L-arginine and nitric oxide in CNS function and neurodegenerative diseases.

Abstract:

:One of the main functions of L-arginine (ARG) is the synthesis of nitric oxide (NO). NO is an important regulator of physiological processes in the central nervous system (CNS). NO promotes optimal cerebral blood flow, consolidates memory processes, facilitates long-term potentiation, maintains sleep-wake cycles, and assists in normal olfaction. However, at pathological levels, NO adversely affects brain function producing nitroxidative stress and promoting development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and other disorders of the CNS. This review summarizes current knowledge of the role of NO in the CNS and the role of diet in regulating the levels of NO.

journal_name

Crit Rev Food Sci Nutr

authors

Virarkar M,Alappat L,Bradford PG,Awad AB

doi

10.1080/10408398.2011.573885

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1157-67

issue

11

eissn

1040-8398

issn

1549-7852

journal_volume

53

pub_type

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