and female reproductive tract, mainly in the chicken. Locally expressed GH was found to be heterogeneous, with a 17 kDa variant being predominant. GH secretagogues, such as GHRH and TRH co-localize with GH expression in the chicken testis and induce GH release. In the ovarian follicular granulosa cells, GH and GHR are co-expressed and stimulate progesterone production, which was neutralized by a specific GH antibody. Both testicular and follicular cells in primary cultures were able to synthesize and release GH to the culture medium. We also characterized GH and GH mRNA expression in the hen's oviduct and showed that it had 99.6% sequence identity with pituitary GH. Data suggest local reproductive GH may have important autocrine/paracrine effects.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Luna M,Martínez-Moreno CG,Ahumada-Solórzano MS,Harvey S,Carranza M,Arámburo C

doi

10.1016/j.ygcen.2014.02.021

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

60-8

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(14)00076-8

journal_volume

203

pub_type

杂志文章,评审

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