Abstract:
BACKGROUND:Glucose variability has been identified as a predictor of hypoglycemia and has been associated with mortality in critically ill patients without diabetes. A popular metric to quantify glucose variability is the mean amplitude of glycemic excursions (MAGE). The "ruler and pencil" approach to calculate MAGE is operator-dependent and time-consuming for analysis of continuous glucose monitoring data. Therefore, several computer software programs have been developed for the automated calculation of MAGE. The aim of our study was to evaluate the agreement of currently available MAGE calculators when applied to the same set of continuous glucose monitoring (CGM) traces. MATERIALS AND METHODS:Four software programs for calculation of MAGE were identified and used to calculate MAGE of 21 CGM traces from seven patients with type 1 diabetes. Subsequently, the median MAGE per calculator was calculated. The correlation between the MAGE calculators was evaluated by Spearman's correlation analysis. Between-group comparison was performed using analysis of variance. RESULTS:The median MAGE (interquartile range) per calculator was 8.7 (7.1-10.7), 6.7 (5.5-8.6), 6.7 (5.2-8.6), and 5.8 (4.3-7.1), which was statistically different overall (P<0.001). The correlation coefficients between the calculators ranged from 0.787 to 0.999. CONCLUSIONS:Available computer programs developed to calculate MAGE show varying agreement. Although software programs for the calculation of MAGE would seem attractive to assess glucose variability, their use has limitations by different outcomes, in the absence of a gold standard.
journal_name
Diabetes Technol Therjournal_title
Diabetes technology & therapeuticsauthors
Sechterberger MK,Luijf YM,Devries JHdoi
10.1089/dia.2013.0138subject
Has Abstractpub_date
2014-02-01 00:00:00pages
72-5issue
2eissn
1520-9156issn
1557-8593journal_volume
16pub_type
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
doi:10.1089/152091501300209606
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
doi:10.1089/152091502760098456
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/152091502320798321
更新日期:2002-01-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
doi:10.1089/152091503322250578
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2018.0140
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,meta分析
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2016.0101
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/152091502760306544
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journal_title:Diabetes technology & therapeutics
pub_type: 临床试验,杂志文章
doi:10.1089/dia.2006.0059
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
doi:10.1089/dia.2009.0002
更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/dia.2014.0047
更新日期:2014-11-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2011.0004
更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1089/dia.2016.0311
更新日期:2016-12-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,多中心研究
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Diabetes technology & therapeutics
pub_type: 临床试验,杂志文章
doi:10.1089/dia.2005.7.124
更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2005.7.487
更新日期:2005-06-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2010.0188
更新日期:2011-05-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章,多中心研究
doi:10.1089/dia.2013.0074
更新日期:2013-11-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/152091503322250677
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journal_title:Diabetes technology & therapeutics
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2007-06-01 00:00:00
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journal_title:Diabetes technology & therapeutics
pub_type: 杂志文章
doi:10.1089/dia.2008.0041
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