Dietary fat and breast cancer mortality: A systematic review and meta-analysis.

Abstract:

BACKGROUND:The influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk. OBJECTIVE:To conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality. DESIGN:MEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast-cancer-specific death was evaluated by combining multivariable adjusted estimates comparing highest versus lowest categories of intake; and per 20 g increase in intake of total and/or saturated fat (g/day) using random-effects meta-analyses. RESULTS:Fifteen prospective cohort studies investigating total fat and/or saturated fat intake (g/day) and breast cancer mortality were included. There was no difference in risk of breast-cancer-specific death (n = 6; HR = 1.14; 95% CI: 0.86, 1.52; p = 0.34) or all-cause death (n = 4; HR = 1.73; 95% CI: 0.82, 3.66; p = 0.15) for women in the highest versus lowest category of total fat intake. Breast-cancer-specific death (n = 4; HR = 1.51; 95% CI: 1.09, 2.09; p < 0.01) was higher for women in the highest versus lowest category of saturated fat intake. CONCLUSIONS:These meta-analyses have shown that saturated fat intake negatively impacts upon breast cancer survival.

journal_name

Crit Rev Food Sci Nutr

authors

Brennan SF,Woodside JV,Lunny PM,Cardwell CR,Cantwell MM

doi

10.1080/10408398.2012.724481

subject

Has Abstract

pub_date

2017-07-03 00:00:00

pages

1999-2008

issue

10

eissn

1040-8398

issn

1549-7852

journal_volume

57

pub_type

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