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Synthesis and antibacterial properties of methylsulfinyl and methylsulfonyl analongs of some nitrofurans.

Abstract：

:The sulfoxides 5-methylsulfinyl-2-furaldehyde semicarbazone (2) and 1-[(5-methylsulfinyl-2-fufurylidene)amino]hydantoin (3) as well as the sulfones 1-[(5-methylsulfonyl-2-furfurylidene)animo]hydantoin (1) and 1-(5-methylsulfonly-2-furyl)-2-(6-amino-3-p-ridazyl)ethylene hydrochloride (4) have been prepared and tested for antibacterial activity against a number of gram-negative and gram-positive organisms. The compounds are much less active than the corresponding 5-nitrofuran derivatives, possibly because their reduction potentials are too negative for them to interfere with reductive enzyme systems within the bacteria.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Ekström B,Ovesson M,Pring BG

doi

10.1021/jm00245a030

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

1166-8

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

18

pub_type

杂志文章

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