当前位置： SCI文献检索 > PEDIATRIC RADIOLOGY期刊下所有文献 > Objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.

Objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.

Abstract：

BACKGROUND:Various skeletal muscle diseases result in fatty infiltration, making it important to develop noninvasive biomarkers to objectively measure muscular fat. OBJECTIVE:We compared T2 relaxation time mapping (T2 maps) and magnetic resonance spectroscopy (MRS) with physical characteristics previously correlated with intramuscular fat to validate T2 maps and MRS as objective measures of skeletal muscle fat. MATERIALS AND METHODS:We evaluated gluteus maximus muscles in 30 healthy boys (ages 5-19 years) at 3 T with T1-weighted images, T2-W images with fat saturation, T2 maps with and without fat saturation, and MR spectroscopy. We calculated body surface area (BSA), body mass index (BMI) and BMI percentile (BMI %). We performed fat and inflammation grading on T1-W imaging and fat-saturated T2-W imaging, respectively. Mean T2 values from T2 maps with fat saturation were subtracted from T2 maps without fat saturation to determine T2 fat values. We obtained lipid-to-water ratios by MR spectroscopy. Pearson correlation was used to assess relationships between BSA, BMI, BMI %, T2 fat values, and lipid-to-water ratios for each boy. RESULTS:Twenty-four boys completed all exams; 21 showed minimal and 3 showed no fatty infiltration. None showed muscle inflammation. There was correlation between BSA, BMI, and BMI %, and T2 fat values (P < 0.05), and between BMI and BMI %, and lipid-to-water ratios (P < 0.05). There was strong correlation between T2 fat values and lipid-to-water ratios (P < 0.0001, r = 0.83). CONCLUSION:T2 maps and MR spectroscopy correlate with physical characteristics associated with fatty infiltration of skeletal muscles, even in microscopic amounts, and validate each other. Both techniques might enable detection of minimal pathological fatty infiltration in children with skeletal muscle disorders.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Kim HK,Serai S,Merrow AC,Wang L,Horn PS,Laor T

doi

10.1007/s00247-013-2791-1

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

149-57

issue

eissn

0301-0449

issn

1432-1998

journal_volume

pub_type

杂志文章

在线工具

Objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.